Long-term risk of mesenteric ischemia in patients with inflammatory bowel disease: a 13-year nationwide cohort study in an Asian population

Tsai, Ming-Shian; Lin, Cheng‐Li; Chen, Hsin-Pao; Lee, Po‐Huang; Sung, Fung‐Chang; Kao, Chia‐Hung

doi:10.1016/j.amjsurg.2014.08.026

Cited by 26 publications

(24 citation statements)

References 36 publications

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“…All included studies were published recently; the publication year ranged from 2008 to 2015. Of the 10 studies, 3 were performed in the United Kingdom, 1 from Taiwan, 2 from the United States, 2 from Denmark, 1 from Canada, and 1 from Sweden . All identified studies were published in English.…”

Section: Resultsmentioning

confidence: 99%

“…Our finding was supported by most studies but not all. Among these 10 studies, 7 studies suggested an elevated risk of IHD in patients with IBD . However, 3 studies did not find such association .…”

Section: Discussionmentioning

confidence: 98%

“…Among included studies, disease severity was prospectively assessed using frequency of hospitalization or initiation of biological and glucocorticoids treatment. Their observations suggested that the inflammatory activity was associated with an increased risk of CVD . A population‐based cohort study reported an elevated risk of MI in the flare and persistent IBD activity period, whereas no increased risk of MI was observed during the remission period .…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Since the publication of a previous meta-analysis, several studies have been published that have not been synthesized with existing data. [20][21][22][23] We aimed to examine the relation between IBD and risk of IHD by updating the previous meta-analysis.…”

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confidence: 99%

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Inflammatory Bowel Disease and Risk of Ischemic Heart Disease: An Updated Meta‐Analysis of Cohort Studies

Feng

Chen

Cai

et al. 2017

JAHA

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BackgroundSeveral immune‐mediated diseases have been shown to be associated with an increased risk of cardiovascular disease. However, studies evaluating the association between inflammatory bowel disease and risk of cardiovascular disease reported inconsistent results. We assessed the association between inflammatory bowel disease and risk of ischemic heart disease in a meta‐analysis of cohort studies.Methods and ResultsWe conducted a literature search of PubMed and Embase up to October 2016 to identify relevant studies. The summary relative risks were calculated using the random‐effects models. To explore the source of heterogeneity, we performed subgroup and sensitivity analysis. We included 10 cohort studies that satisfied our inclusion criteria. Patients with inflammatory bowel disease were associated with an increased risk of ischemic heart disease (relative risk: 1.244; 95% CI, 1.142–1.355). Considerable heterogeneity was observed. Crohn's disease showed a significantly increased risk of ischemic heart disease (relative risk=1.243; 95% CI, 1.042–1.482) and a positive association was also observed in ulcerative colitis (relative risk=1.206; 95% CI, 1.170–1.242).ConclusionsBased on meta‐analysis of cohort studies, we found an increased risk of ischemic heart disease in patients with inflammatory bowel disease. Large long‐term prospective studies are warranted to confirm our results.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Inflammatory Bowel Disease and Risk of Ischemic Heart Disease: An Updated Meta‐Analysis of Cohort Studies

Feng

Chen

Cai

et al. 2017

JAHA

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“…It accounts 1:1000 acute hospital admissions in Europe and the USA [1] and presents a very high mortality with a range from 50 to 69% [2–5] of cases.…”

Section: Introductionmentioning

confidence: 99%

An investigation of bedside laparoscopy in the ICU for cases of non-occlusive mesenteric ischemia

et al. 2017

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BackgroundAcute mesenteric ischemia is a rare affection with high related mortality. NOMI presents the most important diagnostic problems and is related with the higher risk of white laparotomy. This study wants to give a contribution for the validation of laparoscopic approach in case of NOMI.MethodsThirty-two consecutive patients were admitted in last 10 years in ICU of Paolo Giaccone University Hospital of Palermo for AMI. Diagnosis was obtained by multislice CT and selective angiography was done if clinical conditions were permissive. If necrosis was already present or suspected, surgical approach was done. Endovascular or surgical embolectomy was performed when necessary. Twenty NOMI patients underwent medical treatment performing laparoscopy 24 h later to verify the evolution of AMI. A three-port technique was used. In all patients we performed a bed side procedure 48–72 h later in both non-resected and resected group.ResultsIn 14 up 20 case of NOMI the disease was extended throughout the splanchnic district, in 6 patients it involved the ileum and the colon; after a first look, only 6 patients underwent resection. One patient died 35 h after diagnosis of NOMI. The second look, 48 h later, demonstrated 4 infarction recurrences in the group of resected patients and onset signs of necrosis in 5 patients of non-resected group. A total of 15 resections were performed on 11 patients. Mortality rate was 6/20–30% but it was much higher in resected group (5/11–45,5%). Non-therapeutic laparotomy was avoided in 9/20 patients and in this group mortality rate was 1/9–11%. No morbidity was recorded related to laparoscopic procedure.ConclusionsLaparoscopy could be a feasible and safety surgical approach for management of patient with NOMI. Our retrospective study demonstrates that laparoscopy don’t increase morbidity, reduce mortality avoiding non-therapeutic laparotomy.

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Study of ischemic progression in different intestinal tissue layers during acute intestinal ischemia using swept‐source optical coherence tomography angiography

Tian,

Zhang,

Man

et al. 2024

Journal of Biophotonics

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In acute intestinal ischemia, the progression of ischemia varies across different layers of intestinal tissue. We established a mouse model and used swept‐source optical coherence tomography (OCT) to observe the intestinal ischemic process longitudinally in different tissue layers. Employing a method that combines asymmetric gradient filtering with adaptive weighting, we eliminated the vessel trailing phenomenon in OCT angiograms, reducing the confounding effects of superficial vessels on the imaging of deeper vasculature. We quantitatively assessed changes in vascular perfusion density (VPD), vessel length, and vessel average diameter across various intestinal layers. Our results showed a significant reduction in VPD in all layers during ischemia. The mucosa layer experienced the most significant impact, primarily due to disrupted capillary blood flow, followed by the submucosa layer, where vascular constriction or decreased velocity was the primary factor.

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Long-term risk of mesenteric ischemia in patients with inflammatory bowel disease: a 13-year nationwide cohort study in an Asian population

Cited by 26 publications

References 36 publications

Inflammatory Bowel Disease and Risk of Ischemic Heart Disease: An Updated Meta‐Analysis of Cohort Studies

Inflammatory Bowel Disease and Risk of Ischemic Heart Disease: An Updated Meta‐Analysis of Cohort Studies

An investigation of bedside laparoscopy in the ICU for cases of non-occlusive mesenteric ischemia

Study of ischemic progression in different intestinal tissue layers during acute intestinal ischemia using swept‐source optical coherence tomography angiography

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