Long-term scarring outcomes and safety of patients treated with NovoSorbⓇ Biodegradable Temporizing Matrix (BTM): An observational cohort study

Lo, Clement; Wagstaff, Marcus J. D.; Barker, T. H. W.; Damkat-Thomas, Lindsay; Salerno, Sabrina; Holden, Devin N.; Concannon, Elizabeth; Heath, Kathryn; Coghlan, Patrick; Cleland, Heather

doi:10.1016/j.jpra.2023.05.003

Cited by 5 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wagstaff et al [9], Greenwood et al [20], and Lo et al [29] all demonstrated the favorable scarring characteristics and aesthetic outcomes of BTM postoperatively. However, they used a scar evaluation scale different from ours, and their populations of interest were mostly non-Asians.…”

Section: Discussionmentioning

confidence: 99%

Strategic Use of Biodegradable Temporizing Matrix (BTM) in Wound Healing: A Case Series in Asian Patients

Chen,

Lin,

Chang

et al. 2024

JFB

View full text Add to dashboard Cite

Skin and soft tissue reconstruction has long been based on the reconstructive ladder. However, a skin substitute has become popular due to its predictable outcomes, without donor-site morbidity. The biodegradable temporizing matrix (BTM; NovoSorb, PolyNovo Ltd., Port Melbourne, Australia) is a synthetic skin substitute that has recently gained its clinical application. Compared with those of other dermal templates, the clinical efficacy and performance of the BTM are not well established, especially among the Asian population. This study aims to share our experience and strategy of using BTM in various wound conditions. The data of patients who underwent skin and soft tissue reconstruction with BTM at a single institution between January 2022 and December 2023 were reviewed. The patient demographics, wound characteristics, surgical details, secondary procedures, and complications were recorded and analyzed. Postoperative 6-month photographs were collected and independently evaluated by two plastic surgeons and two wound care center nurses using the Manchester Scar Scale (MSS). This study included 37 patients, consisting of 22 males and 15 females with a mean age of 51.8 years (range, 18–86 years old). The wound etiologies included trauma (67.6%), necrotizing soft tissue infection (16.2%), burns (10.8%), toe gangrene (2.7%), and scar excision (2.7%). The average wound area covered by BTM was 50.6 ± 47.6 cm2. Among the patients, eight received concomitant flap surgery and BTM implantation, 20 (54.1%) underwent subsequent split-thickness skin grafts (STSG), and 17 had small wounds (mean: 21.6 cm2) healed by secondary intention. Infection was the most common complication, affecting six patients (n = 6 [16.2%]), five of whom were treated conservatively, and only one required debridement. Thirty-three patients (89.2%) had good BTM take, and only four had BTM failure, requiring further reconstruction. At the last follow-up, 35 out of the 37 patients (94.6%) achieved successful wound closure, and the total MSS score was 10.44 ± 2.94, indicating a satisfactory scar condition. The patients who underwent BTM grafting without STSG had better scar scores than those who received STSG (8.71 ± 2.60 vs. 11.18 ± 2.84, p = 0.039). In conclusion, the BTM is effective and feasible in treating various wounds, with relatively low complication rates, and it can thus be considered as an alternative for skin and soft tissue reconstruction. When combined with adipofasical flap reconstruction, it achieves a more comprehensive anatomical restoration.

show abstract

Section: Discussionmentioning

confidence: 99%

Strategic Use of Biodegradable Temporizing Matrix (BTM) in Wound Healing: A Case Series in Asian Patients

Chen,

Lin,

Chang

et al. 2024

JFB

View full text Add to dashboard Cite

show abstract

“…Age: Patient age is a pivotal patient-specific factor that can influence the outcomes of skin grafting procedures. In the context of long-term scarring outcomes and the safety of patients treated with NovoSorbR Biodegradable Temporizing Matrix (BTM), a study revealed that age did not emerge as a significant factor affecting scarring outcomes [ 11 ]. Conversely, in a study focusing on lower limb skin graft failure, it was observed that the median age of participants, particularly at 79 years old, did not serve as an identified risk factor for graft failure [ 12 ].…”

Section: Reviewmentioning

confidence: 99%

“…In a study focused on assessing scar outcomes at donor sites following split-thickness skin grafting in burn patients, dermoscopy was employed to evaluate the long-term scarring outcomes [ 23 , 26 ]. The Patient and Observer Scar Assessment Scale (POSAS) was a comprehensive tool for evaluating scar quality, encompassing pigmentation, vascularity, pliability, and height [ 11 ]. Dermoscopy is valuable for monitoring the healing process and identifying potential complications, including hyperpigmentation, itching, infections, and scarring [ 3 ].…”

Section: Reviewmentioning

confidence: 99%

“…This imaging modality offers essential information about the thickness and vascularity of scar tissue, providing insights into the healing process and identifying potential complications [ 23 ]. In a study that evaluated the safety and scarring outcomes of patients treated with NovoSorbR Biodegradable Temporizing Matrix (BTM), ultrasound was employed to assess scar thickness, exemplifying its utility in objective measurements [ 11 ]. Moreover, ultrasound has been applied to evaluate the healing process and detect potential complications such as seroma formation and hematoma [ 17 ].…”

Section: Reviewmentioning

confidence: 99%

“…This method involves capturing photographs of the donor site at various stages of the healing process, facilitating the evaluation of healing progression and the identification of potential complications [ 23 , 27 ]. In a study that evaluated scar outcomes following split-thickness skin grafting, the POSAS was employed to assess scar quality, encompassing parameters such as pigmentation, vascularity, pliability, and height [ 11 ]. The strength of photo documentation lies in its versatility, as it can be used with other imaging techniques like dermoscopy and ultrasound to offer a more comprehensive assessment of donor site morbidity and scar outcomes [ 27 ].…”

Section: Reviewmentioning

confidence: 99%

See 2 more Smart Citations

A Comprehensive Review of Evaluating Donor Site Morbidity and Scar Outcomes in Skin Transfer Techniques

Manek,

Jajoo,

Mahakalkar

2024

Cureus

View full text Add to dashboard Cite

This comprehensive review delves into the intricacies of donor site morbidity and scar outcomes in skin transfer techniques central to the field of reconstructive surgery. The review synthesizes existing literature to illuminate the multifaceted factors influencing outcomes by surveying a broad spectrum of grafting methods, from traditional autografts to cutting-edge tissue engineering approaches. Key findings underscore the complex interplay of graft characteristics, surgical techniques, and patient-specific variables. The implications for clinical practice advocate for a nuanced, patient-centered approach, incorporating emerging minimally invasive procedures and adjuvant therapies. The review concludes with recommendations for future research, emphasizing the importance of longitudinal studies, comparative analyses, patient-reported outcomes, advanced imaging techniques, and exploration of tissue engineering innovations. This synthesis advances our understanding of donor site morbidity and scar outcomes. It provides a roadmap for refining clinical protocols, ultimately enhancing the delicate balance between therapeutic efficacy and patient well-being in reconstructive surgery.

show abstract

NovoSorb® Biodegradable Temporizing Matrix: a novel approach for treatment of extremity avulsion injuries in children

Najem,

Fattouh,

Wintges

et al. 2024

Eur J Trauma Emerg Surg

View full text Add to dashboard Cite

Purpose In pediatric population, large soft tissue defects occur in avulsion injuries. In addition to the challenges of primary surgical therapy, elasticity, appearance and function of the scar in children are of crucial importance, especially in the context of body growth. So far various flaps, plasties, skin grafts and dermal substitutes have become established, although infections and skin shrinkage remain challenging. In 2020, a new skin substitute material—NovoSorb® Biodegradable Temporizing Matrix (BTM)—was introduced in Europe for temporary wound closure and tissue regeneration. The aim of this study was to evaluate the value of BTM in pediatric patients. Methods The study included all children treated with BTM after traumatic soft tissue defects following limb avulsion injuries between June 2021 and June 2023 at a university hospital. Results 7 patients with limb avulsion injuries were treated with BTM, 4 boys, 3 girls. Mean age was 6.5 years (2–11 years) at the time of BTM placement. 4/7 had concomitant fractures. BTM was used successfully in all cases, infection did not occur, skin shrinkage was seen in one case. Split thickness skin graft (STSG) after BTM application was performed in average after 33 days (26 to 39 days). Limitations of this study were highlighted. Conclusion BTM is a promising alternative for reconstruction of complex trauma extremity wounds in children following avulsion injuries, even in cases of concomitant bone injuries. Interpretation may be limited by sample size.

show abstract

Long-term scarring outcomes and safety of patients treated with NovoSorbⓇ Biodegradable Temporizing Matrix (BTM): An observational cohort study

Cited by 5 publications

References 16 publications

Strategic Use of Biodegradable Temporizing Matrix (BTM) in Wound Healing: A Case Series in Asian Patients

Strategic Use of Biodegradable Temporizing Matrix (BTM) in Wound Healing: A Case Series in Asian Patients

A Comprehensive Review of Evaluating Donor Site Morbidity and Scar Outcomes in Skin Transfer Techniques

NovoSorb® Biodegradable Temporizing Matrix: a novel approach for treatment of extremity avulsion injuries in children

Contact Info

Product

Resources

About