Long-term results and prognostic factors of patients with cervical carcinoma treated with concurrent chemoradiotherapy

Reig, A.; Membrive, I.; Arnalot, Palmira Foro; Sanz, X.; Rodríguez, Núria; Lozano, J.; Lacruz, M.; Quera, J.; Fernández-Velilla, Enric; Algara, Manuel

doi:10.1007/s12094-011-0688-8

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…These results are consistent with those of previous studies where tumor size [23,24] and non-squamous histological type [24-26] were identified as prognostic factors for the survival of FIGO stage IIB cervical cancer patients. Thus, the development of new treatment strategies for patients with known risk factors for survival is urgently needed.…”

Section: Discussionsupporting

confidence: 93%

Radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer

Chai

Wang

et al. 2014

BMC Cancer

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BackgroundThe goal of this study was to compare treatment outcomes for Federation of Gynecology and Obstetrics (FIGO) stage IIB cervical carcinoma patients receiving radical surgery followed by adjuvant postoperative radiotherapy versus radical radiotherapy.MethodsMedical records of FIGO stage IIB cervical cancer patients treated between July 2008 and December 2011 were retrospectively reviewed. A total of 148 patients underwent radical hysterectomy with pelvic lymph node dissection followed by adjuvant radiotherapy (surgery-based group). These patients were compared with 290 patients that received radical radiotherapy alone (RT-based group). Recurrence rates, progression-free survival (PFS), overall survival (OS), local control rates, and treatment-related complications were compared for these two groups.ResultsSimilar rates of recurrence (16.89% vs. 12.41%, p = 0.200), PFS (log-rank, p = 0.211), OS (log-rank, p = 0.347), and local control rates (log-rank, p = 0.668) were observed for the surgery-based group and the RT-based group, respectively. Moreover, the incidence of acute grade 3–4 gastrointestinal reactions and late grade 3–4 lower limb lymphedema were significantly higher for the surgery-based group versus the RT-based group. Cox multivariate analyses found no significant difference in survival outcome between the two groups, and tumor diameter and histopathology were identified as significant prognostic factors for OS.ConclusionsRadical radiotherapy was associated with fewer treatment-related complications and achieved comparable survival outcomes for patients with FIGO stage IIB cervical cancer compared to radical hysterectomy followed by postoperative radiotherapy.

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Section: Discussionsupporting

confidence: 93%

Radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer

Chai

Wang

et al. 2014

BMC Cancer

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“…Overall survival was measured from the date of the baseline MR scan to the date of death. Patients who were alive on the closeout date had their survival date censored to that date …”

Section: Methodsmentioning

confidence: 99%

Value of R2* obtained from T2*‐weighted imaging in predicting the prognosis of advanced cervical squamous carcinoma treated with concurrent chemoradiotherapy

Fan

Fang

et al. 2015

Magnetic Resonance Imaging

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“…Currently, it is also difficult to guide the prognosis evaluation of patients and stratify patients with persistent or recurrent disease into risk groups because of the heterogeneity of the associated factors and the radiosensitivity ( 12 ). However, most previous studies have reported these tumor prognostic factors with respect to survival outcomes after the completion of RT ( 7 , 13 ). Although the response after completion of RT is important, we hypothesized that tumor parameters, such as tumor size (TS), tumor volume (TV), and tumor volume reduction rate (TVRR), measured before the intracavitary radiotherapy (ICR), appear to have greater prognostic value ( 10 , 12 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Value of Tumor Size, Volume and Tumor Volume Reduction Rate During Concurrent Chemoradiotherapy in Patients With Cervical Cancer

Sun

Wang

et al. 2022

Front. Oncol.

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ObjectiveThis study aimed to investigate the relationship between prognostic and tumor parameters of cervical cancer patients, such as tumor size (TS), tumor volume (TV), and tumor volume reduction rate (TVRR) after external beam radiotherapy.MethodsA total of 217 patients with advanced cervical cancer, classified as Federation of Gynecology and Obstetrics (FIGO) IIa–IVa, were enrolled in the study. Pre- and mid-RT pelvic magnetic resonance imaging (MRI) were performed twice, during RT and just before brachytherapy.ResultsThe median follow-up time was 51 months (range, 7–111 months). The 5-year overall survival (OS), progression-free survival (PFS), and local failure-free survival (LFFS) rates were 81.3, 85.1, and 92.9%, respectively. Multivariate analysis revealed that tumor parameters including FIGO stage >II (Hazard Ratio, 2.377 and 95% confidence interval [CI], 1.091–5.182; P = 0.029), pre-RT TV >61.6 cm3 (HR, 0.417 and 95% CI, 0.188–0.926; P = 0.032), and mid-RT TV >11.38 cm3 (HR, 3.192 and 95% CI, 1.094–9.316; P = 0.034) were observably associated with OS. Univariate analysis showed that the tumor volume reduction rate (TVRR) was dramatically associated with overall survival (HR, 0.204 and 95% CI 0.033–1.282; P <0.001) and local failure-free survival (P = 0.050).ConclusionsIn this retrospective study, TVRR and mid-radiotherapy tumor volume are independent and strong prognostic parameters for patients with local advanced cervical cancer receiving CCRT.

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Long-term results and prognostic factors of patients with cervical carcinoma treated with concurrent chemoradiotherapy

Abstract: Non-squamous histology and partial response were independent prognostic factors for overall survival and tumour size and partial response were independent prognostic variables for 5-year disease survival.

Cited by 5 publications

References 28 publications

Radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer

Radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer

Value of R2* obtained from T2*‐weighted imaging in predicting the prognosis of advanced cervical squamous carcinoma treated with concurrent chemoradiotherapy

The Prognostic Value of Tumor Size, Volume and Tumor Volume Reduction Rate During Concurrent Chemoradiotherapy in Patients With Cervical Cancer

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