Long-term Results of RTOG 0236: A Phase II Trial of Stereotactic Body Radiation Therapy (SBRT) in the Treatment of Patients with Medically Inoperable Stage I Non-Small Cell Lung Cancer

Timmerman, Robert; Hu, Chen; Michalski, Jeff M.; Straube, William L.; Galvin, James M.; Johnstone, David; Bradley, Jeffrey D.; Barriger, R. Bryan; Bezjak, Andrea; Videtic, Gregory M.M.; Nedzi, Lucien A.; Werner‐Wasik, Maria; Chen, Y.; Komaki, Ritsuko; Choy, Hak

doi:10.1016/j.ijrobp.2014.05.135

Cited by 177 publications

(142 citation statements)

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“…11,12 The second most treated site was spine, which has low/moderate level of evidence publications and some available protocols. 13,14 Prostate and liver neoplasms were less frequent; however, there are also many studies reporting the use of SBRT in these sites and feasible protocols available. 15,16 Although our results have shown 25.7% of treatments without a formal protocol statement, a protocol was indeed followed, even though not reported, respecting the dose constraints in healthy surrounding tissue and planning report, in the treatment of all patients.…”

Section: Resultsmentioning

confidence: 99%

“…Lung neoplasms were treated regarding to tumor location (central and peripheral lesion) and mainly two Radiation Therapy Oncology Group (RTOG) protocols were followed -RTOG 0236 and RTOG 0813. 14,17 Spinal metastatic lesions half of the times were formally managed according to the RTOG 0631 protocol and target definition was mostly based on an international consensus. 13,18 This illustrates the positive impact that international protocols and recommendations have in our setting.…”

Section: Resultsmentioning

confidence: 99%

“…no critical organs nearby) and, specially, when the target moves (less dose blurring and leaf motion interplay effects compared to intensity modulated techniques). Therefore, 3DCRT is the preferred choice for the majority of lung (RTOG protocols 0236 and 0813 do not recommend highly modulated fields) 14,23 and liver cases. IMRT was used in few situations and was rapidly substituted by VMAT as soon as this technology turned available in the institution, due to the shorter treatment time and more comfort for the patients.…”

Section: Resultsmentioning

confidence: 99%

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Emerging radiotherapy technology in a developing country: A single Brazilian institution assessment of stereotactic body radiotherapy application

Moraes

Bonifacio

Neves-Junior

et al. 2016

Rev. Assoc. Med. Bras.

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Objective: To provide a quantitative profile of the indications and use of stereotactic body radiotherapy (SBRT) in a developing country oncology-based institution. In addition, to describe the patients' and treatment characteristics, and to provide a temporal analysis. Method: SBRT patients treated from 2007 to 2015 were retrospectively evaluated by two independently investigators. Data were stratified and compared in two periods: first experience (FE) (May 2007 to April 2011), and following experience (FollowE) (May 2011 to April 2015). The following parameters were compared between the groups: total number of treated patients and lesions, treatment site, additional image fusion used, formal protocol adoption, and SBRT planning technique. Results: One hundred and seventy-six (176) patients with 191 lesions were treated: 34 (18%) lesions in the FE and 157 (82%) lesions in FollowE. The majority of lesions were metastases (60.3%), and lung (60.2%) was the most common treatment site, followed by spine (31%), and others (8.8%). An average of 1.4 (±0.6) additional imaging exams for delineation was performed. Conformal 3D radiotherapy planning technique was used in 64.4%, and intensity modulated radiotherapy (IMRT) or volumetric-modulated arc therapy (VMAT) in the remaining 35.6% (p=0.0001). Higher rates of curative treatments were observed in FE, as well as more lung lesions, patients ≥ 70 years, 3D conformal, number of additional images and ECOG 0, and all presented p<0.05. The global rate of protocol statement was 79%, lung treatment being the most stated. Conclusion: SBRT application is rapidly increasing in our setting. Treatment sites and planning techniques are becoming more diversified and complex.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Emerging radiotherapy technology in a developing country: A single Brazilian institution assessment of stereotactic body radiotherapy application

Moraes

Bonifacio

Neves-Junior

et al. 2016

Rev. Assoc. Med. Bras.

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“…V 105 (high dose) was 105% of prescribed dose delivered to volume of body minus PTV, low dose as the falloff gradient was defined as dose to volume of body minus 2 cm expansion of PTV according to RTOG0236 protocol [1].…”

Section: Methodsmentioning

confidence: 99%

Dosimetric Comparisons of Lung SBRT with Multiple Metastases by Two Advanced Planning Systems

Zhang¹,

Chen²,

Qin³

et al. 2014

IJMPCERO

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Purpose: To evaluate planning quality of Stereotactic body Radiotherapy (SBRT) with multiple lungmetastases generated by the Pinnacle and Tomotherapy planning systems, respectively. Methods and Materials: Nine randomly selected patients diagnosed with non-small cell lung carcinoma with multiple lesions were planned with Philips Pinnacle (version 9.2, Fitchburg, WI) and Tomotherapy (version 4.2, Madison, WI), respectively. Both coplanar and non-coplanar IMRT plans were generated on Pinnacle system. A total dose of 60 Gy was prescribed to cover 95% of Planning Target 253while sparing more critical structures in the multiple lung lesions study. Non-coplanar IMRT plans also have better tumor coverage with lower dose to critical organs such as lungs, liver, chest wall and cord compare to coplanar plans. Compared to the coplanar IMRT beam plans, Tomotherapy tends to have a relatively higher low dose volume in lungs such as V 5 which needs more attention for toxicity analysis.

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“…Overall survival was 40% at 5 years. 14 Results from SBRT studies from other institutions are wellsummarized in a systematic review and meta-analysis by Grutters et al, 9 who used a random effects analysis to evaluate OS and disease-specific survival for patients with lung cancer treated with conventional radiotherapy (CRT), SBRT, or particle therapy (proton therapy and carbon-ion therapy). 9 The meta-analysis found that, when corrected for differences in percentages of inoperable patients, there was no statistical difference in 2-year overall survival for patients treated with SBRT, proton, or carbon-ion therapy.…”

Section: Outcomes With Sbrt: Key Studiesmentioning

confidence: 99%

Stereotactic radiotherapy for early lung cancer: Evidence-based approach and future directions

Chehade

Palma

2015

Reports of Practical Oncology & Radiotherapy

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Long-term Results of RTOG 0236: A Phase II Trial of Stereotactic Body Radiation Therapy (SBRT) in the Treatment of Patients with Medically Inoperable Stage I Non-Small Cell Lung Cancer

Cited by 177 publications

References 0 publications

Emerging radiotherapy technology in a developing country: A single Brazilian institution assessment of stereotactic body radiotherapy application

Emerging radiotherapy technology in a developing country: A single Brazilian institution assessment of stereotactic body radiotherapy application

Dosimetric Comparisons of Lung SBRT with Multiple Metastases by Two Advanced Planning Systems

Stereotactic radiotherapy for early lung cancer: Evidence-based approach and future directions

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