2016
DOI: 10.3171/2015.2.jns142144
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Long-term safety and efficacy of Gamma Knife surgery in classical trigeminal neuralgia: a 497-patient historical cohort study

Abstract: OBJectiVe Gamma Knife surgery (GKS) is one of the surgical alternatives for the treatment of drug-resistant trigeminal neuralgia (TN). This study aims to evaluate the safety and efficacy of GKS in a large population of patients with TN with very long-term clinical follow-up. methOdS Between July 1992 and November 2010, 737 patients presenting with TN were treated using GKS. Data were collected prospectively and were further retrospectively evaluated at Timone University Hospital. The frequency and severity of … Show more

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Cited by 147 publications
(139 citation statements)
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“…In 2010, Kondziolka et al [6] published a series from Pittsburgh, with a rather low rate of hypesthesia (10.5%) and a 10-year rate of 29% of patients who were pain free without medication. We recently reported our results [11] in a series of 497 patients with more than one-year follow-up (median = 43.8 months, range = 28.1-93.2). After a very good initial response (91.75%), 45.3% of patients were still pain free without medication at 10 years.…”
Section: Discussionmentioning
confidence: 99%
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“…In 2010, Kondziolka et al [6] published a series from Pittsburgh, with a rather low rate of hypesthesia (10.5%) and a 10-year rate of 29% of patients who were pain free without medication. We recently reported our results [11] in a series of 497 patients with more than one-year follow-up (median = 43.8 months, range = 28.1-93.2). After a very good initial response (91.75%), 45.3% of patients were still pain free without medication at 10 years.…”
Section: Discussionmentioning
confidence: 99%
“…The current literature includes few studies with long-term follow-up [6,7,10,11]. In chronological order, in 2009, Dhople et al [10] reported a series of 102 patients with a median follow-up period of 5.6 years.…”
Section: Discussionmentioning
confidence: 99%
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“…However, with the advent of stereotaxis and better targeting over time at the dorsal root entry zone, 19,20 retrogasserian gamma knife surgery (GKS) has become a safe and efficacious modality for the treatment of TN for both first-and second-line treatment given its low side-effect profile, avoidance of open surgery, and patient satisfaction. 21,22 This involves using photon energy to create a destructive lesion using focused radiation to injure the sensory root. Although initial pain relief can be achieved in up to 90% of cases, patients typically do not experience immediate posttreatment pain relief because of a lag time ranging from 1 to 3 months.…”
Section: Stereotactic Radiosurgerymentioning
confidence: 99%