Long-term Results of Treatment of Patients with Non-proliferative Diabetic Retinopathy Angioprotectors

Воробьева, И. В.

doi:10.18008/1816-5095-2017-1-67-77

Cited by 9 publications

(4 citation statements)

References 15 publications

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“…Фролов -концепция и дизайн исследования, ответственность за целостность всех для коррекции липидного статуса, в частности фенофиб рат [44]. Кроме него, поскольку наблюдаются нарушения в свёртывающей системе крови, назначаются антикоагу лянты, так как они способны нормализовывать гемоста зиограмму и содержание специфичных маркёров гипер коагуляции, что в свою очередь приводит к уменьшению количества описанных изменений и, как следствие, сни жению риска стойкой утраты зрительных функций [47]. Так, в национальном руководстве «Офтальмология» для терапии ДР рекомендуют зарубежный препарат су лодексид (Вессел Дуэ Ф), который можно принимать внутрь или в виде внутримышечных инъекций [48].…”

Section: заключениеunclassified

Methods for monitoring the effectiveness of direct-acting anticoagulants in diabetic retinopathy

Vorobyeva,

Biryukov,

Frolov

et al. 2023

Russian Medicine

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The use of anticoagulants is the basis for the treatment of many diseases that cause the development of arterial and venous thrombosis. One such disease is diabetic retinopathy. There is still no consensus on which way to control the effectiveness of these drugs is the best. That is why there is an active search for specific biomarkers that reflect the quality of the treatment. To this end, we analyzed scientific papers that presented the results of various types of laboratory diagnostics aimed at studying the use of various anticoagulants in the treatment of diabetic retinopathy. The analysis of scientific publications was carried out in the information databases PubMed and eLibrary. The review used works containing a description of the main groups of anticoagulants and methods of laboratory control of their use, published over the past 30 years. Review articles, results of experimental studies, monographs, study guides and dissertations were analyzed. It is well known that anticoagulants are divided into two main groups - direct and indirect. In modern clinical practice, mainly direct ones are used. To control their effectiveness, traditional methods for determining the coagulogram are mainly used, but more and more often, the authors resort to a more detailed study of the rheological properties of blood (determination of anti-Xa activity, platelet aggregation using inductors, activity of clotting factors). At the same time, it remains promising to determine their effect on the concentration of pro-inflammatory cytokines and growth factors in the blood serum and lacrimal fluid in diabetic retinopathy. Thus, it can be concluded that there is no consensus on which research methods most accurately reflect the effect of anticoagulants on the hemostatic system and indicators of inflammatory activity in various diseases, in particular in diabetic retinopathy. Therefore, it is necessary to study in more detail what laboratory parameters can change under the influence of these drugs.

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Section: заключениеunclassified

Methods for monitoring the effectiveness of direct-acting anticoagulants in diabetic retinopathy

Vorobyeva,

Biryukov,

Frolov

et al. 2023

Russian Medicine

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“…Interdisciplinary research plays an important role in the diagnosis of diseases. Especially important is the identification of pathogenetic biomarkers in the lacrimal fluid and blood serum [11][12][13]. The leading position is occupied by interdisciplinary research on mathematical modelling in various fields of science [14,15] and programming [16][17][18], including medicine area [19,20].…”

Section: Early Diagnosis Issues Using a Computer Tomograph And Perimmentioning

confidence: 99%

Mathematical modeling in diabetic retinopathy

Vorobyeva

2020

E3S Web Conf.

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The problem of digital medicine in ophthalmology arose in connection with the increase in the incidence of diabetes mellitus in the world. The issue of preventing blindness and early diagnosis in diabetic retinopathy with a forecast of its course using mathematical modeling is especially acute. A system for assessing the prognosis of the risk of developing diabetic retinopathy was created based on interdisciplinary research in three areas: ophthalmology, biochemistry and mathematics. The studies were conducted in ophthalmology with the analysis of the condition of the retina in the macular area using digital ophthalmic equipment (optical coherence tomograph, fundus microperimeter). Biochemical studies consisted in the analysis of tear fluid with the determination of the level of the pathogenetic biomarker VEGF-A and the analysis of blood serum with the determination of the level of glycated hemoglobin HbA1c. Mathematical research consisted in the presentation of digital material in the form of mathematical criteria based on the method of standardizing the indicator under study. The result of the research was a computer program based on the developed mathematical formulas. The program gives the opportunity to automatically enter the data of a specific patient with diabetic retinopathy and give a prognosis of the disease.

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“…With ophtalmoscopy, the changes in the optic nerve head are noticed only at the late stages of glaucoma. Severe retinal edema with hemorrhages and traction syndrome also occurs at the late stages of diabetic retinopathy [11][12][13][14].…”

Section: The State Of the Retina In The Comorbid Pathology Of The Fundusmentioning

confidence: 99%

Assessment of the development of primary open-angle glaucoma and diabetic retinopathy using digital medicine

Vorobyeva

2020

E3S Web Conf.

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The leading place in the structure of blindness and low vision is occupied by two diseases: primary open-angle glaucoma and diabetic retinopathy. The combination of two diseases in one eye gives an even more severe prognosis for vision. Modern diagnostic equipment helps in accurate and early diagnosis of the disease by analyzing digital data of the optic nerve head and macular area of the retina according to the results of an optical coherence tomograph. A mathematical model for predicting the development of diabetic retinopathy and primary open-angle glaucoma according to the proposed mathematical criteria has been developed. The criteria represent the ratio of the integral area of the neuroretinal rim to the integral volume of the neuroretinal rim; the retinal thickness criterion and criterion of the primary open-angle glaucoma and diabetic retinopathy are calculated. A computer program has been developed. The algorithm of the program, which includes windows for entering digital data of the macular zone and parameters of the optic nerve head, is presented. The result of the program is the statement of the risk of developing combined pathology of the fundus in a particular patient.

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Long-term Results of Treatment of Patients with Non-proliferative Diabetic Retinopathy Angioprotectors

Cited by 9 publications

References 15 publications

Methods for monitoring the effectiveness of direct-acting anticoagulants in diabetic retinopathy

Methods for monitoring the effectiveness of direct-acting anticoagulants in diabetic retinopathy

Mathematical modeling in diabetic retinopathy

Assessment of the development of primary open-angle glaucoma and diabetic retinopathy using digital medicine

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