Long term results of primary posterior chamber intraocular lens implantation for congenital cataract in the first year of life

Gouws, Pieter; Hussin, Hussin Mangosha; Markham, R.H.

doi:10.1136/bjo.2006.094656

Cited by 43 publications

(34 citation statements)

References 12 publications

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“…old [2][3][4][5]. It has been reported that a younger age at the time of surgery, has been positively correlated with the development of postoperative complications requiring secondary surgery.…”

Section: Introductionmentioning

confidence: 97%

Visual results and complications of primary intraocular lens implantation in infants aged 6 to 12 months

Luo

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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Primary IOL implantation was safe and effective for infantile cataract surgery. Total or unilateral cataract, nystagmus or strabismus, and inadequate amblyopic therapy were predictors of poor BCVA. Significant myopic shifts occurred especially in infants in the first year of surgery. The pseudophakic eye had a similar growth rate, as measured by axial length, to that of the fellow normal eye, in unilateral cases.

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Section: Introductionmentioning

confidence: 97%

Visual results and complications of primary intraocular lens implantation in infants aged 6 to 12 months

Luo

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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“…Gouws et al [14] reported on 18 infants undergoing surgery at less than 1 year of age with a mean follow-up of 95 months: best outcomes were in the bilateral group where 50 per cent of eyes achieved 6/18 or better, with a best acuity of 6/9. Acuities were worse in the unilateral group where only 38 per cent achieved 6/60 or better, with a best acuity of 6/24.…”

Section: Clinical Aspects Of Congenital or Paediatric Cataract (A) Comentioning

confidence: 99%

Clinical and experimental advances in congenital and paediatric cataracts

Churchill

Graw

2011

Phil. Trans. R. Soc. B

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Cataracts (opacities of the lens) are frequent in the elderly, but rare in paediatric practice. Congenital cataracts (in industrialized countries) are mainly caused by mutations affecting lens development. Much of our knowledge about the underlying mechanisms of cataractogenesis has come from the genetic analysis of affected families: there are contributions from genes coding for transcription factors (such as FoxE3, Maf, Pitx3) and structural proteins such as crystallins or connexins. In addition, there are contributions from enzymes affecting sugar pathways (particularly the galactose pathway) and from a quite unexpected area: axon guidance molecules like ephrins and their receptors. Cataractous mouse lenses can be identified easily by visual inspection, and a remarkable number of mutant lines have now been characterized. Generally, most of the mouse mutants show a similar phenotype to their human counterparts; however, there are some remarkable differences. It should be noted that many mutations affect genes that are expressed not only in the lens, but also in tissues and organs outside the eye. There is increasing evidence for pleiotropic effects of these genes, and increasing consideration that cataracts may act as early and readily detectable biomarkers for a number of systemic syndromes.

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“…Primary IOL implantation has become the treatment of choice in older children, with medium- to longer-term outcome data becoming available,2 3 20 and there is good biocompatibility evidence for IOL material implantation in young eyes 21. Short-term visual rehabilitation following IOL implantation in early childhood is at least comparable with that with contact lens correction of surgical aphakia,5 7 22 23 but there is uncertainty about both the long-term benefits and the risks of primary IOL implantation in children aged under 2 years, with regards to the predictability of refractive outcomes with different power equations, postoperative complication rates and the need for further surgery 7 23 24 25. The Infant Aphakia Treatment Study, currently under way in North America, is investigating outcomes in a defined cohort of infants under 6 months old with unilateral cataract6 following standardised cataract surgery with and without primary IOL implantation.…”

Section: Discussionmentioning

confidence: 99%

“…While primary IOL implantation is being increasingly undertaken in children in the first 2 years of life,3 4 the long-term benefits and the factors associated with positive and negative outcomes are unclear 1 2 5 6 7 8 9…”

mentioning

confidence: 99%

Cataract surgery and primary intraocular lens implantation in children <=2 years old in the UK and Ireland: finding of national surveys

Solebo

Russell‐Eggitt

Nischal

et al. 2009

British Journal of Ophthalmology

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Primary IOL implantation in children < or =2 has been widely adopted in the UK and Ireland. There is concordance of practice with regards to surgical technique and choice of IOL model. However, there is some variation in eligibility criteria for primary IOLs: this may reflect a lack of consensus on which children are most likely to benefit. Thus, there is a need for systematic studies of the outcomes of primary IOL implantation in younger children.

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Long term results of primary posterior chamber intraocular lens implantation for congenital cataract in the first year of life

Cited by 43 publications

References 12 publications

Visual results and complications of primary intraocular lens implantation in infants aged 6 to 12 months

Visual results and complications of primary intraocular lens implantation in infants aged 6 to 12 months

Clinical and experimental advances in congenital and paediatric cataracts

Cataract surgery and primary intraocular lens implantation in children <=2 years old in the UK and Ireland: finding of national surveys

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