Long‐Term Safety and Effectiveness of Drug‐Eluting Stents Compared to Bare Metal Stents in ST Elevation Myocardial Infarction: Findings from the Guthrie Health Off‐Label Stent (GHOST) Registry

Sattur, Sudhakar; Orshaw, Pam; Boura, Judy; Harjai, Kishore J.

doi:10.1111/j.1540-8183.2011.00703.x

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…First, as a single-center study, there is a question about whether these results can be extrapolated. Long-term data from realworld reports describe results similar to those we have found (5-year mortality rates between 15 and 25 % and recurrent MI as high as 23 %) [25][26][27][28][29][30]. The long-term prevalence of ST published in the literature varies and depends on aspects such as the definition and type of ST, the study era, the antiplatelet therapy strategy used, and the proportion of acute patients.…”

Section: Limitationssupporting

confidence: 72%

Timing and long-term prognosis of recurrent MI after primary angioplasty

Monteiro

Ramos

Fiarresga

et al. 2016

Herz

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Section: Limitationssupporting

confidence: 72%

Timing and long-term prognosis of recurrent MI after primary angioplasty

Monteiro

Ramos

Fiarresga

et al. 2016

Herz

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Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes

Oddi

Bari

Battista

et al. 2005

CMLS, Cell. Mol. Life Sci.

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The signaling activity of anandamide (AEA) is terminated by its uptake across the cellular membrane and subsequent intracellular hydrolysis by the fatty acid amide hydrolase (FAAH). To date, the existence of an AEA membrane transporter (AMT) independent of FAAH activity remains questionable, although it has been recently corroborated by pharmacological and genetic data. We performed confocal microscopy and biochemical analysis in human HaCaT keratinocytes, in order to study the cellular distribution of AMT and FAAH. We found that FAAH is intracellularly localized as a punctate staining partially overlapping with the endoplasmic reticulum. Consistently, subcellular fractionation and reconstitution of vesicles from membranes of different compartments demonstrated that FAAH activity was localized mainly in microsomal fractions, whereas AMT activity was almost exclusively in plasma membranes. These results provide the first morphological and biochemical evidence to support the view that transport and hydrolysis are two spatially and functionally distinct processes in AEA degradation.

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Comparison of treatment outcomes of ticagrelor and clopidogrel among patients undergoing percutaneous coronary intervention: A meta-analysis

2017

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We performed a meta-analysis of randomized controlled trials (RCTs) to investigate the efficacy and safety of ticagrelor (TIC) vs. clopidogrel (CLO) in patients undergoing percutaneous coronary intervention (PCI). In Jun 2016, a literature search was started and all the studies were conducted from 2010 to 2015. We systematically searched the literature through the MEDLINE database, Cochrane library, and EMBASE database. Quality assessments were evaluated with Jadad quality scale. Data were extracted considering the characteristics of efficacy and safety designs. Six RCTs enrolling 26 244 participants and satisfying the inclusion criteria were finally analyzed. There was a significant decrease of all-cause mortality (MD=0.83, 95%CI=0.74-0.93, P=0.001) and myocardial infarction (MI) (MD=0.78, 95%CI=0.70-0.88, P=0.000). There were no significant differences in stroke (MD=1.34, 95%CI=0.99-1.79, P=0.06), total bleeding (MD=0.97, 95%CI=0.84-1.12, P=0.66), minor or major bleeding (MD=1.06, 95%CI=0.94-1.19, P=0.35) in patients undergoing PCI after treatment with TIC vs. CLO. TIC could be more significant in decreasing all-cause mortality and MI than CLO, but there were no significant differences between TIC and CLO in inhibiting stroke, major bleeding, major or minor bleeding in patients undergoing PCI.

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Long‐Term Safety and Effectiveness of Drug‐Eluting Stents Compared to Bare Metal Stents in ST Elevation Myocardial Infarction: Findings from the Guthrie Health Off‐Label Stent (GHOST) Registry

Abstract: In our study of STEMI patients, DES implantation was safer than BMS implantation and was associated with lower MACE at long-term follow-up.

Cited by 4 publications

References 20 publications

Timing and long-term prognosis of recurrent MI after primary angioplasty

Timing and long-term prognosis of recurrent MI after primary angioplasty

Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes

Comparison of treatment outcomes of ticagrelor and clopidogrel among patients undergoing percutaneous coronary intervention: A meta-analysis

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