Long-Term Survival in Bone-Predominant Metastatic Urothelial Carcinoma

Ramos, Jorge; Cheng, Heather H.; Yu, Evan Y.

doi:10.1016/j.clgc.2014.07.005

Cited by 8 publications

(10 citation statements)

References 21 publications

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“…However, excisional surgery is usually recommended for single spinal metastatic lesion with no live metastasis, 3 , 5 , 25 – 27 as long-term survival was achieved in some bone-predominant metastatic UC patients. 28 , 29 …”

Section: Discussionmentioning

confidence: 99%

<p>Role of Multimodal Treatment in Urothelial Carcinoma Spinal Metastasis: 15 Patients’ Experiences in a Single Center</p>

Wang¹,

Gào²,

Zhang³

et al. 2020

CMAR

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Spinal metastasis from urothelial carcinoma (UC) is relatively uncommon. The aim of the present study is to explore the clinicopathological features, surgical treatments and outcomes of this rare disease. Patients and Methods: Fifteen patients with UC spinal metastasis who received surgery in our center between 2009 and 2018 were retrospectively investigated. Clinical data, treatment options, and outcomes were analyzed. Results: For the 15 patients (9 men and 6 women), the primary tumors were located in the upper urothelial tract in ten and lower urothelial tract in five. UC mainly metastasized to the lumbar spine in seven cases, followed by the thoracic spine in five. Pathologic fracture and soft tissue mass with dura mater compression were observed in 66.7% and 93.3% cases, respectively. Palliative resection was performed in nine cases and excisional resection in six. Eleven patients received postoperative chemotherapy, including three with a preoperative ECOG score >2. Bisphosphonates were administered in all patients. Pain was relieved remarkably in all patients, and both the neurological function and general status were improved significantly after surgery. The median overall survival was 14 months. Log rank test showed that patients receiving postoperative chemotherapy survived longer than those without chemotherapy (p=0.037). WHO grade 3 was also correlated with poorer prognosis (p=0.012). Conclusion: Pathological fracture and soft tissue mass with dura mater compression is frequently observed on radiological images in patients with UC spinal metastasis. Surgery is useful to prevent deterioration of performance status and improve quality of life, which provide an opportunity for further systematic therapy. Multimodal treatments, including surgery, postoperative chemotherapy and bisphosphonates are recommended. WHO grade 2 and receiving postoperative chemotherapy were favorable prognostic factors for the overall survival of patients with UC spinal metastasis.

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Section: Discussionmentioning

confidence: 99%

<p>Role of Multimodal Treatment in Urothelial Carcinoma Spinal Metastasis: 15 Patients’ Experiences in a Single Center</p>

Wang¹,

Gào²,

Zhang³

et al. 2020

CMAR

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“…Bone metastasis is the relatively usual location due to urothelial carcinoma. According to Ramos et al, only 5-15% of patients with UC have solitary bone metastases and until today neither the prognosis nor the mechanism of development of bonepredominant metastatic from urothelial cancer have been clearly elucidated [10] . Taher et al (2006) suggest that bone site metastases depend on the degree of muscles invasions of the bladder neoplasm [7] .…”

Section: Discussionmentioning

confidence: 99%

“…Taher et al (2006) suggest that bone site metastases depend on the degree of muscles invasions of the bladder neoplasm [7] . Another study suggests that possible mechanism of bone metastases is the genetic changes of the tumor which is associated with either specific treatment sensitivity or less aggressive disease phenotype [10] . Nathoo et al (2011) postulate that the propensity of bladder cancer to spinal bone metastases is due to anatomical relationship between the urological venous system and the vertebral veins(Batson's plexus) [12] .…”

Section: Discussionmentioning

confidence: 99%

Unusual Tibial Site Metastases from a Muscle Invasive Urothelial Carcinoma: A Rare Case Report

Kastanis

Bachlitzanaki

Pantouvaki

et al. 2020

ijirms

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Bladder cancer is a common malignancy of genitourinary tract with a considerable morbidity and mortality. Muscle invasive urothelial carcinoma is the most common type of cancer especially in ages over 65 years old. Though various metastases have been observed, bone localization is the second site metastases and is appeared in pelvis and spine. We present a case with tibial diaphyseal bone metastases from urothelial carcinoma as a rare manifestation and we review the literature among diagnoses and therapeutic management.

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“…In the case report of Ramos et al [14] patient had a muscleinvasive disease with no lymphovascular invasion [14]. Radical cystectomy was performed after curative chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Disease or an Early Stage Bladder Cancer? A Difficult Question

Keskin¹

2017

JCPCR

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Bladder cancer is the second most common tumor in the urinary system. Compared to other malignancies, it has a relatively different metastatic potential. The skeletal system is the most common metastatic site of cancer. According to studies most common metastatic site of bladder cancer is skeletal system. In retrospective analysis; presence of bone metastasis was found to be more common in patients with deep muscle invasion than superficial muscular involvement and according to the histopathologic subgroup. Lymph node involvement, histologic grade, and pT stage were found to be prognostic factors for distant metastases. In contrast; there are cases with superficial tumors that develop metastasis in follow-up. Even if the patient was diagnosed at an early stage, we should be careful about bone metastasis that may develop in the follow-up.

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Long-Term Survival in Bone-Predominant Metastatic Urothelial Carcinoma

Cited by 8 publications

References 21 publications

<p>Role of Multimodal Treatment in Urothelial Carcinoma Spinal Metastasis: 15 Patients’ Experiences in a Single Center</p>

<p>Role of Multimodal Treatment in Urothelial Carcinoma Spinal Metastasis: 15 Patients’ Experiences in a Single Center</p>

Unusual Tibial Site Metastases from a Muscle Invasive Urothelial Carcinoma: A Rare Case Report

Metastatic Disease or an Early Stage Bladder Cancer? A Difficult Question

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