Long‐term results of octreotide‐therapy in severe dumping syndrome

Vecht, J. van der; Lamers, C. B. H. W.; Masclee, Ad

doi:10.1046/j.1365-2265.1999.00819.x

Cited by 57 publications

(35 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Octreotide alleviates both early and late dumping symptoms through inhibition of hormones such as VIP, serotonin, and insulin. It also delays gastric emptying time and inhibits splanchnic vasodilation [45,46]. Octreotide is administered subcutaneously 5 min before each meal with a starting dose of 50 mcg, although titration from 25 to 100 mcg may be required.…”

Section: Pharmacologic Treatmentmentioning

confidence: 99%

Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment

2015

View full text Add to dashboard Cite

Gastric surgery has long been known to be a cause of dumping syndrome (DS). However, the increasing incidence of gastric bypass surgery, as well as reports of DS unrelated to previous gastric surgeries, has increased the importance of understanding DS in recent years. DS is due to the gastrointestinal response to voluminous and hyperosmolar chyme that is rapidly expelled from the stomach into the small intestine. This response involves neural and hormonal mechanisms. This review encompasses the symptoms, diagnosis, and treatment approaches of DS and also focuses on the current research status of the pathophysiology of DS.

show abstract

Section: Pharmacologic Treatmentmentioning

confidence: 99%

Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment

2015

View full text Add to dashboard Cite

show abstract

“…If these measures fail, subcutaneous injections of somatostatin (50-100 g) two or three times a day 30 min before meals, or long acting somatostatin analogs, may reduce symptoms by limiting the secretion of insulin and numerous intestinal peptides and by delaying gastric emptying. These treatments have a spectacular effect, with nearly 100% short-term efficacy [41] but the high cost limits long-term use.…”

Section: Managementmentioning

confidence: 99%

Functional disorders and quality of life after esophagectomy and gastric tube reconstruction for cancer

Poghosyan

Gaujoux

Chirica

et al. 2011

Journal of Visceral Surgery

View full text Add to dashboard Cite

Functional disorders such as delayed gastric emptying, dumping syndrome or duodeno-gastro-esophageal reflux occur in half of the patients who undergo esophagectomy and gastric tube reconstruction for cancer. The potential role for pyloroplasty in the prevention of functional disorders is still debated. Antireflux fundoplication during esophagectomy can apparently reduce the reflux but at the cost of increasing the complexity of the operation; it is not widely used. The treatment of functional disorders arising after esophagectomy and gastroplasty for cancer is based mainly on dietary measures. Proton pump inhibitors have well documented efficiency and should be given routinely to prevent reflux complications. Erythromycin may prevent delayed gastric emptying, but it should be used with caution in patients with cardiovascular disorders. In the event of anastomotic stricture, endoscopic dilatation is usually efficient. Problems related to gastrointestinal functional disorders after esophageal resection and gastric tube reconstruction do not significantly impair long-term quality of life, which is mainly influenced by tumor recurrence.

show abstract

“…Studies using acarbose (reducing carbohydrate absorption rate) (17) and somatostatin analogues (inhibiting excessive insulin responses) (18) have moderate effects. Partial or total pancreatectomy are currently not considered appropriate since symptoms do not always improve or may reoccur, even if beta cell mass is decreased (19)(20)(21)(22) .…”

Section: Introductionmentioning

confidence: 99%

More symptoms but similar blood glucose curve after oral carbohydrate provocation in patients with a history of hypoglycemia-like symptoms compared to asymptomatic patients after Roux-en-Y gastric bypass

Laurenius

Werling

Roux

et al. 2014

Surgery for Obesity and Related Diseases

View full text Add to dashboard Cite

Long‐term results of octreotide‐therapy in severe dumping syndrome

Abstract: Self-administration of octreotide proves an effective symptomatic treatment of severe dumping, even on the long-term. Its use is frequently limited by the occurrence of side-effects.

Cited by 57 publications

References 27 publications

Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment

Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment

Functional disorders and quality of life after esophagectomy and gastric tube reconstruction for cancer

More symptoms but similar blood glucose curve after oral carbohydrate provocation in patients with a history of hypoglycemia-like symptoms compared to asymptomatic patients after Roux-en-Y gastric bypass

Contact Info

Product

Resources

About