Long term real life follow-up of patients with chronic hepatitis C virus and decompensated cirrhosis after direct acting antivirals – what is the clinical benefit of antiviral treatment?

Cheung, Michelle; Dj, Mutimer; Agarwal, Kosh; Brown, Abigail; Aldersley, M.; Foster, G.R.; Irving, William L.

doi:10.1016/s0168-8278(18)30436-7

Cited by 2 publications

(5 citation statements)

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“…Interleukin-28B belongs to type III IFNs, also called IFN-s, which was discovered in 2002 by two independent groups [5]. The human IL-28/29 cytokine family has three members: IL-28A, IL-28B, and IL-29.…”

Section: Discussionmentioning

confidence: 99%

“…The genes encoding IL28A, IL28B, and IL29 are aligned in sequence in a locus on chromosome 19q13. They are induced by viral infections (in intestinal epithelium) [5]. They have antiviral activity similar to all interferons, and additional ones with immunomodulatory effects.…”

Section: Discussionmentioning

confidence: 99%

“…Thomas et al [6] genotyped the rs12979860 SNP in HCV patients, from six cohorts, with well-characterized spontaneous clearance of HCV or viral perseverance and demonstrated that the genotype was strongly related to the clearance HCV. The level of IL-28B is a type of T-helper interleukins, a class II cytokine receptor ligand, a 200 amino acid long protein, a member of type III IFN-s, that indistinctly structurally relates to the members of IL-10 superfamily of cytokines, but parts also partial sequence similarity and efficient features with the type I IFN-s (α, β) [5]. Qahtani et al [7] found that there is a association between serum IL28B levels and the different SNP genotypes, a box-plot investigation was achieved for the diverse SNPs against average logarithmic values of IL28B levels.…”

Section: Discussionmentioning

confidence: 99%

“…Extended periods of HCV infection "persistent HCV infection" may lead to cirrhosis and even hepatocellular carcinoma (HCC) [2,3]. Up to date, the treatment of chronic HCV infection included a 6 to 1.5 year, course of interferon-alpha in accompanied with ribavirin [5,6]. This treatment eradicates HCV infection in only 40%-50% of patients infected with genotypes 1 or 4 and 75%-90% of those infected with genotypes 2 or 3 [1,2].…”

Section: Literature Reviewmentioning

confidence: 99%

“…The gene for interleukin-28B (IL28B) is found along with IL28Aand IL29 in a cytokine cluster at 19q13.13 and codes for IFNλ3. This gene is associated with the spontaneous clearance of HCV infection and with the response to standard therapy with IFN-α and ribavirin treatment in individuals with chronic HCV infection [5]. Few studies try to investigate the factors influence the clearance of the virions from patients with acute and chronic hepatitis for more than 10 years.…”

Section: Literature Reviewmentioning

confidence: 99%

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Role of Interleukin-28B in clearance of HCV in acute and chronic hepatitis patients in Kirkuk city

2018

KJAR

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A cross sectional study was conducted in Kirkuk city from June 2017 to March 2018. The number of hepatitis patient understudy were 62 hepatitis C (27 acute and 35 chronic) whose ages were between 20-75 years old. The purpose of this study was to evaluate the effect of IL28B in the clearance of HCV. These patients admitted to Hepatology and Gastroenterology centers of Kirkuk. The control group who were matched to the patients studied, included 30 individuals who admitted to blood bank for blood donation, for molecular test of HCV Real-time quantitative test and serum IL-28B ELISA. The study exhibited that 81.48 % of acute HCV patient who positive by ELISA were positive by PCR and 82.86 % of chronic HCV patients were positive by PCR with highly significant relation between them. Regarding the relation of IL-28B with HCV infection, the study presented that the highest mean of IL-28B was recorded among PCR-ve acute HCV patients (17.78 pg/ml) followed by PCR +ve acute HCV and the lowest means was found in the control group with highly significant differences among the groups. The study indicated that the highest mean of IL-28B was recorded among PCR-ve chronic HCV patients (17.78 pg/ml) followed by PCR +ve chronic HCV and the lowest means was found in the control group with highly significant relation. The study showed that the highest mean of ALT and AST were found in acute HCV patients (72.06 and 36.73 IU/ml) respectively followed by chronic HCV and the control group with highly significant relation among the groups.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

See 3 more Smart Citations

Role of Interleukin-28B in clearance of HCV in acute and chronic hepatitis patients in Kirkuk city

2018

KJAR

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Role of Interleukin-28B in clearance of HCV in acute and chronic hepatitis patients in Kirkuk city

Alazzawy

2018

KJAR

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A cross sectional study was conducted in Kirkuk city from June 2017 to March 2018. The number of hepatitis patient understudy were 62 hepatitis C (27 acute and 35 chronic) whose ages were between 20-75 years old. The purpose of this study was to evaluate the effect of IL28B in the clearance of HCV. These patients admitted to Hepatology and Gastroenterology centers of Kirkuk. The control group who were matched to the patients studied, included 30 individuals who admitted to blood bank for blood donation, for molecular test of HCV Real-time quantitative test and serum IL-28B ELISA. The study exhibited that 81.48 % of acute HCV patient who positive by ELISA were positive by PCR and 82.86 % of chronic HCV patients were positive by PCR with highly significant relation between them. Regarding the relation of IL-28B with HCV infection, the study presented that the highest mean of IL-28B was recorded among PCR –ve acute HCV patients (17.78 pg/ml) followed by PCR +ve acute HCV and the lowest means was found in the control group with highly significant differences among the groups. The study indicated that the highest mean of IL-28B was recorded among PCR –ve chronic HCV patients (17.78 pg/ml) followed by PCR +ve chronic HCV and the lowest means was found in the control group with highly significant relation. The study showed that the highest mean of ALT and AST were found in acute HCV patients (72.06 and 36.73 IU/ml) respectively followed by chronic HCV and the control group with highly significant relation among the groups.

show abstract

Long term real life follow-up of patients with chronic hepatitis C virus and decompensated cirrhosis after direct acting antivirals – what is the clinical benefit of antiviral treatment?

Cited by 2 publications

References 0 publications

Role of Interleukin-28B in clearance of HCV in acute and chronic hepatitis patients in Kirkuk city

Role of Interleukin-28B in clearance of HCV in acute and chronic hepatitis patients in Kirkuk city

Role of Interleukin-28B in clearance of HCV in acute and chronic hepatitis patients in Kirkuk city

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