Long-term survival following brain metastasis of Wilms tumor

Mohammad, Akbar M.; Meyer, John P.; Hakami, Nasrollah

doi:10.1016/s0022-3476(77)80398-3

Cited by 11 publications

(3 citation statements)

References 3 publications

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“…There are only 4 case reports in the literature of solitary brain metastases. They are usually associated with pulmonary metastases because of the pathway of tumor spread [1,[7][8][9]. In our patient, intensive combined modality treatments finally controlled metastatic disease outside the CNS.…”

Section: Discussionmentioning

confidence: 68%

“…However, the repeated chemotherapeutic regimens applied were unable to prevent a cerebral metastasis. Gross tumor resection and subsequent whole brain irradiation with total doses between 20 and 30 Gy followed by a boost to the primary tumor site between 10 and 15 Gy achieved cure in 4 patients and after successful treatment of pulmonary metastases in 3 patients at a followup between 2.5 and 9 years [1,[7][8][9]. Because of the few patients there are no data regarding the appropriate target volume in postoperative radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Postoperative limited volume irradiation in a child with a solitary brain metastasis from Wilms tumor: A case report

Kortmann

Budach

Niethammer

et al. 1997

Med. Pediatr. Oncol.

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An 11‐year‐old boy presented with a solitary cerebral metastasis 2.5 years after initial diagnosis and 4 months after successful combined modality treatment of a stage II recurrent Wilms tumor in the chest. Resection of the brain metastasis was followed by limited volume irradiation with 30.0 Gy total dose. After a follow‐up of 2.5 years the boy is in complete remission and shows no neurological or neuropsychological deficits indicating the possibility of curative postoperative radiotherapy of low toxicity and restricted to the tumor site in the presence of solitary brain metastases. Med. Pediatr. Oncol. © 1997 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Postoperative limited volume irradiation in a child with a solitary brain metastasis from Wilms tumor: A case report

Kortmann

Budach

Niethammer

et al. 1997

Med. Pediatr. Oncol.

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“…There have been occasional reports of children surviving cerebral metastases [16,17]. We recommend aggressive treatment (surgery, chemotherapy and radiotherapy) for paediatric intracranial parenchymal metastases from solid tumours, especially if the primary tumour and other metastases have apparently been under control.…”

Section: Clinical Diagnostic and Anatomical Findings In 7 Cases Of Tmentioning

confidence: 99%

Cerebral metastases in childhood malignancies

Taşdemiroğlu

Patchell

1997

Acta neurochir

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Between January 1982 to June 1994, 154 children with non-CNS malignant tumours excluding leukaemias and lymphomas were admitted and treated at the UKMC. Symptomatic (10 cases; 6.5%) and non-symptomatic (2 cases; 1.2%) cranial metastases (calvarial, dural and/or parenchymal) were seen in 12 (7.8%) cases. Among these 12 cases, 7 had intracranial parenchymal metastases (4.5%). Three cases had multiple intracranial parenchymal metastases. Only one case had infratentorial (cerebellar) metastasis. The patients' ages ranged from 1 to 18 years (mean age was 7.3 years). The male:female ratio was 5:2. While six patients' brain metastases diagnosed during subsequent relapses, one patient first presented with brain metastasis. Time elapsed between the diagnosis of the primary disease and intracranial metastasis ranged from 0 to 755 days (mean 327 days). Histopathological diagnoses were confirmed in 4 cases who had craniotomy and tumour removal. Mean survival following the diagnosis of intracranial lesion was 157 days (ranged from 0 to 412 days). Despite the aggressive treatment, including surgery, chemotherapy and radiotherapy, 6 cases died with progression or relapse of the intracranial disease. In conclusion, the incidence of paediatric intracranial parenchymal metastasis is 4.5%. Prognosis is poor and intracranial disease is the primary cause of death.

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