Objective: To evaluate differences in long-term postretention changes between adolescents and adults. Materials and Methods: The sample included 96 subjects, 51 adolescents and 45 adults (14.2 6 0.8 and 21.5 6 6.8 years of age, respectively, at the end of treatment) retained for 3 years and followed approximately 16 years post treatment, who were randomly selected from two private practices. Prior to treatment, 38 and 58 had Class I and Class II malocclusions, respectively. Adolescents consistently showed greater increases of the occlusal variables than adults, with mandibular incisor irregularity and the PAR index attaining statistically significant (P , .05) levels. Arch length and mandibular intercanine width showed statistically significant decreases over time in both groups; maxillary intercanine and intermolar widths did not change significantly. Overjet increased significantly more in Class II patients than in Class I patients, whereas Class I patients showed significantly greater decreases in mandibular intermolar width than Class II patients. Conclusions: Over the 16-year posttreatment period, adolescents showed significantly greater increases in mandibular incisor irregularity, and the PAR index than adults. Treated Class I patients demonstrated less increase in overjet and greater decreases in mandibular intermolar width than Class II patients. (Angle Orthod. 2010;80:247-253.)