Long-Term Recurrence Rates of Atypical Meningiomas After Gross Total Resection With or Without Postoperative Adjuvant Radiation

Aghi, Manish K.; Carter, Bob S.; Cosgrove, G. Rees; Ojemann, Robert G.; Amin‐Hanjani, Sepideh; Martuza, Robert L.; Curry, William T.; Barker, Fred G.

doi:10.1227/01.neu.0000330399.55586.63

Cited by 422 publications

(322 citation statements)

References 12 publications

Supporting

Mentioning

293

Contrasting

Unclassified

Order By: Relevance

“…34,41,49 Three retrospective studies advocated the use of adjuvant EBRT after GTR of AM (Table 3). 2,3,45 These studies reported improved LC or a trend toward improved LC with adjuvant EBRT and GTR versus GTR alone (p = 0.04, p = 0.09, and p = 0.10; tine adjuvant EBRT after GTR (Table 3). 13,24,26,37,46,48,59,78,81,85 Eight of these 10 studies did not detect any significant improvement in PFS with adjuvant EBRT, and the remaining 2 studies did not detect any significant improvement in LC.…”

Section: Adjuvant Ebrt After Gtrmentioning

confidence: 96%

See 1 more Smart Citation

An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas

Sun¹,

Hawasli²,

Huang

et al. 2015

FOC

115

View full text Add to dashboard Cite

The management of WHO Grade II “atypical” meningiomas (AMs) and Grade III “malignant” meningiomas (MMs) remains controversial and under-investigated in prospective studies. The roles of surgery, radiation therapy, radiosurgery, and chemotherapy have been incompletely delineated. This has left physicians to decipher how they should treat patients on a case-by-case basis. In this study, the authors review the English-language literature on the management and clinical outcomes associated with AMs and MMs diagnosed using the WHO 2000/2007 grading criteria. Twenty-two studies for AMs and 7 studies for MMs were examined in detail. The authors examined clinical decision points using the literature and concepts from evidence-based medicine. Acknowledging the retrospective nature of the studies concerning AM and MM, the authors did find evidence for the following clinical strategies: 1) maximal safe resection of AM and MM; 2) active surveillance after gross-total resection of AM; 3) adjuvant radiation therapy after subtotal resection of AM, especially in the absence of putative radioresistant features; and 4) adjuvant radiation therapy after resection of MM.

show abstract

Section: Adjuvant Ebrt After Gtrmentioning

confidence: 96%

“…For example, Aghi et al 2 reported that although none of 8 patients receiving adjuvant EBRT suffered a recurrence, 1 patient developed radiation necrosis, which was subsequently treated with resection. In other studies on AMs, radiation necrosis occurred in 4.2% and 10.2% of patients.…”

Section: Adjuvant Ebrt After Gtrmentioning

confidence: 99%

An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas

Sun¹,

Hawasli²,

Huang

et al. 2015

FOC

115

View full text Add to dashboard Cite

show abstract

“…Atypical meningiomas carry a 7-to 8-fold increased risk of recurrence and a 2-fold increased risk of death at 3-5 years after resection. 1,36 It is generally accepted that complete removal of these lesions, with or without radiation therapy, is important for survival. Intraoperative frozen section pathology can be performed early during tumor removal to help guide the extent of resection.…”

Section: Surgical Planningmentioning

confidence: 99%

Management of meningiomas involving the transverse or sigmoid sinus

Mazur¹,

Cutler²,

Couldwell³

et al. 2013

FOC

View full text Add to dashboard Cite

Meningiomas that invade the transverse or sigmoid sinuses are uncommon tumors that are challenging to treat surgically. Although the risk of recurrence is associated with the extent of resection, complete removal of meningiomas in these locations must be balanced with avoidance of venous outflow obstruction, which could cause venous infarction and significant neurological consequences. When a meningioma occludes a venous sinus completely, gross-total resection of the intravascular portion is commonly performed. When the tumor invades but does not completely obliterate a major venous sinus, however, opinions differ on whether to accept a subtotal resection or to open the sinus, perform a complete resection, and reconstruct the venous outflow tract. In this paper, the authors review the different strategies used to treat these lesions and provide illustrative case examples.

show abstract

“…[8] Benin menenjiomlarda subtotal rezeksiyon sonrası radyoterapi tümör progresyonunu azaltırken sağkalıma faydası yoktur. [7,15,16] Stereotaktik radyoterapi/radyocerrahi özellikle 3-4 cm altında, belirli sınırı olan ve kritik organlardan güvenli bir uzaklıkta olan tümörlerde uygulanabilir. 972 hastanın alındığı büyük bir çalışmada 1045 intrakraniyal menenjioma SRT uygulanmış-tır.…”

Section: Discussionunclassified

“…The patients were administered an average dose of 20 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) Gy with a CyberKnife machine using an average of 3 (1-5) fractions.…”

Section: Methodsmentioning

confidence: 99%

Stereotactic radiotherapy results of menengiomas with a CyberKnife: a single center experience

Isik¹

2014

TJ Oncol

View full text Add to dashboard Cite

Long-Term Recurrence Rates of Atypical Meningiomas After Gross Total Resection With or Without Postoperative Adjuvant Radiation

Cited by 422 publications

References 12 publications

An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas

An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas

Management of meningiomas involving the transverse or sigmoid sinus

Stereotactic radiotherapy results of menengiomas with a CyberKnife: a single center experience

Contact Info

Product

Resources

About