Long‐Term Survival After Resection of Periampullary Cancer

Ohtsuka, Masayuki; Miyazaki, Masaru

doi:10.1002/9781119188421.ch146

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2020

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“…However, the 5-year postresection survival rate of pancreatobiliary tumors is 20% [5]. It has been reported that after resection 39-67% of patients will have a recurrence with intrahepatic and local recurrence [6].…”

Section: Case Reportmentioning

confidence: 99%

Liquid biopsy and multi-analyte testing guided treatment of HER2 positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy

et al. 2020

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Section: Case Reportmentioning

confidence: 99%

Liquid biopsy and multi-analyte testing guided treatment of HER2 positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy

et al. 2020

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Factors influencing local and distant recurrence following resection of periampullary cancer

Bhandare

Mondal

Chaudhari

et al. 2021

British Journal of Surgery

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Background Recurrence of periampullary cancer after pancreatoduodenectomy is common. The aim of this study was to investigate patterns of recurrence, incidence, and factors associated with local and distant recurrences. Methods This retrospective, single-centre study included consecutive patients with periampullary cancer who underwent resection with curative intent from January 2012 to January 2018. Survival, patterns of recurrence, and factors associated with recurrences were analysed. Results Median overall survival (OS) and disease-free survival among 398 included patients was 58.4 and 49.5 months respectively. Twenty-three patients (5.8 per cent) developed isolated local recurrences (LR), 50 (12.6 per cent) developed LR along with distant metastasis (DM), and 103 (25.9 per cent) developed isolated DM. Median OS was 40.4 months for patients with isolated LR versus 23 months for those with DM (P < 0.001). Tumour subtype (distal common bile duct (CBD): odds ratio (OR) 6.18, 95 per cent c.i. 2.19 to 17.46) and node-positive status (OR 2.36, 1.26 to 4.43) were independently associated with higher rates of LR. The most common site for isolated LR was along the superior mesenteric artery (12 of 23 patients). Tumour subtype (distal CBD: OR 2.86, 1.09 to 7.52), nodal positivity (OR 2.46, 1.53 to 3.94), and presence of perineural invasion (OR 1.80, 1.02 to 3.18) were independently associated with DM. Conclusion Isolated LR is associated with better survival than DM and occurs most commonly along the superior mesenteric artery.

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Long‐Term Survival After Resection of Periampullary Cancer

Cited by 2 publications

References 38 publications

Liquid biopsy and multi-analyte testing guided treatment of HER2 positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy

Liquid biopsy and multi-analyte testing guided treatment of HER2 positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy

Factors influencing local and distant recurrence following resection of periampullary cancer

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