Long-term recurrences of jaw osteoradionecrosis after apparent healing with the PENTOCLO protocol

Dinnoo, A.; Bidault, François; Lassau, Nathalie; Elmaalouf, M.; Moya‐Plana, Antoine; Ruffier, A.; Janot, F.; Benmoussa, Nadia

doi:10.1016/j.jormas.2019.06.007

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…84 A daily three-drug regimen is also effective for treating osteoradionecrosis; however, no studies to date have examined its effectiveness as a protective agent. 56,81,[95][96][97] Further RCTs are necessary to determine whether PENTOCLO also has a prophylactic role in supporting oncologic treatments.…”

Section: Pentoxifylline-tocopherol-clodronatementioning

confidence: 99%

Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review

Kim

Rubenstein

Chu

et al. 2022

J Reconstr Microsurg

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Background Radiation-associated soft tissue injury is a potentially devastating complication for head and neck cancer patients. The damage can range from minor sequelae such as xerostomia, which requires frequent daily maintenance, to destructive degenerative processes such as osteoradionecrosis, which can contribute to flap failure and delay or reverse oral rehabilitation. Despite the need for effective radioprotectants, the literature remains sparse, primarily focused on interventions beyond the surgeon's control, such as maintenance of good oral hygiene or modulation of radiation dose. Methods This narrative review aggregates and explores noninvasive, systemic treatment modalities for prevention or amelioration of radiation-associated soft tissue injury. Results We highlighted nine modalities with the most clinical potential, which include amifostine, melatonin, palifermin, hyperbaric oxygen therapy, photobiomodulation, pentoxifylline–tocopherol–clodronate, pravastatin, transforming growth factor-β modulators, and deferoxamine, and reviewed the benefits and limitations of each modality. Unfortunately, none of these modalities are supported by strong evidence for prophylaxis against radiation-associated soft tissue injury. Conclusion While we cannot endorse any of these nine modalities for immediate clinical use, they may prove fruitful areas for further investigation.

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Section: Pentoxifylline-tocopherol-clodronatementioning

confidence: 99%

Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review

Kim

Rubenstein

Chu

et al. 2022

J Reconstr Microsurg

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Managing Mandibular Osteoradionecrosis

Fritz,

Arianpour,

Liu

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveMandibular osteoradionecrosis (MORN) is a morbid complication of head and neck radiation therapy. Recent advances in surgical and medical therapies underscore the need for a shift in traditional treatment paradigms and a disease grading system that can guide appropriate management.Data SourcesPubmed/MEDLINE.Review MethodsWe conducted a detailed review of publications related to MORN, specifically focusing on its staging and management techniques. Articles meeting inclusion criteria were synthesized into a final narrative review.ConclusionThere has been a paradigm shift away from hyperbaric oxygen therapy in the management of MORN. Growing evidence for the efficacy of pentoxifylline and tocopherol in early‐stage disease and novel surgical techniques to manage moderate and late‐stage disease warrant an updated staging stratification which is proposed.Implications for PracticeThis review summarizes the clinical efficacy of established and novel therapeutic modalities currently available in treating MORN, emphasizing the significant advances achieved over the last decade. It introduces a contemporary staging and treatment algorithm which incorporates traditional, evidence‐supported surgical and medical management with effective early intervention strategies.

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Long-term recurrences of jaw osteoradionecrosis after apparent healing with the PENTOCLO protocol

Cited by 2 publications

References 9 publications

Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review

Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review

Managing Mandibular Osteoradionecrosis

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