Long Term Remission Survival with a Case of Rectal Carcinoid Tumor with Metastasis in the Soft Tissue Effectively Treated with the Combination Therapy of Irinotecan/5-fluorouracil/levofolinate Followed by Resection

Wada, Yuko; Hirayama, Yasuo; Seki, Ryouya; Konuma, Yuichi; Kohda, Kyuhei; Yoshida, Makoto; Nakamura, Yutaka; Obata, Masahiko; Ando, Motomi

doi:10.2169/naika.96.2513

Cited by 5 publications

(8 citation statements)

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“…Combination chemotherapies, including 5-fluorouracil [ 35 ], dacarbazine, etoposide [ 36 ] and doxorubicin [ 37 ], may prolong survival for patients with distant metastatic disease. Somatostatin analogues, such as octreotide and lanreotide, have also been shown to prolong survival.…”

Section: Discussionmentioning

confidence: 99%

Management of sub-5 mm rectal carcinoids with lymph node metastases

Toh

Henderson

Yabe

et al. 2014

Gastroenterology Report

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Minute (<5 mm) and small (5–10 mm) rectal carcinoids discovered during colonoscopy are generally considered to be non-aggressive, and the management and surveillance of patients with this entity are usually limited. We present the case of a 61-year-old Chinese female with multiple sub-5 mm carcinoid tumours in the rectum without any computed tomography (CT) evidence of lymph node or distant metastases. She underwent an ultra-low anterior resection for a sessile rectal polyp with the histological appearance of a moderately differentiated adenocarcinoma. Seven foci of minute carcinoids in the rectum and perirectal lymph node metastastic spread from the carcinoid tumours were also discovered on histopathology. There were no lymph node metastases originating from adenocarcinoma. This case report and review of the literature suggests that minute rectal carcinoids are at risk of metastasizing and that these patients should be investigated for lymph node and distant metastatic spread with CT and somatostatin receptor scintigraphy or its equivalent, as this would influence prognosis and surgical management of these patients. Findings relating to lymphovascular invasion, perineural invasion, high Ki-67, mitotic rate, depth of tumour invasion, central ulceration, multifocal tumours and size are useful in predicting metastases and may be used in scoring tools. Size alone is not a good predictor of metastastic spread.

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Section: Discussionmentioning

confidence: 99%

Management of sub-5 mm rectal carcinoids with lymph node metastases

Toh

Henderson

Yabe

et al. 2014

Gastroenterology Report

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“…IFO (10,11) and anthracycline anti-tumor drugs (11,12), including THP, ADM and EPI, are the first choice in the chemotherapy of soft tissue tumors. CDDP (13), VCR (13) and 5-FU (14,15) are also reported to be effective against soft tissue tumors. In this case, we used the system of CD-DST described by kobayashi et al (2-4) to check the sensitivity of tumor cells to THP, VCR, CDDP and 5-FU.…”

Section: Discussionmentioning

confidence: 99%

“…Isophosphamide (IFO) (10,11) and anthracycline anti-tumor drugs (11,12), including therarubicin (THP), adriamycin (ADM) and epirubicin (EPI), are the first choice in the chemotherapy of soft tissue tumors. Cisplatin (CDDP) (13), vincristine (VCR) (13) and 5-fluorouracil (5-FU) (14,15) have also been reported to be effective against soft tissue tumors. CDDP, THP, VCR and 5-FU were examined in CD-DST.…”

Section: Methodsmentioning

confidence: 99%

Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report

Fan

et al. 2010

Oncology Letters

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The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28-year old man presented at our hospital with a large mass in his right shank which had a hard texture and an obscure boundary. The histopathological diagnosis of excisional biopsy specimens was synovial sarcoma with low differentiation. Theprubicin/Cisplatin (THP/CDDP) neoadjuvant chemotherapy was selected based on the results obtained from the CD-DST. After three courses, a computed tomography (CT) scan was performed which indicated that the volume of the tumor had decreased significantly. Additionally, tumor necrosis, as well as the clinical response, showed complete response. The histopathological diagnosis of wide excision specimens indicated a grade III chemotherapy response. The patient was alive and without recurrence after a follow-up of 16 months. Our results indicated that the CD-DST is a useful tool for selecting neoadjuvant chemotherapeutic drugs for patients with synovial sarcoma.

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“…and doxorubicin or streptozocin/dacarbazine [221,222], or the full oral temozolomide and capecitabine regimen (CAPTEM) are usually opted for [223]. Some reports also indicate the efficacy of the combination of oxaliplatin and 5-FU derivatives [224] or irinotecan with 5-FU [225].…”

Section: Guidelinesmentioning

confidence: 99%

Update of the diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours) [Aktualizacja zaleceń ogólnych dotyczących postępowania diagnostyczno-terapeutycznego w nowotworach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]

et al. 2022

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially  388 Guidelines Beata Kos-Kudła et al. Guidelinespersons/year, with the primary lesion most frequently found in the small intestine (37.4%). Since 2000, rectal NENs have been diagnosed more frequently than small intestine NENs [2, 6-8]. The incidence of GEP-NETs in the USA, based on SEER data, was 3.56/100,000 persons/year. In Europe, the incidence of GEP-NETs is also increasing -from 1.33 to 2.33/100,000 persons/year; however, these data come from different registries and are mainly retrospective. Higher incidence is observed among men (5.35/100,000 persons/year) compared to women (4.76/100,000 persons/year) [1, 5-7]. The vast majority of NENs are sporadic, well-differentiated tumours. However, GEP-NETs originating from the pancreas, duodenum, stomach, and much less frequently, from the thymus and lungs sometimes constitute an element of multiple endocrine neoplasia type 1 (MEN-1) syndrome. Pancreatic neuroendocrine tumours (PanNETs) may also be associated with von Hippel-Lindau (VHL) syndrome, tuberous sclerosis complex (TSC), and neurofibromatosis (NF). In these congenital diseases, NETs can be multifocal and occur 10-20 years earlier than in sporadic cases. The frequency of the hereditary causes (MEN-1, VHL) is estimated at about 5%. Genome studies revealed the presence of germline mutations in, e.g., MUTYH, CHEK2, and BRCA2 and a propensity to PanNETs in approximately 17% of the studied population [1]. Diagnostics Biochemical diagnosticsBiochemical diagnostics of NENs involves the following: A. Non-specific markersThe most frequently used diagnostic method is determination of the chromogranin A (CgA) concentration in the serum (less frequently in the plasma) [1,8,9]. CgA is a relatively stable protein in blood. However, there are two different methods for determining the concentration of CgA: radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) in Neuroendocrine neoplasms (NENs) arise from the disseminated system of neuroendocrine cells and can occur in various parts of the body. However, they are most often found in the gastrointestinal tract and lungs. The term NENs includes both well-differentiated neuroendocrine tumours and neuroendocrine carcinomas (NECs), which account for 10-20% of all NENs. The following characteristics of NENs should be considered in the diagnostic and therapeutic process: proliferative activity, presence of somatostatin receptors (SSTRs), tumour growth rate, and extent of the neoplastic disease [1].

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Long Term Remission Survival with a Case of Rectal Carcinoid Tumor with Metastasis in the Soft Tissue Effectively Treated with the Combination Therapy of Irinotecan/5-fluorouracil/levofolinate Followed by Resection

Cited by 5 publications

References 4 publications

Management of sub-5 mm rectal carcinoids with lymph node metastases

Management of sub-5 mm rectal carcinoids with lymph node metastases

Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report

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