Long-term results of severe acute pancreatitis management

Exocrine Pancreatic Insufficiency Following Acute Pancreatitis: Systematic Review and Meta-Analysis

“…The study designs are summarized in Table 1 . Thirty-seven studies were published in English, two [ 27 , 29 ] in Spanish, one [ 41 ] in Italian and one [ 59 ] in Russian. There were two RCTs [ 30 , 55 ] for PERT versus placebo and one for the endoscopic versus surgical step-up approach [ 64 ].…”

“…For ten inpatient studies, the pooled median age was 51 years (males, 59%); etiology was 70% gallstones, 17% alcohol and 13% other causes; six studies were restricted to first AP episodes [ 30 , 31 , 40 , 44 , 48 , 49 ], while four [ 25 , 27 , 29 , 55 ] did not report. For the 39 follow-up studies, the pooled median age was 51 years (males, 63%); etiology was 55% gallstone, 28% alcohol and 17% other causes; 16 studies were restricted to first AP episodes [ 30 – 34 , 39 , 40 , 43 – 46 , 48 , 50 , 53 , 57 , 60 ], while 5 [ 28 , 35 , 38 , 56 , 62 ] were not so restricted, and the remaining 18 [ 24 – 27 , 29 , 36 , 37 , 41 , 42 , 47 , 51 , 52 , 54 , 58 , 59 , 61 , 63 , 64 ] did not report.…”

“…In the 39 follow-up studies, body mass index, alcohol history, cigarette smoking and symptoms of EPI were rarely recorded (data not shown). Nine studies [ 24 , 38 , 48 , 51 , 52 , 54 , 60 , 61 , 64 ] had a minor proportion of pre-existing DM (1.3–18%), 8 [ 40 , 46 , 47 , 50 , 53 , 57 , 58 , 62 ] had none, and the remaining 22 [ 25 – 37 , 39 , 41 – 45 , 56 , 59 , 63 ] did not report; 22 [ 26 , 28 , 32 , 33 , 37 , 38 , 42 , 44 – 47 , 50 – 54 , 57 – 59 , 61 , 62 ] had a proportion of patients who had undergone pancreatic interventions; 10 [ 25 , 30 , 31 , 34 , 39 – 41 , 43 , 60 , 63 ] reported no pancreatic interventions, and the remaining 7 [ 24 , 27 , 29 , 35 , 36 , 48 , 56 ] did not report.…”

“…In eight studies [ 40 , 46 , 53 , 54 , 56 , 59 , 61 , 62 ] that reported the severity of EPI and used the FE-1 test, the pooled prevalence of mild to moderately severe EPI was 16% (CI 10–24%) (Supplementary Figure 6A) and of severe EPI was 11% (CI 6–17% (Supplementary Figure 6B).…”

Pharmacological correction of immune and metabolic disorders in acute biliary pancreatitis of varying severity

“…Факторы агрессии четвертого порядкацитокины, тканевые ферменты, метаболиты, измененные в результате патологического процесса различной природы. Очевидно, что факторы агрессии третьего и четвертого порядка в основном являются продуктами клеток иммунной системы [5][6][7][8].…”