Long-Term Silicone Central Venous Catheters Impregnated With Minocycline and Rifampin Decrease Rates of Catheter-Related Bloodstream Infection in Cancer Patients: A Prospective Randomized Clinical Trial

Hanna, Hend; Benjamin, Robert S.; Chatzinikolaou, Ioannis; Alakech, Badie; Richardson, Deborah; Mansfield, Paul F.; Dvorak, Tanya; Munsell, Mark F.; Darouiche, Rabih O.; Kantarjian, Hagop; Raad, Issam

doi:10.1200/jco.2004.04.124

Cited by 177 publications

(107 citation statements)

References 28 publications

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“…A study of 356 non-tunneled catheters in cancer patients showed that impregnation of central venous catheters with minocycline and rifampicin was efficacious (3 vs 14 infections in impregnated vs nonimpregnated catheters) and safe in reducing catheter-related infections. 34 Catheter-related infections may be caused by fibrin deposition associated with these catheters and interventions to decrease fibrin deposition could reduce infections. In a recent study in 208 patients 33 the use of low-dose unfractionated heparin resulted in significant less catheter-related infections (6.8 vs 16.6%).…”

Section: Discussionmentioning

confidence: 99%

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

Nieboer

Vries

Mulder

et al. 2008

Bone Marrow Transplant

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Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia 410 days (P ¼ 0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P ¼ o0.01), and use of total parenteral nutrition (TPN, P ¼ 0.04) were predictive for catheter-related infections. In conclusion, a high incidence of catheter-related infections after high-dose chemotherapy was seen related to duration of neutropenia, use of the catheter for both stem-cell apheresis and high-dose chemotherapy, and use of TPN. Selective use and choice of catheters could lead to a substantial reduction of catheter-related infectious complications.

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Section: Discussionmentioning

confidence: 99%

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

Nieboer

Vries

Mulder

et al. 2008

Bone Marrow Transplant

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“…Authors were contacted for these nine studies; no more information was available for three, 11,54,60 no reply was received from four 53,61,65,72 and two authors said that they did not investigate either CRBSI or colonisation.…”

Section: Bias-funnel Plotsmentioning

confidence: 99%

“…For the 15 trials permitting more than one CVC per patient, randomisation was conducted by either randomising the CVCs to be inserted (n = 6) 11,38,57,58,64,70 or randomising patients who were due to have a CVC inserted (n = 9). Heparin CHSS CHSS, chlorhexidine and silver sulfadiazine molecularly bonded to the outer wall of the CVC body only.…”

Section: Quality Assessmentmentioning

confidence: 99%

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The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation

Hockenhull¹,

Dwan²,

Boland³

et al. 2008

Health Technol Assess

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment ProgrammeT he Health Technology Assessment (HTA) Programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA Programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA Programme is needs-led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in the NHS, the public and consumer groups and professional bodies such as royal colleges and NHS trusts. These sugges...

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“…In the guidelines published in 2011 was recommended the use of antimicrobial/antiseptic impregnated catheters (CHSS or rifampicin-minocycline impregnated catheters) if the CRBSI rate has not decreased after implementation of a strategy based in basic preventive measures (which include education, the use of a >0.5% chlorhexidine preparation with alcohol for skin antisepsis, and the use of maximal sterile barrier precautions) (1). This recommendation (with category IA) was based in 3 RCTs showed a reduction on the incidence of catheter tip colonisation with the use of second-generation CHSSimpregnated catheters (33)(34)(35) and two RCTs showing that rifampicin-minocycline impregnated catheters reduced the risk of CRBSI (36,37). We think that the use of antimicrobial/antiseptic impregnated catheters could reduce the incidence of CRBSI and catheter related costs.…”

mentioning

confidence: 99%

What is new for the prevention of catheter-related bloodstream infections?

Lorente

2016

Ann. Transl. Med.

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After the publication in 2011 of latest guidelines of the Centers for Disease Control and Prevention (CDC) for the prevention of catheter-related bloodstream infections (CRBSI) some interesting findings have been published in that field. There has been published that skin disinfection with chlorhexidine alcohol reduced the risk of CRBSI compared to skin disinfection with povidone iodine alcohol, that the implementation of quality improvement interventions reduced the incidence of CRBSI, that the use of chlorhexidine impregnated dressing compared to standard dressings reduced the risk of CRBSI and catheter related cost in an health economic model, and that the use of antimicrobial/antiseptic impregnated catheters reduced the incidence of CRBSI and catheter related cost in clinical studies.

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Long-Term Silicone Central Venous Catheters Impregnated With Minocycline and Rifampin Decrease Rates of Catheter-Related Bloodstream Infection in Cancer Patients: A Prospective Randomized Clinical Trial

Abstract: Long-term nontunneled central venous catheters impregnated with minocycline and rifampin are efficacious and safe in reducing catheter-related bloodstream infections in cancer patients.

Cited by 177 publications

References 28 publications

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation

What is new for the prevention of catheter-related bloodstream infections?

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