Long-term Survival and Mortality in Prostate Cancer Treated with Noncurative Intent

Abstract

Mortality in patients with stage M0 prostate cancer was surprisingly high when followup exceeded 10 years.

Conservative management of clinically localized prostate cancer

“…9 In this series, in the interval from 10±15 y 57%, from 15±20 y 71%, and from 20 y and onwards 71% of those that died, died of prostate cancer. 9 Based on this the authors later argue that all patients needs immediate aggressive local therapy.…”

“…9 In this series, in the interval from 10±15 y 57%, from 15±20 y 71%, and from 20 y and onwards 71% of those that died, died of prostate cancer. 9 Based on this the authors later argue that all patients needs immediate aggressive local therapy. 34 In their study Aus et al 9 de®ned the study population as those who died with the diagnosis of prostate cancer irrespective of the cause of death during 1988± 1990.…”

“…Recently, data have been presented suggesting that the longer a man lives with his prostate cancer the greater the risk that he dies of the tumor. 9 These data have challenged the concept of deferring treatment for men with longer life expectancy, but they appear not to be comparable with earlier data.…”

“…Moreover, a bias in the study design is that the follow-up time becomes directly related to when the patients were diagnosed. In fact Aus et al 9 found that a smaller proportion died from prostate cancer among those diagnosed in the 1980s than in the 1970s than in the 1960s. This corresponds to the increase in relative survival over time that has been described.…”

“…9 Based on this the authors later argue that all patients needs immediate aggressive local therapy. 34 In their study Aus et al 9 de®ned the study population as those who died with the diagnosis of prostate cancer irrespective of the cause of death during 1988± 1990. The de®ned follow-up time was from diagnosis to time of death.…”