Long-term Results of the UCSF-LBNL Randomized Trial: Charged Particle With Helium Ion Versus Iodine-125 Plaque Therapy for Choroidal and Ciliary Body Melanoma

Mishra, Kavita; Quivey, Jeanne M.; Daftari, Inder K.; Weinberg, Vivian; Cole, T. Boyce; Patel, Kishan; Castro, Joseph R.; Phillips, Theodore L.; Char, Devron H.

doi:10.1016/j.ijrobp.2015.01.029

Cited by 63 publications

(27 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The analysis did not stratify tumors for size and also did not use recent data indicating that PBT produces superior survival compared with enucleation and improved vision preservation compared with plaque brachytherapy . In addition to established data, improved outcomes with PBT against brachytherapy in phase 3 trials are emerging, and future CE analyses correspondingly could be more favorable . The results are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

A systematic review of the cost and cost‐effectiveness studies of proton radiotherapy

Verma

Mishra

Mehta

2016

Cancer

183

145

View full text Add to dashboard Cite

Group of North America for both years of existence (2014)(2015). Eighteen original investigations were analyzed. RESULTS: The costeffectiveness for prostate cancer-the single most common diagnosis currently treated with PBT-was suboptimal. PBT was the most cost-effective option for several pediatric brain tumors. PBT costs for breast cancer were increased but were favorable for appropriately selected patients with left-sided cancers at high risk of cardiac toxicity and compared with brachytherapy for accelerated partial breast irradiation. For non-small cell lung cancer (NSCLC), the greatest cost-effectiveness benefits using PBT were observed for locoregionally advanced-but not early stage-tumors. PBT offered superior cost-effectiveness in selected head/neck cancer patients at higher risk of acute mucosal toxicities. Similar cost-effectiveness was observed for PBT, enucleation, and plaque brachytherapy in patients with uveal melanoma. CONCLUSIONS: With greatly limited amounts of data, PBT offers promising cost-effectiveness for pediatric brain tumors, well-selected breast cancers, locoregionally advanced NSCLC, and high-risk head/neck cancers. Heretofore, it has not been demonstrated that PBT is cost-effective for prostate cancer or early stage NSCLC. Careful patient selection is absolutely critical to assess cost-effectiveness. Together with increasing PBT availability, clinical trial evidence, and ongoing major technological improvements, cost-effectiveness data and conclusions from this analysis could change rapidly. Cancer 2016;122:1483

show abstract

Section: Resultsmentioning

confidence: 99%

A systematic review of the cost and cost‐effectiveness studies of proton radiotherapy

Verma

Mishra

Mehta

2016

Cancer

183

145

View full text Add to dashboard Cite

show abstract

“…Similarly, the recent update of the historical UCSF-LBNL randomized trial of helium vs plaque treatment showed superior results for helium particles with long-term higher LC, eye preservation, and disease-free survival rates at 12 yr follow-up. 5 Eye preservation and vision outcomes are important endpoints as well for radiation modality evaluation. The physical quality of a particle beam allows for reduced peripheral doses to critical structures.…”

Section: Opening Statementmentioning

confidence: 99%

Particle therapy is ideal for the treatment of ocular melanomas

Mishra¹,

Chiu‐Tsao²,

Orton³

2016

Medical Physics

Self Cite

View full text Add to dashboard Cite

“…Proton beam therapy for uveal melanoma continued at the UCSF-LBNL Crocker Lab, with some noteworthy successes [5]. Following the lead in Berkeley, several other hospital-based heavy ion therapy facilities were developed in Japan, Germany, and Italy [6, 7].…”

Section: Historical Flashbackmentioning

confidence: 99%

New Clinical and Research Programs in Particle Beam Radiation Therapy: The University of California San Francisco Perspective

Roach¹,

Schulte²,

Mishra³

et al. 2015

International Journal of Particle Therapy

View full text Add to dashboard Cite

Long-term Results of the UCSF-LBNL Randomized Trial: Charged Particle With Helium Ion Versus Iodine-125 Plaque Therapy for Choroidal and Ciliary Body Melanoma

Cited by 63 publications

References 34 publications

A systematic review of the cost and cost‐effectiveness studies of proton radiotherapy

A systematic review of the cost and cost‐effectiveness studies of proton radiotherapy

Particle therapy is ideal for the treatment of ocular melanomas

New Clinical and Research Programs in Particle Beam Radiation Therapy: The University of California San Francisco Perspective

Contact Info

Product

Resources

About