Long-Term Recreational Football Training and Health in Aging

Imperlini, Esther; Mancini, Annamaria; Orrú, Stefania; Vitucci, Daniela; Onofrio, Valeria Di; Gallé, Francesca; Valerio, Giuliana; Salvatore, Giuliana; Liguori, Giorgio; Buono, Pasqualina; Alfieri, Andreina

doi:10.3390/ijerph17062087

Cited by 5 publications

(6 citation statements)

References 102 publications

(124 reference statements)

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“…Regular exercise training mediates the reduction in the risk of chronic non-communicable diseases (NMCT), including cancer (Cartee et al 2016 ; Gebel et al 2015 ; Kyu et al 2016 ) and promotes wellbeing and longevity (Garatachea et al 2015 ), also through the regulation of miRNAs and protein expression. In the last few years, adapted sport training, particularly football, has been reported as holistic positive paradigm, linking training to improved cardiovascular, metabolic and musculoskeletal fitness, also in the elderly (Krustrup et al 2010a , 2018 ; Bangsbo et al 2015 ; Andersen et al 2016 ; Krustrup and Krustrup 2018 ; Imperlini et al 2020 ). Regular training promotes successful ageing, activating the autophagy process in muscle tissue (Fan et al 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Regular football training down-regulates miR-1303 muscle expression in veterans

et al. 2021

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Purpose Regular exercise affects the expression of several genes, proteins and microRNAs (miRNAs) in time- and intensity-dependent manner promoting longevity. We previously identified from GeneChip Array analysis several differentially expressed genes and miRNAs in muscle from veteran football players (VPG) compared to active untrained elderly subjects (CG); here we focussed on miRNA-1303 (miR-1303). The aims of the present research were: to analyse the effects of football training on the expression of miR-1303 and to identify its putative target involved in the longevity pathways in skeletal muscle from VPG compared to CG. Methods RNA samples from 12 VPG and 12 CG muscle biopsies were used to validate miR-1303 expression. Crossing four different bioinformatic algorithms, we identified 16 putative targets of miR-1303; from these, BAG-2, KLHL7 and KBTBD6 were chosen for further validation by Western blot analysis in LHCN-M2 human myoblasts transiently transfected with miR-1303. Results Football training down-regulates miR-1303 expression in muscle from VPG compared to CG and the expression of BAG-2, a chaperon protein involved in the autophagy pathway, inversely correlated to overexpression of miR-1303 in a time-dependent manner, indicating that it is a miR-1303 potential target. Conclusions This is the first report, to our knowledge, describing miR-1303 regulation in skeletal muscle by football training and the identification of a target protein, BAG-2, involved in the autophagy pathway. This result contributes to the enlargement of knowledge on the molecular mechanisms linking football training, autophagy and longevity.

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Section: Discussionmentioning

confidence: 99%

Regular football training down-regulates miR-1303 muscle expression in veterans

et al. 2021

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“…Aging is a continuous physiological process of the human body that begins in early adulthood with the onset of multiple changes at the cell/tissue level (cellular homeostasis alteration, DNA accumulation and protein damage) [ 1 , 2 , 3 ], eventually leading to a functional decline in organs/systems [ 4 , 5 , 6 ]. In fact, this structural and functional decay affects the cardiovascular, the musculoskeletal and the nervous system, initiating various age-related non-communicable diseases (NCDs), such as Type 2 diabetes mellitus (T2DM), hypertension, insulin resistance (IR), cognitive decline and Alzheimer’s disease [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have reported that individuals who engage in PA age successfully, characterized by a low risk of age-related disabilities in comparison with age-matched sedentary adults [ 14 , 15 ]. Regular physical activity, in fact, exerts its effects on metabolic regulation and the maintenance of metabolic homeostasis [ 16 ], especially when the WHO’s guidelines, which recommend both aerobic and resistance exercise, are met [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players

Orrú

Imperlini

Vitucci

et al. 2022

IJERPH

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Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging. Methods: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools. Results: Our results indicated that lifelong football training is able to enhance the muscles’ oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players’ muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy. Conclusions: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.

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“…Soccer-tennis players require specialized physical training embodied in dynamic muscular performance to perform technical skills, changes of direction, vertical and horizontal jumps in resistance and speed, as well as power and accuracy for hitting the ball [2]. Football-tennis at the competitive level requires athletes to activate the main muscle groups with a focus on the muscles of the lower limbs, an optimal functioning of the cardio-respiratory system [3][4][5][6], a proper adaptation of the vestibular apparatus [7][8][9][10], and metabolic processes [11,12]. The benefits of playing football-tennis are multiple, having an impact on physical capacity, mental capacity, communication and social integration capacity, team spirit formation, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Football-tennis is a dynamic activity, with variable effort intensity, from maximum to moderate depending on the phases of the game. Muscle training specific to strength development requires training adapted programs, typical of the game of football-tennis that must be based on in-depth knowledge of the skeletal muscle structure of the lower limbs (gluteal muscles, thigh muscles, tailor, femoral quadriceps, femoral biceps, thigh adductors), leg muscles (gastrocnemius, pronators and supinator of the leg, flexors and extensors), and plantar muscles (extensors of the toes and soles)), the type of voluntary muscle contractions, how to select and activate muscular fibres, and complex mechanisms specific to muscle contraction [11][12][13][14][15]. The balanced development of the muscles of the lower limbs of the football-tennis players represents an important condition for the optimization of the technical and physical performances [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Optimizing the Explosive Force of the Elite Level Football-Tennis Players through Plyometric and Specific Exercises

Gherghel

Bădău

et al. 2021

IJERPH

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The aim of the research was to implement an athletic program to improve the explosive force in order to optimize physical fitness at the level of elite football-tennis players and evaluate the progress made through specific tests using the Opto Jump. The research included 10 elite European and world-class players, on whom an experimental program was applied in order to improve the explosive force of the limbs in conditions of speed, endurance, and dynamic balance. Study tests: five vertical jumps on the spot, on the left/right leg; five back and forth jumps on the left/right leg; five left/right side jumps on the left/right leg; vertical jumps on both legs 60 s; BFS vertical jumps. For each test, the following parameters specific to the explosive force were statistically analyzed: contact time (s); flight time (s); jump height (cm), jump power (w/kg); RSI—Reactive Strength Index, defined as Height (m/s). In the study, the average value of the parameters specific to the jumps performed in each test was taken into account. During the study, the tests were performed and processed on the Opto Jump device and software. In all tests of the experiment monitored through Opto Jump, significant progress was made in the final test compared to the initial one, which demonstrates the efficiency of the physical training program implemented for the development of explosive force, with an impact on the sports performance of elite players. The most relevant results obtained for the left leg regarding the improvement of the explosive force of the lower limbs materialized in the jump height parameter was in the test of five vertical jumps on one leg on the spot, and for the right leg in the tests of: five back and forth jumps and five left/right side jumps. The most significant advances in the study were in the tests, in descending order of their weight: 60 s vertical jumps on both legs; five back-and-forth jumps and five left/right side jumps, five vertical jumps on one leg standing, and BFS vertical jumps.

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Long-Term Recreational Football Training and Health in Aging

Cited by 5 publications

References 102 publications

Regular football training down-regulates miR-1303 muscle expression in veterans

Regular football training down-regulates miR-1303 muscle expression in veterans

Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players

Optimizing the Explosive Force of the Elite Level Football-Tennis Players through Plyometric and Specific Exercises

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