Long-Term Suppression of Testosterone After Treatment with a Gonadotropin-Releasing Hormone Agonist in a Woman with a Presumed Testosterone Secreting Ovarian Tumor

Leuprolide Acetate Therapy in Luteinizing Hormone–Dependent Cushing's Syndrome

“…A gonadotropin-releasing hormone analogue has proved effective in a patient with a testosterone-secreting ovarian tumor. 32 Despite complete suppression of endogenous luteinizing hormone secretion, cortisol insufficiency did not develop in our patient. Perhaps basal cortisol production was maintained by stimulation of the abnormal 5-HT 4 receptor by serotonin; this hypothesis could not be proved, however, because of the lack of availability of specific antagonists.…”

High concentrations of LH cause virilization in a postmenopausal woman

“…As her initial imaging was interpreted as showing no ovarian or adrenal tumor, ovarian hyperthecosis or an occult, small androgen‐secreting Leydig cell tumor that is not easily visualized was suspected . However, bilateral oophorectomy had no effect on her serum total testosterone concentration.…”

Hyperandrogenism in menopause: a case report and literature review

“…Of note, some ovarian [2, 11, 16, 17, 26, 29–31] and adrenal [18] testosterone-producing tumors are reported to be gonadotropin-responsive. This is supported by evidence that administering a GnRH agonist or antagonist in these cases can markedly decrease testosterone levels.…”

“…A second case report described a woman who was unwilling to undergo surgery because of the risk of worsening renal failure; she was treated with monthly depot injections of leuprolide for 15 months. Notably, after discontinuing leuprolide therapy she remained free of excess testosterone production for at least 4 years of follow-up [29]. A third case described a post-menopausal woman with elevated testosterone who was a poor surgical candidate.…”