Long term survival in small cell lung cancer: Posttreatment characteristics in patients surviving five to 18 + years

Normal serum neuron specific enolase (NSE) value after the first cycle of chemotherapy

“…predict response to therapy and survival, both to improve the selection of patients included in clinical tri-A complete response was defined as a complete disappearance of all known disease and was histologials and to elaborate new therapeutic strategies. [1][2][3][4][5][6][7][8][9][10][11] Data concerning biologic prognostic factors, however, cally confirmed by fiberoptic bronchoscopy. Evaluation was performed at the end of treatment.…”

“…triggered a controversy when they were assessed in multivariate analysis. [1][2][3][6][7][8][9] Only two parameters have been validated as independent prognostic factors by…”

Complete spontaneous remission in a patient with metastatic non-small-cell lung cancer

“…SR is, however, an exciting event, though the same applies to long term tumour dormancy [57,58] and exceptional treatment related cancer survival -even in extensive disease of small cell lung cancer, l%-2% of the patients survive more than 10 years [59]. Thus, in addition to rigid scrutiny of the rare carefully documented cases of spontaneous remissions, evaluation of the more frequent patients with an exceptionally favorable outcome following conventional oncological therapy and best case analysis of putative cancer regressions by unconventional treatment may help to elucidate the biological mechanisms involved in spontaneous remissions.…”