Long-Term Results of Nephron Sparing Surgery for Localized Renal Cell Carcinoma: 10-Year Followup

Fergany, Amr; Hafez, Khaled S.; Novick, Andrew C.

doi:10.1016/s0022-5347(05)67896-2

Cited by 959 publications

(469 citation statements)

References 10 publications

Supporting

Mentioning

431

Contrasting

Unclassified

Order By: Relevance

“…Median intervals between postoperative GFR estimations were similar for both groups (radical nephrectomy, 4 months [IQR 1-6] vs partial nephrectomy, 6 months [2][3][4][5][6][7]). Despite having normal preoperative concentrations of serum creatinine, 171 (26%) patients had estimated GFRs lower than 60 mL/min per 1·73 m 2 , and 15 (2%) had estimated GFRs lower than 45 mL/ min/1·73 m 2 (table 1).…”

Section: Resultsmentioning

confidence: 97%

“…2 Because of the small size and early stage of these tumours, surgeons are able to do partial nephrectomies without compromising safety and oncological efficacy. 3,4 In tertiary-care centres in the USA, partial nephrectomy now accounts for 30-65% of all surgical procedures for renal cortical tumours. 5-7 However, this trend does not represent current US surgical practice for renal cortical tumours.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study

Huang

Levey

Serio

et al. 2006

The Lancet Oncology

1,463

887

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study

Huang

Levey

Serio

et al. 2006

The Lancet Oncology

1,463

887

View full text Add to dashboard Cite

show abstract

“…Until this time, these data provide insight into current clinical practice. Despite the fact that partial nephrectomy offers equivalent local tumor control to its radical counterpart, 27,28 national trends illustrate that the uptake of nephron-sparing surgery for small ( 4 cm) renal masses has been slow. 29 These utilization trends are troubling when considered in the context of recent findings that show radical nephrectomy to be a significant risk factor for the development of chronic kidney disease.…”

Section: Discussionmentioning

confidence: 99%

Five‐year survival after surgical treatment for kidney cancer

Hollingsworth

Miller

Daignault

et al. 2007

Cancer

255

133

View full text Add to dashboard Cite

BACKGROUND.Kidney cancer's rising incidence is largely attributable to the increased detection of small renal masses. Although surgery rates have paralleled this incidence trend, mortality continues to rise, calling into question the necessity of surgery for all patients with renal masses. Using a population‐based cohort, a competing risk analysis was performed to estimate patient survival after surgery for kidney cancer, as a function of patient age and tumor size at diagnosis.METHODS.With data from the Surveillance, Epidemiology, and End Results Program (1983–2002), a cohort was assembled of 26,618 patients with surgically treated, local‐regional kidney cancer. Patients were sorted into 20 age‐tumor size categories and the numbers of patients that were alive, dead from kidney cancer, and dead from other causes were tabulated. Poisson regression models were fitted to obtain estimates of cancer‐specific and competing‐cause mortality.RESULTS.Age‐specific kidney cancer mortality was stable across all size strata but varied inversely with tumor size. Patients with the smallest tumors enjoyed the lowest cancer‐specific mortality (5% for masses ≤4 cm). Competing‐cause mortality rose with increasing patient age. The estimated 5‐year competing‐cause mortality for elderly subjects (≥70 years) was 28.2% (95% confidence interval [CI]: 25.9%–30.8%), irrespective of tumor size.CONCLUSIONS.Despite surgical therapy, competing‐cause mortality for patients with renal masses rises with increasing patient age. After 5 years, one‐third of elderly patients (≥70 years) will die from other causes, suggesting the need for prospective studies to evaluate the role of active surveillance as an initial therapeutic approach for some small renal masses. Cancer 2007. © 2007 American Cancer Society.

show abstract

“…In appropriately selected patients, PN is associated with equivalent 10-year disease-free survival and local recurrence rates when compared to RN. 1,32,33 Additionally, PN is associated with better long-term renal function and may play a critical role in improving subsequent outcomes related to cardiac morbidity and overall survival. [2][3][4] Although well-established in the treatment of T1a renal tumours, the role of PN for the treatment of larger masses is still being evaluated.…”

Section: Partial Nephrectomymentioning

confidence: 99%

886 Partial nephrectomy for the treatment of renal cell carcinoma and the risk of end stage renal disease

Yap¹,

Alibhai²,

Tomlinson³

et al. 2013

European Urology Supplements

View full text Add to dashboard Cite

The surgical management of renal masses involves either radical nephrectomy (RN) or partial nephrectomy (PN). PN has been associated with better long-term renal function, and has also been linked to improved cardiac morbidity and overall survival. However, the relationship between treatment choice and definitive outcomes of chronic kidney disease (CKD) are lacking. Our aim was to examine whether PN is associated with a lower risk of end-stage renal disease (ESRD) requiring renal replacement therapy.We performed a population-based, retrospective cohort study with data from linked administrative databases in the province of Ontario, Canada. We included individuals with pathologically confirmed renal cell carcinoma (RCC) diagnosed between 1995 and 2010. Cox proportional hazards (PH) models, propensity score models, and competing risks models were used to assess the impact of treatment choice. PN compared to RN reduces the risk of ESRD requiring renal replacement therapy in a modern cohort of patients (2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010). PN is associated with a lower risk of new-onset CKD, lower risk of cardiac morbidity, and improved overall survival. We provide further evidence for the benefit of PN compared to RN, particularly related to definitive outcomes of renal failure.iii ACKNOWLEDGEMENTS

show abstract

Long-Term Results of Nephron Sparing Surgery for Localized Renal Cell Carcinoma: 10-Year Followup

Abstract: Partial nephrectomy is effective for localized renal cell carcinoma, providing long-term tumor control with preservation of renal function.

Cited by 959 publications

References 10 publications

Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study

Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study

Five‐year survival after surgical treatment for kidney cancer

886 Partial nephrectomy for the treatment of renal cell carcinoma and the risk of end stage renal disease

Contact Info

Product

Resources

About