Long-term quality of life among localised prostate cancer survivors: QALIPRO population-based study

Kerleau, Clarisse; Guizard, Anne‐Valérie; Daubisse‐Marliac, Laetitia; Heutte, Natacha; Mercier, Mariette; Grosclaude, Pascale; Joly, Florence; Woronoff, Anne‐Sophie; Trétarre, Brigitte; Delafosse, Patricia; Molinié, F.; Bara, Simona; Velten, Michel; Marrer, Émilie; Lapôtre-Ledoux, Bénédicte; Cowppli-Bony, Anne

doi:10.1016/j.ejca.2016.05.020

Cited by 30 publications

(35 citation statements)

References 35 publications

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“…Our results showed that the usual fatigue subscale was significantly higher only in cancer survivors and not in healthy subjects. Another report showed that cancer patients had similar levels of fatigue compared to healthy controls (Kerleau et al, 2016). The cancer survivors in this study did not have greater muscle weakness and lower muscle strength than did healthy subjects.…”

Section: Discussionsupporting

confidence: 54%

“…The overall muscle strength of cancer survivors is potentially closely linked to QOL.Many studies have demonstrated that cancer survivors experience fatigue more frequently than do healthy subjects(Sánchez- Jiménez et al, 2015). Another report showed that cancer patients had similar levels of fatigue compared to healthy controls(Kerleau et al, 2016). Our results showed that the usual fatigue subscale was significantly higher only in cancer survivors and not in healthy subjects.…”

supporting

confidence: 40%

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Cancer survivors exhibit a different relationship between muscle strength and health-related quality of life/fatigue compared to healthy subjects

Morishita

Tsubaki

Fu³

et al. 2018

Eur J Cancer Care

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We investigated the difference in relationship between muscle strength and quality of life (QOL)/fatigue in long-term cancer survivors and healthy subjects. Thirty-six cancer survivors and 29 healthy subjects were assessed for body composition and bone status at the calcaneus using the Osteo Sono Assessment Index. Muscle strength was evaluated via handgrip and knee extensor strength. Health-related QOL was assessed using the Medical Outcome Study 36-item Short-Form Health Survey. Fatigue was measured using the brief fatigue inventory. Cancer survivors exhibited lower QOL scores in the physical functioning, physical role function, bodily pain and general health domains (p < .05). Grip and knee extension muscle strength in cancer survivors was positively correlated with the physical function and bodily pain of QOL (p < .05). The usual fatigue subscale score was only significantly higher in cancer survivors than in healthy subjects (p < .05). However, there were no correlations between muscle strength and fatigue in cancer survivors. Our results showed that muscle strength was an important factor for improving QOL in cancer survivors. We believe that the findings of this study will be relevant in the context of planning rehabilitation for cancer survivors.

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Section: Discussionsupporting

confidence: 54%

supporting

confidence: 40%

Cancer survivors exhibit a different relationship between muscle strength and health-related quality of life/fatigue compared to healthy subjects

Morishita

Tsubaki

Fu³

et al. 2018

Eur J Cancer Care

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“…However, as also seen in other trials, sexual activity and sexual functioning were clearly more affected in PCa patients receiving long-term ADT [15,16], thus showing better sexual activity (p < 0.0001) and sexual functioning (p = 0.0067) in the CG. As expected for the PCa patients due to prior ADT and RP, respectively, the symptom scores "hormonal withdrawal" (p < 0.0001) and "incontinence assistance" (p = 0.0056) revealed pertinent current results.…”

Section: Discussionsupporting

confidence: 77%

Health-Related Quality of Life in 536 Long-Term Prostate Cancer Survivors after Treatment with Leuprorelin Acetate: A Combined Retrospective and Prospective Analysis

Hammerer¹,

Wirth

E³

2017

Urol Int

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Introduction: We investigated the health-related quality of life (HRQoL) of long-term prostate cancer patients who received leuprorelin acetate in microcapsules (LAM) for androgen-deprivation therapy (ADT). Methods: The observational study was carried out by 30 office-based German urologists in 536 prostate cancer (PCa) patients treated for ≥5 years with LAM and in 116 patients of an age-matched control group (CG). Data on HRQoL and health status was collected prospectively using validated questionnaires QLQ-C30, QLQ-PR25 and Karnofsky Index. Data on effectiveness (clinical response, prostate specific antigen [PSA], testosterone) and safety was collected retrospectively from patients' health records. We used descriptive statistics to analyze the data. Results: The mean treatment duration was 8.6 years (range 4.5-19.8 years). General health status (QLQ-C30) was comparable for both groups. Differences were observed regarding physical - and role functioning. ADT patients rated single items slightly worse than CG. Karnofsky-Index showed comparable high values (median of 90%). QLQ-PR25 revealed more PCa-related symptoms for ADT patients. Within 6 months, median PSA level declined >90% and median testosterone levels declined below castration level from 4.0 to 0.2 ng/mL. Clinical response (European Organisation for Research and Treatment of Cancer criteria) was observed in at least 90% of ADT patients. Conclusions: Long-term ADT with LAM is a well-accepted, tolerated, effective, and low-burden treatment option for patients with advanced, hormone-sensitive PCa.

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“…We previously published a longitudinal evaluation of QoL after intensity-modulated prostate radiotherapy in younger subjects (age range 50-80 years, median age 73) and found consistent results: quality of life at six months was generally similar to the baseline after temporary impairment at two months [3,4]. Other authors have also reported a moderate but transient impaired QoL after radiotherapy in younger patients [24]. Although a direct comparison has not been scientifically validated, we note that 25% of patients in this geriatric series experienced a 6-month QoL decrease versus 15.8% in our series with younger patients.…”

Section: Discussionmentioning

confidence: 57%

Can Comprehensive Geriatric Assessment Predict Tolerance of Radiotherapy for Localized Prostate Cancer in Men Aged 75 Years or Older?

Goineau

Campion

Commer

et al. 2020

Cancers

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Curative radiotherapy for prostate cancer is common in the elderly. However, concerns about potential toxicity have inhibited access to radiotherapy for this population, for whom preserving quality of life (QoL) is crucial. The primary endpoint was to identify predictors of impaired QoL in men aged 75 years or older treated with curative intent radiotherapy with or without androgen deprivation therapy (ADT) for localized prostate cancer. We prospectively performed comprehensive geriatric assessment (CGA) and administered QoL questionnaires to 208 elderly (>75 years) patients prior to, plus two and six months after, radiotherapy (NCT 02876237). The median age of the patients was 77 years (range 75–89). At the start of the study, comorbidities were highlighted in 65% of patients: 23% were depressed, 23% had cognitive impairment, and 16% had reduced independence. At six months, 9% of patients had a consistently decreased QoL (>20 points), and a further 16% had a more moderate reduction (10 to 20 points) in QoL. None of the parameters studied (tumor characteristic, treatment, or oncogeriatric parameters) were predictive of a reduced QoL following radiotherapy. Though co-existing geriatric impairment was common, QoL was maintained for 75% of patients six months after radiotherapy. CGA was poorly predictive of tolerance of prostatic radiotherapy. Geriatric assessments dedicated to quality of life following radiotherapy need to be developed.

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Long-term quality of life among localised prostate cancer survivors: QALIPRO population-based study

Cited by 30 publications

References 35 publications

Cancer survivors exhibit a different relationship between muscle strength and health-related quality of life/fatigue compared to healthy subjects

Cancer survivors exhibit a different relationship between muscle strength and health-related quality of life/fatigue compared to healthy subjects

Health-Related Quality of Life in 536 Long-Term Prostate Cancer Survivors after Treatment with Leuprorelin Acetate: A Combined Retrospective and Prospective Analysis

Can Comprehensive Geriatric Assessment Predict Tolerance of Radiotherapy for Localized Prostate Cancer in Men Aged 75 Years or Older?

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