Long-term results of a randomized trial for the treatment of stages B2 and C prostate cancer: radical prostatectomy versus external beam radiation therapy with a common endocrine therapy in both modalities

Akakura, Koichiro; Isaka, Shigeo; Akimoto, Susumu; Itô, Haruo; Okada, Kiyoki; Hachiya, Takahiko; Yoshida, Osamu; Arai, Yoichi; Usami, Michiyuki; Kotake, Toshihiko; Tobisu, Ken Ichi; Ohashi, Yasuo; Sumiyoshi, Yoshiteru; Kakizoe, Tadao; Shimazaki, Jun

doi:10.1016/s0090-4295(99)00106-5

Cited by 69 publications

(45 citation statements)

References 26 publications

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“…As it is standard treatment to add ADT when using radiation, it may be desirable to compare this regimen with RRP in combination with ADT. Akakura et al [18] reported results of a randomized trial comparing RRP and ADT with definitive irradiation and ADT in patients with locally advanced prostate cancer (stage B2 and C). They found 5-year progression-free and CSS of 90.5% and 96.6% in the surgically treated group, which was superior to patients undergoing irradiation (81.2 and 84.6%, respectively).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcome of Patients with High-Risk Prostate Cancer following Radical Prostatectomy and Stage-Dependent Adjuvant Androgen Deprivation

et al. 2010

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Purpose: To present the long-term outcome of high-risk prostate cancer patients treated by radical retropubic prostatectomy (RRP) and stage-dependent adjuvant androgen deprivation therapy. Patients and Methods: Between 1989 and 2005, 2,655 patients underwent RRP by 9 surgeons. All cases (n = 372) with high-risk prostate cancer (serum PSA >20 ng/ml, and/or clinical stage T2c or greater, and/or biopsy Gleason score 8 or greater) were identified and analyzed retrospectively. Results: At 5 and 10 years, cancer-specific survival was 91.3 and 87.2%; overall survival was 84.3 and 72.1%; biochemical progression-free survival (BPFS) was 76.6 and 56.2%; clinical progression-free survival was 86.2 and 79.9%. Kaplan-Meier analysis showed significant differences with respect to pathological stage and Gleason score for cancer-specific survival, BPFS and clinical progression-free survival. In multiple analysis, the only preoperative predictor of BPFS at the 5% level was clinical stage (p = 0.0055). Conclusion: In patients with high-risk prostate cancer and a life expectancy of more than 10 years, RRP with stage-dependent adjuvant androgen deprivation therapy is a viable alternative to radiation therapy.

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Section: Discussionmentioning

confidence: 99%

Long-Term Outcome of Patients with High-Risk Prostate Cancer following Radical Prostatectomy and Stage-Dependent Adjuvant Androgen Deprivation

et al. 2010

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“…In some studies it was administered in an amended version, 37,40 attempting to give a more comprehensive HRQOL assessment for prostate carcinoma patients but altering the psychometric properties of the original tool. Some trials 34,41,47 used only the original version of the EORTC QLQ-C30 without administering any additional measures specifically aimed at detecting aspects related to prostate carcinoma patients; this provides a limited HRQOL assessment for a prostate carcinoma population. Others used the EORTC QLQ-C30 in conjunction with additional measures.…”

Section: Hrqol Assessment Methodologymentioning

confidence: 99%

“…[47][48][49] Bicalutamide, the therapy against which most treatment comparisons were made, was used in seven trials. 26,27,35,36,39,44,46 Radiotherapy was limited to four RCTs.…”

Section: Demographics and Trial Designsmentioning

confidence: 99%

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Health related quality of life in prostate carcinoma patients

Efficace

Bottomley

Andel

2003

Cancer

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Extensive lattice‐Boltzmann simulations were performed to obtain the drag force for random arrays of monodisperse and bidisperse spheres. For the monodisperse systems, 35 different combinations of the Reynolds number Re (up to Re = 1,000) and packing fraction ϕ were studied, whereas for the bidisperse systems we also varied the diameter ratio (from 1:1.5 to 1:4) and composition, which brings the total number of different systems that we considered to 150. For monodisperse systems, the data was found to be markedly different from the Ergun equation and consistent with a correlation, based on similar type of simulations up to Re = 120. For bidisperse systems, it was found that the correction of the monodisperse drag force for bidispersity, which was derived for the limit Re = 0, also applies for higher‐Reynolds numbers. On the basis of the data, a new drag law is suggested for general polydisperse systems, which is on average within 10% of the simulation data for Reynolds numbers up to 1,000, and diameter ratios up to 1:4. © 2007 American Institute of Chemical Engineers AIChE J, 2007.

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“…The efficacy and effectiveness of radical prostatectomy compared to other primary treatments for prostate cancer, including radiotherapy and watchful-waiting (observational management), have not been convincingly demonstrated to date [1][2][3][4][5][6][7][8][9][10][11][12][13]. There have been four randomized trials addressing this issue in patients with localized prostate cancer [11][12][13][14], of which only one demonstrated a survival advantage of radical prostatectomy over watchful-waiting [14].…”

Section: Introductionmentioning

confidence: 99%

Long‐term survival after radical prostatectomy compared to other treatments in older men with local/regional prostate cancer

Liu

Coker

et al. 2008

Journal of Surgical Oncology

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Long-term results of a randomized trial for the treatment of stages B2 and C prostate cancer: radical prostatectomy versus external beam radiation therapy with a common endocrine therapy in both modalities

Cited by 69 publications

References 26 publications

Long-Term Outcome of Patients with High-Risk Prostate Cancer following Radical Prostatectomy and Stage-Dependent Adjuvant Androgen Deprivation

Long-Term Outcome of Patients with High-Risk Prostate Cancer following Radical Prostatectomy and Stage-Dependent Adjuvant Androgen Deprivation

Health related quality of life in prostate carcinoma patients

Long‐term survival after radical prostatectomy compared to other treatments in older men with local/regional prostate cancer

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