Long‑term survival in a recipient of kidney transplant without maintenance immunosuppression: A case report

Abstract

Abstract. Operational tolerance of an allograft kidney is the optimal condition in patients following kidney transplantation and recipient-mediated immunological rejection still remains the primary challenge following transplantation. In the present study, a case of long-term survival is reported in a patient following kidney transplantation without maintenance immunosuppression therapies for >10 years. Although the pathological conditions of the transplanted kidney revealed a degree of impaired kidney function, the patient exhibited a serum creatinine level of 119.2 µmol/l and no significant changes were observed in T or B cell biomarkers associated with immunologic tolerance. Notably, the patient's allograft was functioning normally. Consequently, further studies may need to elucidate the development of operational tolerance.

Fetal interventions for congenital renal anomalies

“…There continues to be progress made with graft matching and minimization of immunosuppression. While there have been cases of patients with long term survival and graft function following kidney transplants without immunosuppression (72), the risks of graft loss and dysfunction are thought to be very high with this approach. However, in order to broach the potential for organ transplantation without immunosuppression, the concept of induced immune tolerance has been increasingly studied (73).…”