Long‐term survival in Japanese patients with far advanced carcinoma of the stomach

Abstract

Among 1,220 Japanese patients with gastric carcinoma who had undergone resection in the Department of Surgery II, Kyushu University Hospital, Fukuoka, Japan from 1965 to 1980, there were 432 (35.4%) with far advanced carcinoma, designated as a lesion with factors such as peritoneal dissemination, hepatic metastasis, widespread nodal involvement extending to tertiary (hepatoduodenal, retropancreatic, and mesenteric) or quaternary (middle colic and paraaortic) nodes, or direct invasion to adjacent organs. The overall 5‐year survival rate in these 432 patients was 10.2%. The 5‐year survival rate in patients with a single factor was 16.3%, being significantly higher than the 2.8% or less in cases with more than 2 factors (p<0.01). Patients with tertiary nodal involvement or directly invaded organs alone survived at a rate of 26.1% and 21.8% in the 5‐year follow‐up, respectively. Radical procedures such as extensive lymphadenectomy and combined resection of the invaded organs further lengthened the survival time. The 5‐year survival rates were less than 10% in patients with other factors, singly or more than 2 factors in combination. There appear to be 2 subgroups in whom the rates of survival differ: potentially curable and noncurable patients. More intensive therapeutic regimens corresponding to both groups need to be considered.

Phase II trial of combined treatment consisting of preoperative S-1 plus cisplatin followed by gastrectomy and postoperative S-1 for stage IV gastric cancer

“…In line with these reports, the R0 resection group in the present study exhibited a significantly better prognosis. It is well known that the prognosis in patients with GC with multiple stage IV factors is miserable [23][24][25]. By virtue of staging laparoscopy, we frequently confirmed overt peritoneal carcinomatosis (pre-P1) or FPGCs (pre-Cy1).…”

Prognostic factors in patients with advanced gastric cancer with macroscopic invasion to adjacent organs treated with radical surgery

“…The prognosis of patients with gastric cancer with invasion to adjacent organs (T4) was reported to be poor [1]. However, some patients treated by radical surgery can survive for a long time after surgery [2].…”

Adjuvant chemotherapy for gastric cancer: a comprehensive review

“…A gradual increase in overall survival after curative surgery for advanced gastric cancer has recently been reported [1]. Even after curative surgery, however, especially in the advanced stages of gastric cancer, re- [9].…”