Long-term stability of PDMS-based microfluidic systems used for biocatalytic reactions

Klammer, I; Hofmann, M.; Buchenauer, Andreas; Mokwa, W.; Schnakenberg, Uwe

doi:10.1088/0960-1317/16/11/025

Cited by 11 publications

(8 citation statements)

References 16 publications

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“…The extraction of these PDMS oligomers from the bulk polymer with solvents leads to have hydrophilic surfaces that slowly regenerate into hydrophobic surfaces [67]. Klammer et al [68] showed that PDMS requires a preconditioning in alkaline solution for 5-6 days before starting biocatalytic reactions. We believe that the conditioning of a PDMS surface with a saline solution could lead to similar surface modifications.…”

Section: Pdms "Conditioning" and Surface Propertiesmentioning

confidence: 99%

Colloidal surface interactions and membrane fouling: Investigations at pore scale

Bacchin

Marty

Duru

et al. 2011

Advances in Colloid and Interface Science

109

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Section: Pdms "Conditioning" and Surface Propertiesmentioning

confidence: 99%

Colloidal surface interactions and membrane fouling: Investigations at pore scale

Bacchin

Marty

Duru

et al. 2011

Advances in Colloid and Interface Science

109

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“…The potential difference across the insulating layer is V g − ψ 0 . The insulator is assumed to have a constant capacitance per unit area, C ins , that accurately describes the dielectric properties of common materials used in micro- and nanofluidic devices such as silicon dioxide (SiO 2 ), aluminum dioxide (Al 2 O 3 ), and poly(dimethylsiloxane) (PDMS). − The capacitive charge density induced at the surface of the insulator, σ ins , is given by Within the basic Stern model, the potential drops linearly across the solid−liquid interface by an amount ψ 0 − ψ DL . The relationship between this potential drop and the charge density screened by the double layer, σ DL , is given by where C Stern is the phenomenological Stern capacitance per unit area.…”

Section: Electrochemical Model Of Electrofluidic Gatingmentioning

confidence: 99%

Electrofluidic Gating of a Chemically Reactive Surface

Jiang

Stein

2010

Langmuir

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We consider the influence of an electric field applied normal to the electric double layer at a chemically reactive surface. Our goal is to elucidate how surface chemistry affects the potential for field-effect control over micro- and nanofluidic systems, which we call electrofluidic gating. The charging of a metal-oxide-electrolyte (MOE) capacitor is first modeled analytically. We apply the Poisson-Boltzmann description of the double layer and impose chemical equilibrium between the ionizable surface groups and the solution at the solid-liquid interface. The chemically reactive surface is predicted to behave as a buffer, regulating the charge in the double layer by either protonating or deprotonating in response to the applied field. We present the dependence of the charge density and the electrochemical potential of the double layer on the applied field, the density, and the dissociation constants of ionizable surface groups and the ionic strength and the pH of the electrolyte. We simulate the responses of SiO(2) and Al(2)O(3), two widely used oxide insulators with different surface chemistries. We also consider the limits to electrofluidic gating imposed by the nonlinear behavior of the double layer and the dielectric strength of oxide materials, which were measured for SiO(2) and Al(2)O(3) films in MOE configurations. Our results clarify the response of chemically reactive surfaces to applied fields, which is crucial to understanding electrofluidic effects in real devices.

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“…Poly(dimethylsiloxane), also known as PDMS, is a commonly used polymer based on its favourable properties including transparency, gas permeability and generally high level of stability [1] . The basic structure of the polymer is composed of –O–Si(CH 3 ) 2 – units which can be manufactured according to a variety of specific requirements depending upon the constraints of the application, i.e.…”

Section: Introductionmentioning

confidence: 99%

Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds

Waters

Finch

Bhuiyan

et al. 2017

Journal of Pharmaceutical Analysis

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This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability (Kp) values suggesting plasma-modified silicone membrane (PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.

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Long-term stability of PDMS-based microfluidic systems used for biocatalytic reactions

Cited by 11 publications

References 16 publications

Colloidal surface interactions and membrane fouling: Investigations at pore scale

Colloidal surface interactions and membrane fouling: Investigations at pore scale

Electrofluidic Gating of a Chemically Reactive Surface

Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds

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