Long-term Sequelae after Recovery from Cytomegalovirus Pneumonia in Allogeneic Bone Marrow Transplant Recipients

Chien, Sin-Ming; Chan, Charles K.; Kasupski, George J.; Chamberlain, Dean; Fyles, Gillian; Messner, Hans A.

doi:10.1378/chest.101.4.1000

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…1,2 In the bone marrow transplant population, CMV infection has been correlated with the subsequent development of pulmonary abnormalities in long-term survivors. 3 CMV infection has also been shown to enhance the degree of graft versus host disease after bone marrow transplant. 4,5 This has been demonstrated clearly in animal models and has been shown as an association in humans.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility to Cytomegalovirus Infection May be Dependent on the Cytokine Response to the Virus

Geist

Hinde

2001

Journal of Investigative Medicine

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BackgroundCytomegalovirus (CMV) infection is an important cause of morbidity and mortality in an immunocompromised host. Pulmonary infection with CMV results in an inflammatory response, which includes the local production of cytokines. Cytokine production stimulated by CMV infection serves to activate a series of immunologic responses involved in viral clearance. Previous work has demonstrated that different mouse strains express variable sensitivity to CMV infection.MethodsUsing mouse strains that express sensitive (BALB/cj) and resistant (C57BL/6) CMV phenotypes, we asked whether the differences in susceptibility to infection were caused by differences in pulmonary cytokine production after intraperitoneal infection with CMV.ResultsC57 mice demonstrated a higher total bronchoalveolar lavage (BAL) and BAL lymphocyte count at 3 and 7 days after intraperitoneal infection compared with BALB mice. There were no differences in BAL cytokine production; however, we were able to demonstrate differences in CMV DNA load in the lungs of BALB mice compared with that of C57 mice. In addition, there appeared to be increased whole-lung production of the TH2 cytokine IL-10 in the BALB mice versus the C57 mice.ConclusionsThis observation suggests that the genetic susceptibility to CMV infection may, in part, be regulated by differences in cytokines production within the local environment.

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Section: Introductionmentioning

confidence: 99%

Susceptibility to Cytomegalovirus Infection May be Dependent on the Cytokine Response to the Virus

Geist

Hinde

2001

Journal of Investigative Medicine

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“…Although there have been several studies evaluating the risk of developing CMV pneumonia [7][8][9][10], there is very limited information on factors that determine outcome of CMV pneumonia [11]. There have been no randomized trials evaluating the treatment for CMV pneumonia.…”

mentioning

confidence: 99%

Reduced Mortality of Cytomegalovirus Pneumonia After Hematopoietic Cell Transplantation Due to Antiviral Therapy and Changes in Transplantation Practices

Erard

Guthrie

Seo³

et al. 2015

Clinical Infectious Diseases

123

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“…Chien et al describe seven BMT recipients, after CMV pneumonia. Five patients died, in the remaining two restrictive lung disease with lower DLCO was diagnosed [25]. Also, in kidney transplant recipients, CMV caused subclinical pulmonary dysfunction with pulmonary diffusion disturbances some months after active disease treatment [26].…”

Section: Discussionmentioning

confidence: 99%

Impairment of lung diffusion capacity—a new consequence in the long-term childhood leukaemia survivors

et al. 2019

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Childhood leukaemia survivors (CLS) are known to have developed long-term impairment of lung function. The reasons for that complication are only partially known. The aims of this study were to assess pulmonary function in CLS and identify (1) risk factors and (2) clinical manifestations for the impairment of airflow and lung diffusion. The study group included 74 CLS: 46 treated with chemotherapy alone (HSCT−), 28 with chemotherapy and haematopoietic stem cell transplantation (HSCT+), and 84 healthy subjects (control group (CG)). Spirometry and diffusion limit of carbon monoxide (DLCO) tests were performed in all subjects. Ten (14%) survivors had restrictive, five (7%) had obstructive pattern, and 47 (66%) had reduced DLCO. The age at diagnosis, type of transplant, and type of conditioning regimen did not significantly affect the pulmonary function tests. The DLCO%pv were lower in CLS than in CG ( p < 0.03) and in the HSCT+ than in the HSCT− survivors ( p < 0.05). The pulmonary infection increased the risk of diffusion impairment (OR 5.1, CI 1.16–22.9, p = 0.019). DLCO was reduced in survivors who experienced CMV lung infection ( p < 0.001). The main symptom of impaired lung diffusion was poor tolerance of exercise ( p < 0.005). The lower lung diffusion capacity is the most frequent abnormality in CLS. HSCT and pulmonary infection, in particular with CMV infection, are strong risk factors for impairment of lung diffusion capacity in CLS. Clinical manifestation of DLCO impairment is poor exercise tolerance. A screening for respiratory abnormalities in CLS seems to be of significant importance.

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Long-term Sequelae after Recovery from Cytomegalovirus Pneumonia in Allogeneic Bone Marrow Transplant Recipients

Cited by 7 publications

References 8 publications

Susceptibility to Cytomegalovirus Infection May be Dependent on the Cytokine Response to the Virus

Susceptibility to Cytomegalovirus Infection May be Dependent on the Cytokine Response to the Virus

Reduced Mortality of Cytomegalovirus Pneumonia After Hematopoietic Cell Transplantation Due to Antiviral Therapy and Changes in Transplantation Practices

Impairment of lung diffusion capacity—a new consequence in the long-term childhood leukaemia survivors

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