Long-term stepwise sustained improvement in left ventricular ejection fraction after myocardial infarction

Silbergerg, Jonathan; Haichin, Richard; Stewart, Susan L.; Lisbona, Robert; Sniderman, Allan D.

doi:10.1016/0002-8703(89)90725-4

Cited by 10 publications

(2 citation statements)

References 24 publications

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“…The greater improvement in LV function observed in our study is due partly to this time difference because recovery in LV function after coronary revascularization is a progressive phenomenon. 27,28 In addition to the postoperative assessment of global LV function, repeat SPECT perfusion imaging, which was seldom addressed in previous studies, 4,5,18,25,26 was also evaluated by us. The scintigraphic evaluation revealed a significant improvement not only in the reversibility score, but also in the defect score in patients with severe LV dysfunction, whereas an improvement was found only in reversibility score in those without such dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Functional Recovery After Coronary Artery Bypass Grafting in Patients With Severe Left Ventricular Dysfunction and Preserved Myocardial Viability in the Left Anterior Descending Arterial Territory as Assessed by Thallium-201 Myocardial Perfusion Imaging

et al. 1999

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he prognosis of patients with coronary artery disease and severe left ventricular (LV) dysfunction is poor, unless significant functional recovery is gained with coronary revascularization to viable myocardium. [1][2][3][4][5][6][7][8] The purpose of the present study was to evaluate the clinical significance of myocardial viability in the territory supplied by the left anterior descending artery (LAD) in patients with severe LV dysfunction (ejection fraction (EF) ≤35%) who underwent coronary artery bypass grafting (CABG), because the prognostic and procedural significance of CABG to the LAD coronary artery was underscored recently. 9-11 Methods Study PatientsOne hundred consecutive patients, all who demonstrated of having myocardial viability in the LAD territory and who undergone CABG (66 men, 34 women, aged 42-85 years [mean, 66]) were studied retrospectively. Previous myocardial infarction and CABG had occurred in 66 and 3 patients, respectively. Left main coronary artery disease was found in 31 patients, 3-vessel disease in 44, 2-vessel disease in 23, and 1-vessel disease in 2. Written informed consent was obtained from all of the patients. EchocardiographyEchocardiographms were performed using a Toshiba SSH-65A (Tokyo, Japan) or an Aloka SSD-710 (Tokyo, Japan) with 2.5-3.75 MHz transducers. A complete Mmode and 2-dimensional study were performed and recorded on video tape for subsequent analysis. LV segmental wall motion abnormality and systolic wall thickJpn Circ J 1999; 63: 752 -758 (Received May 6, 1999; revised manuscript received June 24, 1999; accepted July 5, 1999 To evaluate the functional recovery after coronary bypass surgery in patients with severe left ventricular (LV) dysfunction (ejection fraction (EF) ≤35%), 100 consecutive patients with viable myocardium in the territory supplied by the left anterior descending artery (LAD) underwent coronary bypass grafting. In addition, cardiac catheterization and single-photon emission computed tomography (SPECT) perfusion imaging with thallium-201 were repeated 1-year postoperatively. Although 12 patients with severe LV dysfunction were preoperatively in a worse New York Heart Association functional class (3.1±0.7 vs 2.4±0.8; p<0.01), had a higher incidence of heart failure (10/12 vs 14/88; p<0.001) and had a worse LVEF (29±5 vs 61±14%; p<0.001) compared with 88 patients without severe LV dysfunction, the operative mortality was similar in the 2 groups (1/12 vs 2/88; p=NS). The postoperative NYHA functional class in the patients with severe LV dysfunction was similar to that in the patients without such dysfunction (1.6±0.7 vs 1.3±0.6; p=NS). In addition, the 1-year postoperative study revealed a significant improvement in the thallium defect score in both the LAD territory (1.7±1.2 to 0.7±1.0, p=0.01) and all the territories (5.2±2.2 to 3.2±1.9, p=0.002) in patients with severe LV dysfunction, whereas no improvement in defect score was found in either of these territories in those without severe LV dysfunction (LAD: 0.6±1.4 to 0.4±1.2, p=NS; All: 1.9±...

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Section: Discussionmentioning

confidence: 99%

Functional Recovery After Coronary Artery Bypass Grafting in Patients With Severe Left Ventricular Dysfunction and Preserved Myocardial Viability in the Left Anterior Descending Arterial Territory as Assessed by Thallium-201 Myocardial Perfusion Imaging

et al. 1999

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“…The perfusion in the distribution of dilated artery has been shown to improve progressively until 3 months [4]. Many authors have not found any difference in LV ejection fraction values in the third and sixth month following AMI [5][6][7]. This makes us hypothesize that majority of the improvement occurs in the first 3-4 months.…”

Section: Introductionmentioning

confidence: 95%

Evaluation of changes in perfusion defect and left ventricular systolic function using Tc-99m Tetrofosmin single photon emission computed tomography over 3 month period in patients of Acute Myocardial Infarction undergoing primary angioplasty

Kumar

Swami

et al. 2018

Nucl. Med. Rev.

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Late streptokinase infusion and antithrombotic treatment in myocardial infarction reduce subsequent myocardial ischemia

Grip

Rydén

1991

American Heart Journal

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Long-term stepwise sustained improvement in left ventricular ejection fraction after myocardial infarction

Cited by 10 publications

References 24 publications

Functional Recovery After Coronary Artery Bypass Grafting in Patients With Severe Left Ventricular Dysfunction and Preserved Myocardial Viability in the Left Anterior Descending Arterial Territory as Assessed by Thallium-201 Myocardial Perfusion Imaging

Functional Recovery After Coronary Artery Bypass Grafting in Patients With Severe Left Ventricular Dysfunction and Preserved Myocardial Viability in the Left Anterior Descending Arterial Territory as Assessed by Thallium-201 Myocardial Perfusion Imaging

Evaluation of changes in perfusion defect and left ventricular systolic function using Tc-99m Tetrofosmin single photon emission computed tomography over 3 month period in patients of Acute Myocardial Infarction undergoing primary angioplasty

Late streptokinase infusion and antithrombotic treatment in myocardial infarction reduce subsequent myocardial ischemia

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