Long-Term Results of Treatment of 283 Patients with Lung and Bone Metastases from Differentiated Thyroid Carcinoma

Schlumberger, Martin; Tubiana, M; Vathaire, Florent de; Hill, Catherine; Gardet, P; Travagli, Jean-Paul; Fragu, P.; Lumbroso, J.; Caillou, Bernard; Parmentier, C

doi:10.1210/jcem-63-4-960

Cited by 457 publications

(51 citation statements)

References 19 publications

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“…The proponents for more radical surgery (total or subtotal) thyroidectomy are based on theoretical disease control benefits: (1) papillary carcinoma and its subtypes are frequently multifocal; (2) there is a reduced incidence of local and distant recurrence; (3) reduced risk of anaplastic transformation in the thyroid remnant, and (4) it facilitates of post-thyroidectomy monitoring by 131 I scan and serum Tg levels [9]. In addition, residual thyroid tissue after lobectomy may interfere with the use of radioactive iodine in the treatment of microscopic regional and distant disease.…”

Section: Discussionmentioning

confidence: 99%

Differentiated Thyroid Carcinoma in Children and Adolescents

Arıcı

Erdoğan²,

Altunbaş³

et al. 2002

Horm Res Paediatr

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Background: Thyroid carcinoma in childhood and adolescence is uncommon and because of the slow progression of disease the standard treatment is controversial. The aim of this study was to perform a retrospective analysis of treatment results for differentiated thyroid carcinoma in this age group treated in our clinic. Material and Methods: From August 1988 to February 2001, 15 patients between the ages of 8 and 21 years (average 16.8) were treated for differentiated thyroid carcinoma at Akdeniz University Medical School Departments of General and Pediatric Surgery. The patients included 10 (67%) females and 5 (33%) males. None of the patients had a previous positive history of head and neck irradiation. All patients, except 2, were euthyroid at the time of diagnosis. Results: Nine of the patients underwent total thyroidectomy and in 6 cases subtotal thyroidectomy was performed. There were multiple lymph node metastases in 4 (27%) patients and (various forms of) cervical lymph node dissections were performed in these patients. In addition, 2 children (13%) showed pulmonary metastasis. The incidence of surgical complications was 20% (1 permanent, 1 transient hypoparathyroidism and 1 permanent laryngeal nerve injury). Histological examinations revealed the following: papillary carcinoma in 9 (60%), follicular carcinoma in 5 (33%) patients, and Hurthle cell carcinoma in 1 (7%) patient. Postoperative radioiodine ablation was also added to treatment in 10 (67%) of the patients and all patients received L-thyroxine in suppressive doses. After a median follow-up period of 57 months (range 5–149), all patients are alive and disease-free. Conclusion: Our observations suggest that although most children and adolescents with differentiated thyroid carcinoma are seen with more extensive disease than adults, a total or subtotal thyroidectomy with an appropriate lymph node dissection followed by ablative radioiodine treatment carries a more favorable prognosis.

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Section: Discussionmentioning

confidence: 99%

Differentiated Thyroid Carcinoma in Children and Adolescents

Arıcı

Erdoğan²,

Altunbaş³

et al. 2002

Horm Res Paediatr

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“…The 10-year survival rate following the detection of bone metastasis is less than 20%. 113,117 Thyroid carcinoma bone metastases typically have an osteolytic phenotype; however, it is believed that osteoblastic metastasis of thyroid carcinomas may have a better prognosis. 1 …”

Section: Animal Modelsmentioning

confidence: 99%

Animal Models of Bone Metastasis

et al. 2015

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Bone is one of the most common sites of cancer metastasis in humans and is a significant source of morbidity and mortality. Bone metastases are considered incurable and result in pain, pathologic fracture, and decreased quality of life. Animal models of skeletal metastases are essential to improve the understanding of the molecular pathways of cancer metastasis and growth in bone and to develop new therapies to inhibit and prevent bone metastases. The ideal animal model should be clinically relevant, reproducible, and representative of human disease. Currently, an ideal model does not exist; however, understanding the strengths and weaknesses of the available models will lead to proper study design and successful cancer research. This review provides an overview of the current in vivo animal models used in the study of skeletal metastases or local tumor invasion into bone and focuses on mammary and prostate cancer, lymphoma, multiple myeloma, head and neck squamous cell carcinoma, and miscellaneous tumors that metastasize to bone.

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“…However, because 4-7% of patients present initially with distant metastasis (Schlumberger et al 1986, Shaha et al 1997, and surgery is the only therapeutic option for thyroid cancer, advocating the routine use of PET to detect distant metastasis is inappropriate. In addition, because PET scanners have limited spatial resolution, nodules in the lung smaller than 5 mm may be missed (Jeong et al 2006a).…”

Section: Preoperative Assessment Of Thyroid Cancer With Fdg Petmentioning

confidence: 99%

The role of 18F-fluorodeoxyglucose positron emission tomography in differentiated thyroid cancer before surgery

Pak¹,

Kim²,

Kim³

et al. 2013

Endocrine-Related Cancer

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The incidence of thyroid cancer in both men and women is increasing faster than that of any other cancer. Although positron emission tomography (PET) using 18 F-fluorodeoxyglucose (FDG) has received much attention, the use of FDG PET for the management of thyroid cancer is limited primarily to postoperative follow-up. However, it might have a role in selected, more aggressive pathologies, and so patients at a high risk of distant metastasis may benefit from PET before surgery. As less FDG-avid thyroid cancers may lower the diagnostic accuracy of PET in preoperative assessment, an understanding of FDG avidity is important for the evaluation of thyroid cancer. FDG avidity has been shown to be associated with tumor size, lymph node metastasis, and glucose transporter expression and differentiation. As PET is commonly used in clinical practice, the detection of incidentalomas by PET is increasing. However, incidentalomas detected by PET have a high risk of malignancy. Clinicians handling cytologically indeterminate nodules face a dilemma regarding a procedure for a definitive diagnosis, usually lobectomy. With 'nondiagnostic (ND)' fine-needle biopsy (FNA), PET has shown a negative predictive value (NPV) of 100%, which indicates that negative uptake in a ND FNA procedure accurately excludes malignancy. With 'atypia of undetermined significance' or 'follicular neoplasm', the sensitivity and NPV of PET are 84 and 88%. PET does not provide additional information for the preoperative assessment of thyroid cancer. However, factors associated with FDG positivity are related to a poor prognosis; therefore, FDG PET scans before surgery may facilitate the prediction of the prognosis of differentiated thyroid cancer.

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Long-Term Results of Treatment of 283 Patients with Lung and Bone Metastases from Differentiated Thyroid Carcinoma

Cited by 457 publications

References 19 publications

Differentiated Thyroid Carcinoma in Children and Adolescents

Differentiated Thyroid Carcinoma in Children and Adolescents

Animal Models of Bone Metastasis

The role of 18F-fluorodeoxyglucose positron emission tomography in differentiated thyroid cancer before surgery

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