Long-Term Results of Mandibular Distraction Osteogenesis with a Resorbable Device in Infants with Robin Sequence

Paes, Emma C.; Bittermann, Gerhard Koendert Pieter; Bittermann, Dirk; Muradin, M.S.M.; Hogezand, Rose Van; Etty, E.J.; Molen, Aebele B. Mink van der; Kon, Moshe; Breugem, Corstiaan C.

doi:10.1097/01.prs.0000475769.06773.86

Cited by 33 publications

(29 citation statements)

References 41 publications

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“…Mandibular distraction osteogenesis predictably advances the tongue base by correcting the primary morphologic deficiency (Zellner et al, 2017) and is generally safe and well tolerated, although infrequent complications include surgical site infection, hardware failure, and facial nerve injury (Murage et al, 2014). Long-term disruptions to the primary and permanent dentition have also been reported (Paes et al, 2016; Peacock et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Neonatal Mandibular Distraction Does Not Increase Inpatient Complications

Lee

Eisig

Chuang

et al. 2019

The Cleft Palate-Craniofacial Journal

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Objective: The purpose of this study was to determine whether performing mandibular distraction osteogenesis (MDO) during the neonatal period increased inpatient complications as measured through health-care burden. Materials and Methods: This was a retrospective cohort study of the Kids’ Inpatient Database from 2000 to 2011. Infants receiving MDO prior to 12 months of age were included. The primary study predictor was distraction age, classified as either neonatal or non-neonatal. Secondary predictors were patient demographics, hospitalization characteristics, diagnoses, and procedures. The outcomes were the number of procedures performed, postoperative length of stay (pLOS), hospital charges, and the discharge transfer rate. Outcomes were compared between the primary predictors using χ2 and independent 2-sample t tests. Multiple linear and logistic regression models were created using clinically relevant predictors to assess the independent effect of neonatal age on each outcome. Results: The study sample contained 102 patients, of who 50 (49.0%) were distracted in the neonatal period. Neonatal MDO patients were more likely to have a cleft palate (86.0% vs 55.8%; P < .001) and present with feeding difficulties (38.0% vs 19.2%; P = .036) that were treated through total parenteral nutrition (26.0% vs 9.6%; P = .030) but otherwise did not have significantly different characteristics compared to non-neonatal patients. The multiple regression models confirmed that neonatal age did not influence any of the study outcomes, although other secondary predictors were found to influence the pLOS, hospital charges, and number of inpatient procedures. Conclusions: Neonatal MDO was not associated with increased complications. At experienced centers, neonatal status should not be considered a contraindication to treatment.

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Section: Introductionmentioning

confidence: 99%

Neonatal Mandibular Distraction Does Not Increase Inpatient Complications

Lee

Eisig

Chuang

et al. 2019

The Cleft Palate-Craniofacial Journal

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“…Early complications include infection, hardware malfunction, bony malunion or nonunion, or inferior alveolar or marginal mandibular nerve damage (Mofid et al, 2001;Master et al, 2010). Late and long-term complications have yet to be completely elucidated, but include tooth bud injury and abnormality (Master et al 2010;Paes et al, 2013), malocclusion and temporomandibular joint malfunction (Reina-Romo et al, 2010;Murage et al, 2014;Verlinden et al, 2015;Paes et al, 2016;Scott 2016;Zimmerman et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Biomechanical and morphological analysis of Pierre Robin sequence mandible: Finite element and morphometric study

Humphries

Reid

Ross

et al. 2020

The Anatomical Record

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“…Although overtreating may sound like a safer option to potentially avoid deaths and life-threating complications, surgeries come with complications as well. In particular, MDO, despite having a high success rate, is associated with postoperative complications including infection, inferior alveolar and marginal mandibular nerve damage, mandibular growth disturbances, tooth bud damage, relapse of distracted bone, temporomandibular joint ankyloses, and death; hence, a narrower threshold is needed for surgical intervention based on physiologic effects of airway obstruction (Allen, 2005; da Silva Freitas et al, 2008; Tibesar et al, 2010; Paes et al, 2013; Lam et al, 2014; Murage et al, 2014; Tsang et al, 2015; Verlinden et al, 2015; Paes et al, 2016). We currently advocate for definitive airway placement if the patient is in severe respiratory distress requiring endotracheal intubation.…”

Section: Discussionmentioning

confidence: 99%