Long-term recurrence of primary amyloidosis of the bladder

Ruffion, A.; Valignat, C.; Champetier, D.; López, José González; Perrin, Peggy; Devonec, M

doi:10.1016/s0090-4295(01)01565-5

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Regardless of lesional size, isolated amyloidosis of the genitourinary tract has been reported to have a high recurrence rate (>50%); however, no disease-associated mortality has been reported [18]. Following an initial systemic work-up for amyloidosis, long-term follow-up is recommended as recurrences have been reported several years after initial diagnosis [17,26]. …”

Section: Resultsmentioning

confidence: 99%

Urinary Cytopathology in Primary Bladder Amyloidosis

Toll

Ali²

2013

Acta Cytologica

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Background: Amyloidosis results from the accumulation of unique extracellular proteins which are not able to be degraded via the usual mechanism of lysosomal proteolysis. Isolated collections of amyloid within the bladder are extremely uncommon, and a cytopathologic description in voided urine has not been described to date. Methods: A retrospective review was performed at a tertiary-care hospital, and 3 patients with isolated bladder amyloidosis and corresponding voided urine specimens were identified. The following clinical data were collected for each case: age, gender, treatment and follow-up information. Results: The patient age range was 76-84 years, with 2 males and 1 female. Amyloidosis was never clinically suspected. In 1 patient, a urinary amyloid manifested, which was thought to represent extraneous debris at the time of original diagnosis. Two patients never manifested signs of systemic amyloidosis or multiple myeloma, and the third was found to have a monoclonal gammopathy. Conclusions: Our results show the difficulty of diagnosing urinary amyloid in the absence of clinical suspicion. Further, the presence of urinary amyloid is unlikely in patients with bladder amyloidosis as the cohesive nature of the protein makes spontaneous shedding uncommon. Testing for systemic amyloidosis is warranted and if the disease is localized, a favorable outcome can be expected.

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Section: Resultsmentioning

confidence: 99%

Urinary Cytopathology in Primary Bladder Amyloidosis

Toll

Ali²

2013

Acta Cytologica

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“…Computed tomography shows single or multiple bulging lesions on the bladder wall, which can be easily confused with bladder malignancies. 8 …”

Section: Discussionmentioning

confidence: 99%

“… 6 Although many treatment methods are available the recurrence rate of this disease is as high as 54%, 7 Delayed recurrence may occur 14 years after the first diagnosis. 8 Dimethyl sulfoxide (DMSO) bladder perfusion can be used to treat or prevent recurrence, and one treatment course lasts for 6 to 12 months. 9 There are also reports of satisfactory outcomes by administration of cephalexin together with bladder infusion of DMSO.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous remission of untreated primary amyloidosis of the bladder after transurethral resection biopsy: a case report and literature review

Jia

Liu

2020

J Int Med Res

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We herein present a case involving a 23-year-old woman with gross hematuria. Cystoscopy revealed abnormal areas of the mucosa along the anterior and posterior bladder walls. These abnormalities were suspicious for neoplasia; however, a diagnosis was not established by subsequent biopsy. The patient underwent transurethral resection biopsy in which an isolated lesion along the anterior wall was completely resected and the others were left untreated. Pathologic examination and special staining led to a diagnosis of amyloidosis, and the patient elected to undergo transurethral surgery 1 month later. During the operation, the intravesical lesions were found to have significantly improved in both the treated and untreated sites. The operation was cancelled, follow-up was arranged, and no other treatment was administered. Repeat cystoscopy examinations at 3 and 9 months after surgery showed that the lesions had almost completely disappeared.

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“…In this regard, we have observed induction of established tubular markers within primary cultures of KiSAS cells in response to modulation with known morphogenic agents such as retinoic acid (our unpublished observations). Renal adipose may represent a potentially ideal alternate cell source for treatment of chronic anemia secondary to CKD, since renal adipose can be isolated in much larger quantities than renal primary cells and, as is the case for adipose associated with tubular organs such as bladder, may be unaffected by the occurrence of metastasis in renal cancer patients [46,47]. …”

Section: Discussionmentioning

confidence: 99%

Organ specific regenerative markers in peri-organ adipose: kidney

et al. 2011

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BackgroundTherapeutically bioactive cell populations are currently understood to promote regenerative outcomes in vivo by leveraging mechanisms of action including secretion of growth factors, site specific engraftment and directed differentiation. Constitutive cellular populations undoubtedly participate in the regenerative process. Adipose tissue represents a source of therapeutically bioactive cell populations. The potential of these cells to participate in various aspects of the regenerative process has been demonstrated broadly. However, organ association of secretory and developmental markers to specific peri-organ adipose depots has not been investigated. To characterize this topographical association, we explored the potential of cells isolated from the stromal vascular fraction (SVF) of kidney sourced adipose to express key renal associated factors.ResultsWe report that renal adipose tissue is a novel reservoir for EPO expressing cells. Kidney sourced adipose stromal cells demonstrate hypoxia regulated expression of EPO and VEGF transcripts. Using iso-electric focusing, we demonstrate that kidney and non-kidney sourced adipose stromal cells present unique patterns of EPO post-translational modification, consistent with the idea that renal and non-renal sources are functionally distinct adipose depots. In addition, kidney sourced adipose stromal cells specifically express the key renal developmental transcription factor WT1.ConclusionsTaken together, these data are consistent with the notion that kidney sourced adipose stromal (KiSAS) cells may be primed to recreate a regenerative micro-environment within the kidney. These findings open the possibility of isolating solid-organ associated adipose derived cell populations for therapeutic applications in organ-specific regenerative medicine products.

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Long-term recurrence of primary amyloidosis of the bladder

Cited by 6 publications

References 6 publications

Urinary Cytopathology in Primary Bladder Amyloidosis

Urinary Cytopathology in Primary Bladder Amyloidosis

Spontaneous remission of untreated primary amyloidosis of the bladder after transurethral resection biopsy: a case report and literature review

Organ specific regenerative markers in peri-organ adipose: kidney

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