Long term survival and abnormal liver fat accumulation in mice with specific thymidine kinase 2 deficiency in liver tissue
Qian Zhao,
Xiaoshan Zhou,
Jingyi Yan
et al.
Abstract:Deficiency in thymidine kinase 2 (TK2) causes mitochondrial DNA depletion. Liver mitochondria are severely affected in Tk2 complete knockout models and have been suggested to play a role in the pathogenesis of the Tk2 knockout phenotype, characterized by loss of hypodermal fat tissue, growth retardation and reduced life span. Here we report a liver specific Tk2 knockout (KO) model to further study mechanisms contributing to the phenotypic changes associated with Tk2 deficiency. Interestingly, the liver specifi… Show more
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