“…For example, reduced input from neighbouring cells can result in neuronal cell loss, a phenomenon known as trans-synaptic degeneration (TSD) [160], which can occur following white matter dysfunction or insult and evolves slowly over many years [161]. In TSD, cells may atrophy, or undergo apoptosis in response to the decreased or absent afferent input [162],[163], or show reductions in synaptic density [164]. Although this has been best studied in lesion models, it is possible that an early static or neurodevelopmental process affectingwhite matter could result in slow changes to neuronal population number, size or dendritic arborization which could account for grey matter volumetric changes, such as those seen in schizophrenia [165].…”