Long-term Results With CorMatrix Extracellular Matrix Patches After Carotid Endarterectomy

Selection criteria for patch angioplasty material in carotid endarterectomy

“…The standard of care to conduct patch angioplasty or primary closure CEA remains unclear, and the ideal materials that may provide significant advantage are still being researched. [ 32 , 35 , 38 ] Several materials that are commonly used for patch angioplasty CEA include autologous vein, synthetic materials (expanded polytetrafluoroethylene and Dacron), and biologic patches (bovine pericardium and decellularized extracellular matrix). [ 35 , 38 ] Nevertheless, evidence supporting the superiority of one material is lacking, and ongoing research aimed at discovering the “holy grail” material is still ongoing.…”

“…[ 32 , 35 , 38 ] Several materials that are commonly used for patch angioplasty CEA include autologous vein, synthetic materials (expanded polytetrafluoroethylene and Dacron), and biologic patches (bovine pericardium and decellularized extracellular matrix). [ 35 , 38 ] Nevertheless, evidence supporting the superiority of one material is lacking, and ongoing research aimed at discovering the “holy grail” material is still ongoing. [ 49 ] There is no specific guidance on the ideal criteria that needed to be fulfilled by a selected material.…”

“…Yet, the outcome of this patch has only been reported by a single-center study; thus, further research examining this particular material is needed. [ 35 ]…”

Surgical Reconstruction of a Left Ventricular Aneurysm Using an Extracellular Matrix Patch

“…There is no evidence of long-term results after LV reconstruction using an extracellular matrix patch. McCready et al present long-term results after carotid artery reconstruction using multilayer extracellular patch to increase 0.3% of new formed pseudoaneurysms during 72 of months follow-up [ 11 ] .…”

Pathological Changes of Adult Mitral Valves after Failed CorMatrix ECM Repair

“…However, more recent data, especially from clinical studies with larger subject numbers, suggested a significant number of re-operations after CorMatrix ECM repair. 10 , 17 , 18 In contrast to successful arterial reconstruction, 19 , 20 histological examination of the tissues that were collected during the valve re-operation revealed intense chronic inflammation, a lack of significant resorption of the implanted material, and little or no remodeling into a structure that resembled native valve tissue, in contrast to the manufacturer’s claims. 2 , 21 This inconclusive clinical data requires careful histological examination.…”