Long term results using local excision after preoperative chemoradiation among selected T3 rectal cancer patients

Bonnen, Mark; Crane, Christopher; Feig, Barry W.; Skibber, John M.; Ballo, Matthew T.; Delclos, Marc E.; Brown, Tiffany C.; Wong, Angelique; Phan, Thinh; Janjan, Nora A.

doi:10.1016/s0360-3016(01)01845-4

Cited by 27 publications

(30 citation statements)

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“…Protocolos utilizando RT/ QT apresentaram taxas de controle local do tumor primário entre 50 e 100%, dependendo do tamanho e do estádio do tumor. 19,23,28,38 Nossa casuística mostrou taxa de 100% em doentes nos estádios I e II e de 75% nos estádios IIIa e IIIb.…”

Section: Discussionunclassified

“…17 Para tanto, solicitamos exames de imagem como ultrassonografia endoanal, tomografia computadorizada ou ressonância nuclear magnética. 19 As metástases ocorrem entre 10 e 15% dos casos, sendo o fígado e os pulmões os órgãos mais atingidos, o que constitui motivo para sua avaliação. 20 O tratamento desse tumor atravessou profunda transformação nos últimos 20 anos.…”

Section: Departamento De Cirurgia Da Faculdade De Ciências Médicas Daunclassified

“…Apresenta efeitos colaterais tóxicos, locais e sistêmicos, que incluem mielossupressão, dificuldade de cicatrização, alterações da função esfincteriana, dermatite, fístula e mucosite, que são mais intensos nos doentes imunodeprimidos. 29 O atual esquema, proposto para tratamento dos CEC anais, é considerado efetivo e apresenta sobrevivência de 5 anos entre 68 e 86% 19,21,25,26 e de 10 anos de 75%. 28 As recidivas ocorrem entre 8 e 21%, porém são passíveis de cura com procedimentos operatórios.…”

Section: Departamento De Cirurgia Da Faculdade De Ciências Médicas Daunclassified

“…28 As recidivas ocorrem entre 8 e 21%, porém são passíveis de cura com procedimentos operatórios. 19,21,26 Entretanto, o estádio da doença é fator prognóstico para aumento da sobrevivência. 26 Os exames complementares são fundamentais no seguimento pós-tratamento, para diagnóstico das recidivas locorregionais ou metástases .…”

Section: Departamento De Cirurgia Da Faculdade De Ciências Médicas Daunclassified

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Avaliação dos resultados do tratamento de 14 doentes de carcinoma espinocelular anal

Lap¹,

Sha²,

Dl³

et al. 2006

Rev bras. colo-proctol.

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Section: Discussionunclassified

Section: Departamento De Cirurgia Da Faculdade De Ciências Médicas Daunclassified

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Avaliação dos resultados do tratamento de 14 doentes de carcinoma espinocelular anal

Lap¹,

Sha²,

Dl³

et al. 2006

Rev bras. colo-proctol.

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show abstract

“…Hay un subgrupo de pacientes en los que en el estudio de la pieza operatoria se demuestra que no hay tumor en la pared rectal: respuesta mural completa (RMC), pero hay presencia de metástasis ganglionares. Este hallazgo se observa en el 2 a 17% de aquellos con RMC 7,8. Varios estudios sugieren fuertemente que la RPC se relaciona con un mejor control local de la enfermedad, sobrevida libre de enfermedad y sobrevida global 5,9,10 . Desafortunadamente la RPC y RMC son conocidos cuando se obtiene el estudio histopatológico de la pieza operatoria y el único elemento que pudiera anticipar una RPC o una RMC es el examen endoscópico de la lesión, 6 a 8 semanas después de terminada la XRTQ.…”

Section: Respuesta Patológica Completa En Pacientes Sometidos a Neoadunclassified

Respuesta patológica completa en pacientes sometidos a neoadyuvancia en cáncer de recto

et al. 2013

Rev Chil Cir

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Pathologic complete response in patients with neoadjuvant chemoradiotherapy for rectal cancer Background: The standard treatment of locally advanced rectal cancer (RC) of the middle and lower third of the rectum is neoadjuvant chemoradiotherapy (XRQT) follow by oncologic resection. After this treatment in 15-25% of the cases, the pathologist reports complete pathological response (pCR). Aim: To describe demographic, clinical and survival data of patients with pCR undergoing chemoradiotherapy and radical resection for RC. Material and Methods: Historic cohort study. In a prospectively maintained database between 2000 and 2010, we identified patients with RC, who underwent neoadjuvant chemoradiotherapy according to protocol, followed by radical resection. The preoperative staging was obtained by clinical examination, endoscopy, rectal ultrasound, CT scan of chest, abdomen and pelvis and pelvic MRI. Demographic data, tumor location, time between the end of XRTQ and surgery, postoperative staging (according AJCC) and survival, were collected. Results: 119 patients received preoperative XRTQ, 65% male, with a mean age of 58 years. The most frequent tumor site was the lower third (63%). Surgery was performed 8 weeks after the end of XRTQ. Of 119 patients with XRTQ, 15.1% had a pCR. Overall survival was 75%, and cancerspecific survival was 80.4% at 5 years in patients without pCR. For patients with pCR, the 5 year survival estimates for overall and cancer specific survival was 100%. We did not identify factors associated with pCR. Conclusions: In this study, pCR was comparable to other larger series reported elsewhere. No factors associated with pCR were identified.Key words: Pathological complete response, rectal cancer, neoadjuvant chemoradiotherapy. ResumenIntroducción: El cáncer de recto (CR) de tercio medio e inferior localmente avanzado se trata con radio-quimioterapia (XRTQ) preoperatoria. Luego XRQT y resección quirúrgica, 15-25% presentan respuesta patológica completa (RPC) de la lesión. Objetivo: Comparar características demográficas, clínicas y sobrevi-

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Skull Anatomy of the Bizarre Crocodylian Mourasuchus nativus (Alligatoridae, Caimaninae)

Bona

Degrange

Fernández

2012

The Anatomical Record

105

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Mourasuchus is a Miocene alligatorid endemic to South America, and is represented by four species. Together with the closely related Purussaurus, it is a peculiar crocodylian taxon of neogene Caimaninae and one of the most bizarre forms among eusuchian crocodiles. The phylogenetic relationships between Mourasuchus species have not been explored, and detailed skull descriptions are scarce. The goal of this study is to provide new data on skull morphology and cranial recesses in Mourasuchus nativus, including a new tomography analysis (3D modeling). We observed that several diagnostic characters of Purussaurus, such as lack of contact between the nasal and lacrimal, separation of the nasal and frontal by the prefrontals, and the posterior dorsal margin of the skull table, are shared with Mourasuchus. M. nativus is characterized by the presence of solid transverse squamosal eminences, large posttemporal fenestrae, and a quadrate laterocaudal bridge separating V 2 -V 3 trigeminal openings. Compared with other crocodylians, the endocast of M. nativus is similar in shape but quite sigmoid in lateral view, the canal of the supraorbital ramus of V 2 is more vertically oriented, the thick tympanic branch canal opens in a large foramen aligned with trigeminal foramen, and the canal of the vagal (X) tympanic ramus is also very wide. Contrary to extant alligatorids, the median pharyngeal recess remains paired throughout its course and only connects its opposite fellow near the external ventral opening. The knowledge of the internal skull anatomy of Mourasuchus contributes to the understanding of the general morphology of alligatorids, Caimaninae, and their variation. Anat Rec,

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Long term results using local excision after preoperative chemoradiation among selected T3 rectal cancer patients

Cited by 27 publications

References 0 publications

Avaliação dos resultados do tratamento de 14 doentes de carcinoma espinocelular anal

Avaliação dos resultados do tratamento de 14 doentes de carcinoma espinocelular anal

Respuesta patológica completa en pacientes sometidos a neoadyuvancia en cáncer de recto

Skull Anatomy of the Bizarre Crocodylian Mourasuchus nativus (Alligatoridae, Caimaninae)

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