Long-Term Success in the Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee With Subtotal Synovectomy and Radiotherapy

Carvalho, Lucas Resende de; Soares, Luiz Fernando Machado; Gonçalves, Matheus Braga Jacques; Temponi, Eduardo Frois; Jr., Otávio de Melo Silva

doi:10.1016/j.arthro.2012.02.007

Cited by 42 publications

(43 citation statements)

References 17 publications

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“…20 A similar surgical approach to that of the current study was described by de Carvallo et al 21 The reported recurrence rates were 12.5% and 9%, respectively. The efficiency of the therapy was shown with significant MRI changes and 99m Tc-pertechnetate uptake that had a good correlation with the clinical outcome.…”

Section: Discussionsupporting

confidence: 67%

A Low Recurrence Rate is Possible With a Combination of Surgery and Radiosynovectomy for Diffuse Pigmented Villonodular Synovitis of the Knee

Koca¹,

Özsoy²,

Atilgan³

et al. 2013

Clinical Nuclear Medicine

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Section: Discussionsupporting

confidence: 67%

A Low Recurrence Rate is Possible With a Combination of Surgery and Radiosynovectomy for Diffuse Pigmented Villonodular Synovitis of the Knee

Koca¹,

Özsoy²,

Atilgan³

et al. 2013

Clinical Nuclear Medicine

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“…Patient are implemented an average of 2000cGy dose of 10 sessions of radiotherapy. 8 In a series of 22 patients of Blanco, recurrence was observed in 3 patients (13.6%). After arthroscopic synovectomy, in the form of external beam radiotherapy; a total dose of 2600 cGy radiotherapy was used.…”

Section: Resultsmentioning

confidence: 97%

Radiotherapy on knee–related pigmented villonodular synovitis

Batıbay¹,

Batibay²

2018

IJRRT

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“…Follow-up for a mean 8.6 years showed no arthritis progression, postoperative complications or RT late effect in seven patients. Two developed quadricipital muscle atrophy and one synovial effusion [28].…”

Section: Discussionmentioning

confidence: 99%

“…Several recent publications showed favorable effect of external beam RT as a postoperative treatment [11,12,18,[28][29][30][31]. The GCG-BD group conducted a pattern-of-care study to analyze the RT for PVNS [12].…”

Section: Discussionmentioning

confidence: 99%

Pigmented Villonodular Synovitis for Combined Therapy

Rozin

2014

J Med Cases

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Pigmented villonodular synovitis (PVNS), inflammatory proliferative disease resulting from synovial cells, has progressive course similar neoplastic local expansion. We followed up a case with effective combined therapy for diffuse PVNS despite incomplete response to its components and reviewed therapies based on MedLine for PVNS. Due to US data residue synovitis after open radical synovectomy, we made decision about external beam radiotherapy. Photon radiation with linear accelerator energy of 6 MV was applied for two fields: anterior and posterior. The total dose was 20 Gy, delivered in 2 Gy a day, five times a week. Due to postoperative pain and the rest of synovial tissue on US study, pharmacologic therapy with salazopyrine and celecoxib was added. For several weeks, the knee pain became episodic and further disappeared. Six months later, the patient feels healthy and continues to take salazopyrine permanently and celecoxib as needed. We conclude high rate response analyzing literature data and our case to combined therapy: arthroscopic or open surgery followed by RT along with complimentary pharmacotherapy.

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Long-Term Success in the Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee With Subtotal Synovectomy and Radiotherapy

Cited by 42 publications

References 17 publications

A Low Recurrence Rate is Possible With a Combination of Surgery and Radiosynovectomy for Diffuse Pigmented Villonodular Synovitis of the Knee

A Low Recurrence Rate is Possible With a Combination of Surgery and Radiosynovectomy for Diffuse Pigmented Villonodular Synovitis of the Knee

Radiotherapy on knee–related pigmented villonodular synovitis

Pigmented Villonodular Synovitis for Combined Therapy

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