Long-term renal outcomes and mortality following renal injury among myocardial infarction patients treated by primary percutaneous intervention

Kofman, Natalia; Margolis, Gilad; Gal‐Oz, Amir; Letourneau-Shesaf, Sevan; Keren, Gad; Rozenbaum, Zach; Shacham, Yacov

doi:10.1097/mca.0000000000000678

Cited by 25 publications

(32 citation statements)

References 26 publications

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“…Early multiple organ damage is a known predictor of in-hospital and long-term mortality in patients with AMI, and AKI commonly occurs in patients with AMI. [ 30 , 31 ] Patients with AMI having AKI have a 3- to 5.28-fold higher mortality risk than those without AKI. [ 30 , 32 ] sCr is a biomarker of AKI, and the initial sCr levels and daily changes in sCr levels are predictive of in-hospital mortality in patients with or without AMI.…”

Section: Discussionmentioning

confidence: 99%

“…[ 30 , 31 ] Patients with AMI having AKI have a 3- to 5.28-fold higher mortality risk than those without AKI. [ 30 , 32 ] sCr is a biomarker of AKI, and the initial sCr levels and daily changes in sCr levels are predictive of in-hospital mortality in patients with or without AMI. [ 33 , 34 ] Elevated sCr levels have also been associated with peripheral endothelial function dysfunction, and an increase in the sCr levels within the normal range has been independently associated with cardiovascular disease risk in patients without metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of serum albumin-to-creatinine ratio in patients with acute myocardial infarction

Liu

Zhang

et al. 2020

Medicine

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The long-term association between serum albumin-to-creatinine ratio (sACR) and poor patient outcomes in acute myocardial infarction (AMI) remains unclear. This study aimed to determine whether sACR was a predictor of poor long-term survival in patients with AMI. This was a study of patients with AMI in the emergency department (ED) from the retrospective multicenter study for early evaluation of acute chest pain (REACP) study. The patients were categorized into tertiles (T1, T2, and T3) based on the admission sACR (0.445 and 0.584 g/μmol). Baseline sACR at admission to the ED was predictive of adverse outcomes. The primary outcome was all-cause mortality within the follow-up period. Cox proportional hazards models were performed to investigate the association between sACR and all-cause mortality in patients with AMI. A total of 2250 patients with AMI were enrolled, of whom 229 (10.2%) died within the median follow-up period of 10.7 (7.2–14.6) months. Patients with a lower sACR had higher all-cause mortality and adverse outcomes rates than patients with a higher sACR. Kaplan–Meier survival analysis showed that patients with a higher sACR had a higher cumulative survival rate ( P < .001). Cox regression analysis showed that a decreased sACR was an independent predictor of all-cause mortality [T2 vs T1: hazard ratio (HR); 0.550, 95% confidence interval (95% CI), 0.348–0.867; P = .010 and T3 vs T1: HR, 0.305; 95% CI, 0.165–0.561; P < .001] and cardiac mortality (T2 vs T1: HR, 0.536; 95% CI, 0.332–0.866; P = .011 and T3 vs T1: HR, 0.309; 95% CI, 0.164–0.582, P < .001). The sACR at admission to ED was independently associated with adverse outcomes, indicating that baseline sACR was a useful biomarker to identify high-risk patients with AMI at an early phase in ED.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic value of serum albumin-to-creatinine ratio in patients with acute myocardial infarction

Liu

Zhang

et al. 2020

Medicine

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“…Underlying CKD is a known risk factor for contrast-induced nephropathy (CIN), and prior studies have shown these patients are more likely to progress 14 . In the Kofman et al study 9 , AKD was more frequent in patients with underlying CKD. However, there is no information on the distribution of AKD and outcomes among patients with CKD in comparison to de novo AKI.…”

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confidence: 84%

“…However, the heterogeneity of AKI etiology, its recognition and management has been a limiting factor in identifying these events in epidemiologic studies and for individualized patient management. A key issue is the difficulty in distinguishing a new episode of AKI from preexisting CKD and persistent AKI with incomplete recovery 6-8 . In this issue of the journal, Kofman et al 9 report on the outcomes of patients identified as having AKI following primary percutaneous coronary interventions (PCI) for ST-elevation myocardial infarctions (STEMI) in a single center. Over a course of 8 years, 2122 patients underwent PCI for STEMI, of whom 225 developed AKI within 7 days based on the KDIGO serum creatinine criteria.…”

mentioning

confidence: 99%

“…In the Action Get with the Guidelines-CAD Registry, over 182 thousand patients underwent PCI for STEMI in the US in 2014 24 . Based on the reported AKI incidence of 10% in prior studies and the Kofman et al 9 data, approximately 18000 patients a year would have developed AKI and 6480 would have had AKD with a high risk of developing new-onset CKD, CKD progression and mortality. These numbers would be further magnified if one considers the broader category of PCI for non-STEMI applications 24 .…”

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confidence: 99%

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Does acute kidney disease following primary percutaneous coronary intervention lead to chronic kidney disease development and progression?

Macedo

Mehta²

2019

Coronary Artery Disease

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Incidence and outcomes of acute kidney injury stratified by cardiogenic shock severity

Padkins

Breen

Diepen

et al. 2021

Cathet Cardio Intervent

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Background Acute kidney injury (AKI) is common among patients with cardiogenic shock (CS) and it is independently associated with mortality. We sought to assess the prevalence, severity, and prognosis of AKI as a function of cardiogenic shock severity in unselected Cardiac Intensive Care Unit (CICU) patients. Methods We retrospectively reviewed admissions to the Mayo Clinic between 2007 to 2015 and stratified patients by the AKI stage (based on modified Kidney Disease: Improving Global Outcomes criteria) and Society for cardiovascular angiography and interventions (SCAI) shock stage. The association with in‐hospital mortality was analyzed using multivariable logistic regression. Results We included 9,311 unique patients with a mean age of 67 years and 37% females. SCAI shock stages A, B, C, D, and E were present in 47%, 30%, 15%, 7%, and 1% of patients. The incidence of AKI of any severity was 39% in the CICU and 51% during the hospitalization. Hospital mortality occurred in 8% of all patients, and the risk increased as a function of the rising AKI and SCAI shock stage. Worsening AKI stage was associated with increased adjusted hospital mortality (adjusted OR per AKI stage 1.22, 95% CI 1.10–1.36, p < .001). Higher AKI stages were associated with increased adjusted hospital mortality in SCAI stage A/B (p < .001), but not in SCAI stage C, D, or E (all p > .05). Conclusions Higher AKI stages were independently associated with mortality in CICU patients after accounting for shock severity and may add incremental prognostic utility in patients with lower SCAI stages.

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Long-term renal outcomes and mortality following renal injury among myocardial infarction patients treated by primary percutaneous intervention

Cited by 25 publications

References 26 publications

Prognostic value of serum albumin-to-creatinine ratio in patients with acute myocardial infarction

Prognostic value of serum albumin-to-creatinine ratio in patients with acute myocardial infarction

Does acute kidney disease following primary percutaneous coronary intervention lead to chronic kidney disease development and progression?

Incidence and outcomes of acute kidney injury stratified by cardiogenic shock severity

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