Long-term results of treatment of cervical carcinoma in the United States in 1973, 1978, and 1983: Patterns of Care Study (PCS)

Komaki, Ritsuko; Brickner, Theodore J.; Hanlon, Alexandra L.; Owen, Jean B.; Hanks, Gerald E.

doi:10.1016/0360-3016(94)00489-7

Cited by 82 publications

(24 citation statements)

References 21 publications

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“…7,10,12 In the large LDR series, the 5-year PC and OS rates were approximately 90% and 80%, respectively, for patients with Stage IB disease, 70 -80% and 60 -70%, respectively, for patients with Stage II disease, and 50 -70% and 30 -50%, respectively, for patients with Stage III disease. [22][23][24][25][26] The outcomes achieved in the current series therefore were comparable to those of the large LDR series. The strong correlation between tumor size and treatment outcome is well documented.…”

Section: Discussionsupporting

confidence: 68%

“…The strong correlation between tumor size and treatment outcome is well documented. 5,[22][23][24][25][26] The variation of treatment results among the different reports may be due to the wide range of tumor sizes, even for patients with the same stage of disease. The number of bulky tumors in our patient population was relatively small compared with the number of tumors in the American and European series, 22,23 and this might account for the more favorable outcome.…”

Section: Discussionmentioning

confidence: 99%

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Long‐term results of high‐dose rate intracavitary brachytherapy for squamous cell carcinoma of the uterine cervix

Nakano

Kato

Ohno³

et al. 2004

Cancer

146

100

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BACKGROUNDThe authors performed a long‐term follow‐up study to evaluate the efficacy and late toxicity of high‐dose rate intracavitary brachytherapy (HDR‐ICBT) for cervical carcinoma.METHODSFrom 1968 to 1986, 1148 patients with Stage IB to IVB squamous cell carcinoma of the cervix (staging was performed according to the International Federation of Gynecology and Obstetrics) were treated with a combination of external beam radiotherapy (EBRT) and HDR‐ICBT. For patients with early‐stage disease, 20 gray (Gy) of EBRT was delivered to the whole pelvis, followed by 24 Gy/4 fractions of HDR‐ICBT and 30 Gy of central‐shielding EBRT. For patients with advanced‐stage disease, 20–40 Gy of whole pelvic EBRT was administered, followed by 24 Gy/4 fractions of ICBT and 30–10 Gy of central‐shielding EBRT. The overall treatment time was approximately 6 weeks. Among survivors, the follow‐up rate was 98% and the median follow‐up duration was 22 years.RESULTSThe 10‐year pelvic tumor control rates were 93% for patients with Stage IB disease, 82% for patients with Stage II disease, and 75% for patients with Stage III disease. The 10‐year overall and cause‐specific survival rates were 74% and 89% for patients with Stage IB disease, 52% and 74% for patients with Stage II disease, and 42% and 59% for patients with Stage III disease, respectively. The 10‐year actuarial rates of major complications were 4.4% in the rectosigmoid colon, 0.9% in the bladder, and 3.3% in the small intestines.CONCLUSIONSThe results of the current study suggest that the combination of EBRT and HDR‐ICBT according to the authors' protocol provided outcomes that were comparable to those of the conventional low‐dose rate brachytherapy with acceptable rates of late complications in the treatment of cervical carcinoma. Cancer 2005. © 2004 American Cancer Society.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Long‐term results of high‐dose rate intracavitary brachytherapy for squamous cell carcinoma of the uterine cervix

Nakano

Kato

Ohno³

et al. 2004

Cancer

146

100

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“…Most investigators correlated tumor size and stage with the 5-year survival (5)(6)(7)(8)(9)(10)(11)(12). Bulky tumor was defined as Ͼ6 cm (32,55).…”

Section: Discussionmentioning

confidence: 99%

“…The combination of external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT) is considered the standard of care, except in younger patients with early-stage disease. Many large series have reported 5-year disease-free survival (DFS) rates of 80 -90% for Stage I, 55-70% for Stage II, 30 -50% for Stage III, and 10 -15% for Stage IV disease (5)(6)(7)(8)(9)(10)(11)(12). Conventional ICBT with tandem and ovoids or ovoids alone may not deliver an adequate dose in cases of extensive and bulky tumors, obliterated fornices, lower vaginal involvement, and carcinoma of the cervical stump (13,14).…”

Section: Introductionmentioning

confidence: 99%

Long-term results of low-dose-rate interstitial-intracavitary brachytherapy in the treatment of carcinoma of the cervix

Syed

Puthawala

Abdelaziz

et al. 2002

International Journal of Radiation Oncology*Biology*Physics

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“…Despite worldwide efforts at screening with the aim of detecting cervical cancer in the early stage, many cancers are not discovered until already advanced. Traditionally, radical hysterectomy or radiation therapy alone has been accepted as standard treatment for early-stage invasive cervical cancer, and locally advanced cancer has been treated by radiotherapy alone consisting of a combination of high-dose-rate intracavitary brachytherapy (ICBT) and external beam radiotherapy (EBRT) (Coia et al, 1990;Komaki et al, 1995;Barillot et al, 1997). In the past few years, substantial advances in the management of locally advanced cervical cancer have been reported.…”

mentioning

confidence: 99%

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

et al. 2007

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The objective of this retrospective study was to determine the survival rate, incidence of late complications, and incidence of second cancers when radiation therapy alone is used for carcinoma of the uterine cervix. Between 1971 and 1995, 1495 patients with squamous cell carcinoma of the uterine cervix (stages I -IV) were treated with radiation therapy alone in our hospital. Radiation therapy consisted of a combination of high-dose-rate intracavitary brachytherapy and external beam radiotherapy. The cumulative 5-year survival rates for stages Ib, II, and III/IVa carcinoma were 93.5, 77.0, and 60.3%, respectively, and the 10-year survival rates were 90.9, 74.5, and 56.1%, respectively. Local control rates for stages Ib, II, and III/IVa carcinoma were 92.0, 79.4 and 64.2%, respectively. Eighty-two (5.5%) patients suffered grade III/IV or V (fatal) complications. A second cancer developed in 13 (0.87%) patients. Second cancers were observed most frequently in the rectum (five cases), colon (three cases), and uterine body (two cases). Long-term follow-up data revealed that our method of radiation therapy alone for locally advanced carcinoma of the uterine cervix is effective, with low incidences of late complications and second cancers.

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Long-term results of treatment of cervical carcinoma in the United States in 1973, 1978, and 1983: Patterns of Care Study (PCS)

Cited by 82 publications

References 21 publications

Long‐term results of high‐dose rate intracavitary brachytherapy for squamous cell carcinoma of the uterine cervix

Long‐term results of high‐dose rate intracavitary brachytherapy for squamous cell carcinoma of the uterine cervix

Long-term results of low-dose-rate interstitial-intracavitary brachytherapy in the treatment of carcinoma of the cervix

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

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