Long-term supplementation of esculetin ameliorates hepatosteatosis and insulin resistance partly by activating AdipoR2–AMPK pathway in diet-induced obese mice

Tomato glycosyltransferase Twi1 plays a role in flavonoid glycosylation and defence against virus

“…Similarly to other GTs, Twi1 seemed fairly specific to the sugar donor while recognising various substrates in vitro [26,38,[42][43][44][45][46][47][48]. Accumulation of coumarins has been reported to occur in plants in response to wounding and infections with different pathogens [9,[49][50][51][52][53][54][55][56][57][58][59]. They also display antimicrobial and antioxidant activities [32, [60][61][62].…”

Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis

“…In addition, esculetin did not have any mutagenic or genotoxic effect in cultured human lymphocytes (Maistro et al, 2015). Esculetin also shows a potential therapeutic role in cancer (Cho et al, 2015), obesity (Kim and Lee, 2015;Sim et al, 2015), and diabetes (Surse et al, 2011). Recently, we have reported that Esculetin shows cardioprotective effect by reversing post translational histone modifications associated with IR and type 2 diabetes (Kadakol et al, 2015b).…”

“…Esculetin (6, 7-dihydroxycoumarin), a functional food ingredient found in medicinal plants [e.g. Artemesia capillaries, Citrus limonia, and Euphorbia lathyris] is used in various inflammatory, allergic and infectious diseases (Chang et al, 1996;Sim et al, 2015). It has been reported to have a potent anti-oxidant (Kadakol et al, 2015a), anti-inflammatory (Kim et al, 2014) and anti-proliferative (Kim and Lee, 2015) activity.…”

Esculetin reverses histone H2A/H2B ubiquitination, H3 dimethylation, acetylation and phosphorylation in preventing type 2 diabetic cardiomyopathy

“…In addition, esculetin was reported to have anti-adipogenic effect through modulation of PPARγ and C/EBPα via the AMPK signalling pathway in 3T3-L1 adipocytes (Kim & Lee, 2015). Recently, it has been found that in HFD-induced obese mice, esculetin supplementation prevented hepatosteatosis and insulin resistance partly via activation of the AdiopR2-AMPK pathway (Sim, Lee, Ham, Seo, & Lee, 2015). However, until now, the effect of esculetin on diabetic cardiomyopathy is unknown.…”