Long-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet–induced obese rats

Baselga-Escudero, Laura; Pascual-Serrano, Aïda; Ribas‐Latre, Aleix; Casanova, Ester; Salvadó, M. Josepa; Arola, Lluís; Arola‐Arnal, Anna; Bladé, Cinta

doi:10.1016/j.nutres.2015.02.008

Cited by 65 publications

(53 citation statements)

References 40 publications

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“…There is evidence that GSPE may exert such effects on circulating HDL‐cholesterol levels by modulating the expression of hepatic microRNA (miR)‐33, an SREBP2 target which regulates cholesterol homeostasis in the liver via modulation of ABCA1 and ABCG1, and which has also been shown to regulate HDL‐cholesterol levels . Grape seed proacyanidin extract (25 mg/kg) administration in rats fed a high‐fat diet was associated with a repression in both Srebp2 and miR‐33a and elevated expression of Abca1, results that are supported in other studies by the same group . While plasma HDL‐cholesterol levels were slightly elevated in the presence of GSPE in these studies, these changes did not reach statistical significance, though reduced LDL levels were observed .…”

Section: Grape Seed Procyanidin Extractmentioning

confidence: 71%

Section: Grape Seed Procyanidin Extractmentioning

confidence: 99%

“…There is additional evidence that dietary composition may influence the TG‐lowering ability of GSPE, which is suggested by studies using a high‐fat, high‐sugar “cafeteria diet” as a way to induce dyslipidemia . While some studies showed reduced serum TG levels with GSPE treatment in such a model, many have not . The cafeteria diet used in such studies allows the animals the option to freely consume not only high‐fat, high‐sugar foods, such as bacon, cheese, biscuits with paté, muffins, and sweetened milk but also standard chow and even low‐fat, high‐fiber foods such as raw carrots .…”

Section: Grape Seed Procyanidin Extractmentioning

confidence: 99%

See 2 more Smart Citations

Mechanistic insight into nuclear receptor‐mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE)

Downing

Edgar

Ellison

et al. 2017

Cell Biochemistry & Function

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Dietary procyanidins have emerged as important bioactive components that regulate various metabolic pathways to maintain homeostasis. Grape seed procyanidin extract (GSPE), in particular, has demonstrated regulatory effects on bile acid and lipid metabolism in vivo. While numerous studies in rodent models have shown the potent hypolipidemic action of grape seed extracts, human studies have shown inconsistent results. This review will focus on the molecular mechanisms underlying the hypolipidemic actions of GSPE identified to date, specifically highlighting the effects exerted via nuclear receptors. Such evidence may provide avenues for future research in human subjects with GSPE as a therapeutic treatment for the prevention and amelioration of the metabolic syndrome and cardiovascular disease.

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Section: Grape Seed Procyanidin Extractmentioning

confidence: 71%

Section: Grape Seed Procyanidin Extractmentioning

confidence: 99%

Section: Grape Seed Procyanidin Extractmentioning

confidence: 99%

See 1 more Smart Citation

Mechanistic insight into nuclear receptor‐mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE)

Downing

Edgar

Ellison

et al. 2017

Cell Biochemistry & Function

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show abstract

“…Moreover, Baselga-Escudero et al reported normalized liver miR-33a and miR-122 levels in high-fat diet-induced obese rats treated with a low dose of proanthocyanidins [83]. These compounds are the most abundant flavonoids in the human diet, and their beneficial effect may rely on the microbial catabolism leading to the subsequent release of absorbable metabolites [84].…”

Section: Gut Microbiota and Mirs Modulation: From Association To Causmentioning

confidence: 99%

MicroRNAs: Decoders of Dysbiosis into Metabolic Diseases?

Sérino¹

2016

J Diabetes Metab

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The identification of molecular factors bridging gut microbiota dysbiosis to alterations of host metabolism still remains a major goal in biomedical research. In fact, on one hand, there is a worldwide consensus about the systemic impact, from brain to liver, from heart to adipose tissue, of gut microbiota dysbiosis. On the other hand, beyond the microbial production of short chain fatty acids and their vast metabolic properties, little is known about the molecular mechanisms linking a change in the activity of gut microbes to a modification of host cell metabolism. In this context, microRNAs (also known as miRs) are promising molecules which could allow explaining how dysbiosis is converted into metabolic outcomes since: 1-miRs are pleiotropic regulators of gene expression, targeting multiple mRNAs at once; 2-miRs expression in specific organs such as the intestine has been demonstrated to be under the control of gut microbiota; 3-alterations in miRs expression have been found in the majority of tissues targeted by gut microbiota dysbiosis during metabolic diseases such as liver, adipose tissue, pancreas, skeletal muscle, intestine, heart and also the brain. In this review publications in the growing field of miRsbased metabolic control at a systemic level will be discussed together with a putative link with gut microbiota dysbiosis.

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“…It has been reported in the literature that different types of polyphenols, such as proanthocyanidins or a mixture extracted from Hibiscus sabdariffa , are able to modify the expression of miRNA-122-5p (a liver specific miRNA and the most abundant one) and the paralogs miRNA-103-3p and miRNA-107-3p in liver [16,17,18,19]. …”

Section: Introductionmentioning

confidence: 99%

Are miRNA-103, miRNA-107 and miRNA-122 Involved in the Prevention of Liver Steatosis Induced by Resveratrol?

et al. 2017

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The aim of the present study was to determine whether the reduction in liver fat previously observed in our laboratory in a cohort of rats which had been fed an obesogenic diet was mediated by changes in the expression of microRNA (miRNA)-103-3p, miRNA-107-3p and miRNA-122-5p, which represent 70% of total miRNAs in the liver, as well as in their target genes. The expression of the three analysed miRNAs was reduced in rats treated with resveratrol. A reduction in sterol-regulatory element binding protein 1 (SREBP1) and an increase in carnitine palmitoyltransferase 1a (CPT1a) were observed in resveratrol-treated rats. No changes were found in fatty acid synthase (FAS). In cultured hepatocytes, SREBP1 protein was increased after the transfection of each miRNA. FAS protein expression was decreased after the transfection of miRNA-122-5p, and CPT1a protein was down-regulated by the over-expression of miRNA-107-3p. This study provides new evidences which show that srebf1 is a target gene for miRNA-103-3p and miRNA-107-3p, fasn a target gene for miRNA-122-5p and cpt1a a target gene for miRNA-107-3p. Moreover, the reduction in liver steatosis induced by resveratrol in rats fed an obesegenic diet is mediated, at least in part, by the increase in CPT1a protein expression and activity, via a decrease in miRNA-107-3p expression.

show abstract

Long-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet–induced obese rats

Cited by 65 publications

References 40 publications

Mechanistic insight into nuclear receptor‐mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE)

Mechanistic insight into nuclear receptor‐mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE)

MicroRNAs: Decoders of Dysbiosis into Metabolic Diseases?

Are miRNA-103, miRNA-107 and miRNA-122 Involved in the Prevention of Liver Steatosis Induced by Resveratrol?

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