Long-term Results of Bariatric Surgery for Non-alcoholic Fatty Liver Disease/Non-alcoholic Steatohepatitis Treatment in Morbidly Obese Japanese Patients

Uehara, Daisuke; Seki, Yosuke; Kakizaki, Satoru; Horiguchi, Norio; Tojima, Hiroki; Yamazaki, Yuichi; Sato, Ken; Yamada, Masanobu; Uraoka, Toshio; Kasama, Kazunori

doi:10.1007/s11695-018-03641-2

Cited by 14 publications

(10 citation statements)

References 18 publications

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“…According to a recent systematic review, resolution of hepatic steatosis was demonstrated in >75% of patients, and improvements in ballooning and lobular inflammation were consistently observed 146 . In addition, a long‐term follow‐up study of 102 obese Japanese patients undergoing bariatric surgery demonstrated that liver fat accumulation and visceral fat areas were significantly improved at 1 year after surgery, and the decrease in BMI, body fat percentage, and basal metabolic rate prolonged for at least 5 years 147 . In 37 Asian patients receiving annual TE following bariatric surgery, the mean LSM reduced significantly from baseline values of 9.8‐6.8 kPa at 5 years after operation 148 .…”

Section: Assessment and Management Of Nafldmentioning

confidence: 99%

Changing clinical management of NAFLD in Asia

Nakatsuka

Tateishi

Koike

2021

Liver International

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Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease, affecting approximately 25% of the world's population. Recently, because of the sedentary lifestyle and overnutrition resulting from urbanisation, the burden of NAFLD has rapidly increased in many Asian countries. Currently, the prevalence of NAFLD in Asia is approximately 30%, as is the case in many Western countries. In Asia, the prevalence and presentation of NAFLD vary widely across regions because of the substantial diversity in race, socioeconomic status and living environment. Furthermore, the dual aetiology of fatty liver, particularly with viral hepatitis in Asia, makes it complex and challenging to manage. Because Asians are likely to have central adiposity and insulin resistance, approximately 7%-20% of non-obese Asians with body mass indexes of less than 25 kg/m 2 are estimated to have NAFLD.Accumulating evidence indicates that NAFLD is associated with various extrahepatic comorbidities such as cardiovascular disease, chronic kidney disease, malignancy, in addition to liver-specific complications. Therefore, NAFLD should be managed as a multisystem disease in conjunction with metabolic syndrome. Lifestyle modification remains the basis of NAFLD management, but few patients can achieve adequate weight loss and maintain it long term. While various pharmacological agents are in phase 3 trials for steatohepatitis, Asian patients are underrepresented in most trials.

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Section: Assessment and Management Of Nafldmentioning

confidence: 99%

Changing clinical management of NAFLD in Asia

Nakatsuka

Tateishi

Koike

2021

Liver International

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“…This is particularly important as waist circumference is used in many scientific publications and scientifically applied scores [19,20]. The FLI score, for example, is widely used as a predictor for NAFLD and metabolic syndrome [21,22] and for evaluating the effect of different treatment methods [23].…”

Section: Discussionmentioning

confidence: 99%

3D Optical Imaging as a New Tool for the Objective Evaluation of Body Shape Changes After Bariatric Surgery

et al. 2020

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Introduction Bariatric surgery is the most effective treatment option for obesity. It results in massive weight loss and improvement of obesity-related diseases. At the same time, it leads to a drastic change in body shape. These body shape changes are mainly measured by two-dimensional measurement methods, such as hip and waist circumference. These measurement methods suffer from significant measurement errors and poor reproducibility. Here, we present a threedimensional measurement tool of the torso that can provide an objective and reproducible source for the detection of body shape changes after bariatric surgery. Material and Methods In this study, 25 bariatric patients were scanned with Artec EVA®, an optical three-dimensional mobile scanner up to 1 week before and 6 months after surgery. Data were analyzed, and the volume of the torso, the abdominal circumference and distances between specific anatomical landmarks were calculated. The results of the processed three-dimensional measurements were compared with clinical data concerning weight loss and waist circumference. Results The volume of the torso decreased after bariatric surgery. Loss of volume correlated strongly with weight loss 6 months after the operation (r = 0.6425, p = 0.0005). Weight loss and three-dimensional processed data correlated better (r = 0.6121, p = 0.0011) than weight loss and waist circumference measured with a measuring tape (r = 0.3148, p = 0.1254). Conclusion Three-dimensional imaging provides an objective and reproducible source for the detection of body shape changes after bariatric surgery. We recommend its use for the evaluation of central obesity, particularly for research issues and body imaging before and after bariatric surgery.

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“…Adapted with permission from Obesity Surgery. 14 Copyright 2019, Springer Science+Business Media patients with proven NASH and obesity, bariatric surgery compared with nonsurgical management was associated with a significantly lower risk for major adverse liver outcomes and major adverse cardiac events. The findings of this study suggest that bariatric surgery can be considered as a therapeutic option for patients with NASH and obesity.…”

Section: Ke Y Point 2: There Is E Vidence That Bari Atric Surgery For...mentioning

confidence: 99%

Section: Key Point 1: Bariatric Surgery Should Be Considered Primary ...mentioning

confidence: 99%

PRO: Should patients with nonalcoholic steatohepatitis fibrosis undergo bariatric surgery as primary treatment?

Orekondy

Lee

Malik

2022

Clinical Liver Disease

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Long-term Results of Bariatric Surgery for Non-alcoholic Fatty Liver Disease/Non-alcoholic Steatohepatitis Treatment in Morbidly Obese Japanese Patients

Cited by 14 publications

References 18 publications

Changing clinical management of NAFLD in Asia

Changing clinical management of NAFLD in Asia

3D Optical Imaging as a New Tool for the Objective Evaluation of Body Shape Changes After Bariatric Surgery

PRO: Should patients with nonalcoholic steatohepatitis fibrosis undergo bariatric surgery as primary treatment?

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