2007
DOI: 10.1001/archderm.143.6.719
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Long-term Safety and Efficacy of 50 mg of Etanercept Twice Weekly in Patients With Psoriasis

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Cited by 296 publications
(316 citation statements)
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References 14 publications
(25 reference statements)
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“…It is a large (molecular weight of 150 000 Da) fusion protein that consists of extracellular region of human TNF-R2 fragment coupled to an Fc region of human IgG that binds to transmembrane TNF-a and acts as a decoy receptor (Mohler et al, 1993). Etanercept is clinically used in the treatment of RA and psoriasis, via subcutaneous administration (Hunt and Emery, 2013;Tyring et al, 2007), and reduces co-morbidities of depression and cognitive impairment (Kekow et al, 2011;Tyring et al, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…It is a large (molecular weight of 150 000 Da) fusion protein that consists of extracellular region of human TNF-R2 fragment coupled to an Fc region of human IgG that binds to transmembrane TNF-a and acts as a decoy receptor (Mohler et al, 1993). Etanercept is clinically used in the treatment of RA and psoriasis, via subcutaneous administration (Hunt and Emery, 2013;Tyring et al, 2007), and reduces co-morbidities of depression and cognitive impairment (Kekow et al, 2011;Tyring et al, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Results at 24 weeks were similar for patients originally treated with etanercept or with placebo. PASI-75 at 48 weeks was 62%, whereas this was 51% at 96 weeks [49].…”
Section: Efficacy Etanerceptmentioning
confidence: 85%
“…In the 3 studies judged by EMA [23][24][25] A more recent study compared etanercept and placebo in children and adolescents [49]. The double blind phase lasted for 12 weeks, after which all patients received weekly etanercept for 24 weeks.…”
Section: Efficacy Etanerceptmentioning
confidence: 99%
“…Tampoco se han detectado cambios en la hepatopatía cróni-ca en los dos casos descritos de pacientes VHC+ en tratamiento con ustekinumab 42 .…”
Section: Contraindicaciones Absolutasunclassified
“…Todos los casos experimentaron mejoría al interrumpir el tratamiento 42 . Durante los ensayos con ustekinumab, no se registró ningún caso de enfermedad desmielinizante.…”
Section: Contraindicaciones Absolutasunclassified