Long-Term Renal Function Following Radical Cystectomy for Bladder Cancer

Vejlgaard, Maja; Maibom, Sophia Liff; Stroomberg, Hein Vincent; Poulsen, Alicia Martin; Thind, Peter; Røder, Martin Andreas; Joensen, Ulla Nordström

doi:10.1016/j.urology.2021.11.015

Cited by 14 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The negative impact of RC on kidney function is known but has not previously been evaluated with the retrosigmoid ileal conduit [19] . In our study, evaluation of short-term renal function after RC with serum creatinine and renography shows no differences between the two conduits.…”

Section: Discussionmentioning

confidence: 99%

DaBlaCa-16: Retrosigmoid Versus Conventional Ileal Conduit in Robot-assisted Radical Cystectomy, the MOSAIC Randomized Controlled Trial—Feasibility and 90-day Postoperative Complications

Brandt,

Körner,

Milling

et al. 2024

European Urology Open Science

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

DaBlaCa-16: Retrosigmoid Versus Conventional Ileal Conduit in Robot-assisted Radical Cystectomy, the MOSAIC Randomized Controlled Trial—Feasibility and 90-day Postoperative Complications

Brandt,

Körner,

Milling

et al. 2024

European Urology Open Science

View full text Add to dashboard Cite

“…In a previous study, the CKD-EPI eGFR equation demonstrated the greatest precision and accuracy, and the least bias among four formulas for comparing renal function before and after nephrectomy: Cockcroft-Gault, Modification of Diet in Renal Disease Study, reexpressed Modification of Diet in Renal Disease Study, and Chronic Kidney Disease-Epidemiology Study equations [ 15 ]. Recently published studies comparing the renal function of patients who underwent cystectomy also used the CKD-EPI equation for assessing renal function decline [ 17 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…To determine renal function decline, our study referred to previous journals and combined various definitions using different values and ratios [ 13 16 17 18 19 20 21 22 23 24 ]. The follow-up duration and interval were different between previous studies; we followed up the renal function after cystectomy for 5 years.…”

Section: Discussionmentioning

confidence: 99%

“…To test the consistency of the change in renal function following RC, we used various methods to assess the renal function, including (i) serum creatinine level, (ii) eGFR (CKD-EPI and MDRD), (iii) eGFR difference value (preoperative value–follow-up value), and (iv) eGFR difference proportion (eGFR difference value/preoperative eGFR) at 1, 3, 6, 12, 24, 36, 48, and 60 months [ 16 17 18 19 ]. Furthermore, eGFR decline was assessed using various definitions: (i) 10 points decline in eGFR, (ii) 10% decline in eGFR, and (iii) 20% decline in eGFR [ 13 19 ].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Renal function change after radical cystectomy for urothelial carcinoma patients with a solitary kidney may be independent of urinary diversion type

et al. 2023

View full text Add to dashboard Cite

Purpose To compare renal function change by urinary diversion (UD) type (ileal conduit [IC] vs. neobladder [NB]) in patients with a single kidney who underwent radical cystectomy (RC) due to bladder cancer. Materials and Methods We evaluated the renal function change in 86 patients with a single kidney who underwent RC between January 1999 and August 2022. Renal function was assessed using serum creatinine, serum estimated glomerular filtration rate (eGFR), eGFR difference value (preoperative and follow-up values), and eGFR difference proportion (eGFR difference value/preoperative eGFR) at 1, 3, 6, 12, 24, 36, 48, and 60 months. In addition, multiple definitions of eGFR decline were evaluated: 10 points, 10%, and 20% decline in eGFR. Cox regression models were used to identify risk factors of eGFR decline-free, recurrence-free, overall, and cancer-specific survival rates. Results A total of 54 patients (62.8%) underwent IC, whereas 32 (37.2%) underwent NB. Baseline characteristics were similar between the two groups except for age and body mass index. Renal functions over time by various methods did not differ significantly between the IC and NB groups. Furthermore, eGFR decline-free survival rate using different definitions was similar between the IC and NB groups. Overall survival, recurrence-free survival, and cancer-specific-free survival rates were not different between the IC and NB groups. Conclusions UD type (IC vs. NB) did not impact the renal function change of patients with a single kidney who underwent RC. Therefore, patients with a single kidney might be considered to be an indication of NB.

show abstract

“…The effect of urinary diversion types on the long-term renal function has yet to be determined. Although some studies reported a negative impact of orthotopic neobladder on postoperative renal function [53], high-level evidence is available supporting the long-term safety of this type of diversion. Iqbal et al [54] reported similar postoperative GFR up to 5 years following RC with neobladder vs. ileal conduit.…”

Section: Renal Function Deteriorationmentioning

confidence: 99%

Comparative performance of the different orthotopic urinary diversions

Moghaddam

Ghoreifi

Djaladat

2022

Current Opinion in Urology

View full text Add to dashboard Cite

Purpose of reviewMajority of patients undergoing radical cystectomy are suitable for orthotopic urinary diversion. The effect of different techniques of neobladder reconstruction on early and long-term postoperative complications is still being determined. Additionally, it is unclear which type of neobladder provides the best patient satisfaction. The purpose of this article is to review the outcomes of different orthotopic urinary diversions following radical cystectomy.Recent findingsIleal neobladder is the preferred type of orthotopic urinary diversion following radical cystectomy. Hautmann and Studer, which are the most common orthotopic diversion techniques, provide daytime continence rate up to 87% and 92%, respectively. However, nighttime continence is achieved in about 50% of patients. High-level evidence supports the long-term safety of orthotopic neobladder in terms of renal function, even in patients with a glomerular filtration rate <60 ml/min. Sexual dysfunction is the only independent factor associated with poorer quality of life in these patients.SummaryThe best type of neobladder is still uncertain. However, Studer and Hautmann are the most commonly performed techniques that provide favorable short- and long-term outcomes.

show abstract

Long-Term Renal Function Following Radical Cystectomy for Bladder Cancer

Cited by 14 publications

References 16 publications

DaBlaCa-16: Retrosigmoid Versus Conventional Ileal Conduit in Robot-assisted Radical Cystectomy, the MOSAIC Randomized Controlled Trial—Feasibility and 90-day Postoperative Complications

DaBlaCa-16: Retrosigmoid Versus Conventional Ileal Conduit in Robot-assisted Radical Cystectomy, the MOSAIC Randomized Controlled Trial—Feasibility and 90-day Postoperative Complications

Renal function change after radical cystectomy for urothelial carcinoma patients with a solitary kidney may be independent of urinary diversion type

Comparative performance of the different orthotopic urinary diversions

Contact Info

Product

Resources

About