Long-term results of intratympanic prednisolone injection in patients with idiopathic sudden sensorineural hearing loss

Abstract

The comparison of audiometric data at study entry, at 10 days, and at 1 year after the treatment showed a statistically significant improvement of the mean pure tone audiometry. The evaluation of the hearing outcomes demonstrated a statistically significant improvement, with similar success rates when evaluated 10 days and 1 year after the treatment. Comparing the hearing outcomes at 1 year with the results at 10 days, no significant difference was detected between these two time points.

Tinnitus in Temporomandibular Joint Disorders: Is it a Specific Somatosensory Tinnitus Subtype?

“…Studies in animal models have already highlighted the neural pathways through which the trigeminal afferents may interact at the level of the central nervous system 21,22 . The trigeminal input, through the Gasser ganglio and the trigeminal nuclear complex, reaches the dorsal cochlear nucleus (DCN) 23 , and may affect the activity of the central sound 24 , especially in situations of concomitant cochlear damage. Moreover, in patients suffering from tinnitus, it has been shown that the intensity of the symptom can be modulated by a somatosensory stimulation (electrical stimulation of the median nerve at the wrist) 24 , an experience that is interpreted as non-specific activation of nerve structures in the process of extra-lemniscal tinnitus genesis 25 .…”

Effect of comorbid diabetes and hypercholesterolemia on the prognosis of idiopathic sudden sensorineural hearing loss

“…Gundogan et al, for example, advocated a 1‐month follow‐up, Battaglia et al a 2‐month follow‐up, Filipo et al a specific (1‐year) long‐term follow‐up, and Fushiki et al a nonspecific long‐term follow‐up . We chose a 2‐month follow‐up time because < 8% of patients are expected to experience further hearing improvement after 2 months . However, improvement may occur in the chronic phase of ISSNHL after therapy for comorbid Hch …”

“…The follow-up period after the initiation of treatment for ISSNHL varied in other reports. Gundogan et al, 38 for example, advocated a 1-month follow-up, Battaglia et al 39 a 2-month follow-up, Filipo et al 40 a specific (1-year) long-term follow-up, and Fushiki et al 41 a nonspecific long-term follow-up. 42 We chose a 2-month follow-up time because < 8% of patients are expected to experience further hearing improvement after 2 months.…”

“…42 We chose a 2-month follow-up time because < 8% of patients are expected to experience further hearing improvement after 2 months. 40 However, improvement may occur in the chronic phase of ISSNHL after therapy for comorbid Hch. 35…”

Concurrent hyperbaric oxygen therapy and intratympanic steroid application as salvage therapy after severe sudden sensorineural hearing loss

“…In combination with HBOT, the overall success rate of ITS was superior when compared to i.v. steroid application . However, HBOT in addition to application of a vitamin cocktail and dexamethasone, did not improve chronic ISSNHL in another study .…”