Long-Term Results of Hepatic Resection Combined with Intraoperative Local Ablation Therapy for Patients with Multinodular Hepatocellular Carcinomas

Itoh, Shinji; Morita, Kazutoyo; Ueda, Shinichiro; Sugimachi, Keizō; Yamashita, Yo Ichi; Gion, Tomonobu; Fukuzawa, Kengo; Wakasugi, Kenzo; Taketomi, Akinobu; Maehara, Yoshihiko

doi:10.1245/s10434-009-0721-0

Cited by 44 publications

(29 citation statements)

References 38 publications

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“…Hepatic resection is a safe and effective treatment in patients with HCC and well preserved liver function. However, the proportion of patients who develop intrahepatic recurrence remains high.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of inflammatory biomarkers in hepatocellular carcinoma following hepatic resection

et al. 2019

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Background Cancer‐related inflammation has been correlated with cancer prognosis. This study evaluated inflammatory biomarkers, including neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR) and lymphocyte‐to‐monocyte ratio (LMR), programmed death ligand (PD‐L) 1 expression, and tumour microenvironment in relation to prognosis and clinicopathological features of patients with hepatocellular carcinoma (HCC) undergoing curative hepatic resection. Methods Patients who had liver resection for HCC in 2000–2011 were analysed. Univariable and multivariable analyses were conducted for overall (OS) and recurrence‐free (RFS) survival. Immunohistochemical analyses of PD‐L1, CD8 and CD68 expression were performed. HCC cell lines were evaluated for PD‐L1 expression. A subgroup analysis was conducted to determine patient features, survival and the tumour microenvironment. Results were validated in a cohort of patients with HCC treated surgically in 2012–2016. Results Some 281 patients who underwent hepatic resection for HCC were included. Multivariable analysis showed that low LMR was an independent prognostic factor of OS (hazard ratio (HR) 1·59, 95 per cent c.i. 1·00 to 2·41; P = 0·045) and RFS (HR 1·47, 1·05 to 2·04; P = 0·022) after resection. Low preoperative LMR values were correlated with higher α‐fetoprotein values (P < 0·001), larger tumour size (P < 0·001), and high rates of poor differentiation (P = 0·035) and liver cirrhosis (P = 0·008). LMR was significantly lower in PD‐L1‐positive patients than in those with PD‐L1 negativity (P < 0·001). Results were confirmed in the validation cohort. PD‐L1 expression was upregulated in HCC cell lines treated with interferon‐γ and co‐cultured with THP‐1 monocyte cells. Conclusion LMR is an independent predictor of survival after hepatic resection in patients with HCC. Modulation of the immune checkpoint pathway in the tumour microenvironment is associated with a low LMR.

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Section: Introductionmentioning

confidence: 99%

Prognostic significance of inflammatory biomarkers in hepatocellular carcinoma following hepatic resection

et al. 2019

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“…Hepatocellular carcinoma (HCC) is the most prevalent epithelial cancer of the liver, and one of the most common causes of cancer‐related death in many countries, especially in Japan . Hepatic resection has been established as a safe and effective treatment for HCC . There is a high prevalence of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in the general population of Japan; however, the proportion of HCC cases negative for hepatitis B surface antigen (HBsAg) and hepatitis C virus antibody (HCVAb), termed non‐B, non‐C HCC (NBNC‐HCC), is currently increasing …”

Section: Introductionmentioning

confidence: 99%

Associations between antibody to hepatitis B core antigen positivity and outcomes in hepatocellular carcinoma patients undergoing hepatic resection

Itoh

Yoshizumi

Tomino

et al. 2017

Hepatology Research

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“…1,2 Hepatic resection has been established as a safe and effective treatment for HCC. 3,4 Although surgical techniques and postoperative management have recently improved, 5,6 postoperative morbidity in patients with HCC remains elevated. 7,8 Liver dysfunction is the major cause of postoperative morbidity and mortality after hepatic resection.…”

Section: Introductionmentioning

confidence: 99%

Functional remnant liver assessment predicts liver‐related morbidity after hepatic resection in patients with hepatocellular carcinoma

Itoh

Yoshizumi

Shirabe

et al. 2016

Hepatology Research

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Long-Term Results of Hepatic Resection Combined with Intraoperative Local Ablation Therapy for Patients with Multinodular Hepatocellular Carcinomas

Abstract: Hepatic resection combined with intraoperative local ablation therapy is effective for multinodular HCCs. DCP >300 mAU/ml was a significant prognostic factor of long-term overall survival.

Cited by 44 publications

References 38 publications

Prognostic significance of inflammatory biomarkers in hepatocellular carcinoma following hepatic resection

Prognostic significance of inflammatory biomarkers in hepatocellular carcinoma following hepatic resection

Associations between antibody to hepatitis B core antigen positivity and outcomes in hepatocellular carcinoma patients undergoing hepatic resection

Functional remnant liver assessment predicts liver‐related morbidity after hepatic resection in patients with hepatocellular carcinoma

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