Long-term quality of life after treatment for locally advanced oropharyngeal carcinoma: Surgery and postoperative radiotherapy versus concurrent chemoradiation

Boscolo‐Rizzo, Paolo; Stellin, Marco; Fuson, Roberto; Marchiori, Carlo; Gava, Alessandro; Mosto, Maria Cristina Da

doi:10.1016/j.oraloncology.2009.06.005

Cited by 68 publications

(78 citation statements)

References 20 publications

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“…For more accurate evaluation of swallowing function, detailed interviews with patients should be performed at several fixed times after treatment. On the other hand, Boscolo-Rizzo et al [10] evaluated the long-term quality of life in patients with advanced OPC and compared the results of patients treated with surgery and postoperative RT with those undergoing CCRT. They reported that surgical patients showed a statistically higher incidence of problems with swallowing and social eating.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, patients with advanced disease treated with surgical resection experience impairment of swallowing and speech function, leading to a decreased quality of life. Concurrent chemoradiotherapy (CCRT) has advantages over definitive surgery in terms of organ and function preservation, and over RT alone in terms of survival rate [9,10,11]. However, major concerns remain regarding the toxicity of CCRT, which sometimes requires long-term hospitalization and nutritional support.…”

Section: Introductionmentioning

confidence: 99%

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Matched-Pair Analysis in Patients with Advanced Oropharyngeal Cancer: Surgery versus Concurrent Chemoradiotherapy

Kano

Homma²,

Hayashi³

et al. 2013

Oncology

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Objective: The current study aimed to compare the therapeutic outcomes of surgery with those of chemoradiation for patients with advanced oropharyngeal cancer (OPC). Methods: The data for 523 patients with previously untreated OPC were obtained from 12 institutions belonging to the Head and Neck Cancer Study Group in the Japan Clinical Oncology Group from April 2005 to March 2007. In this study, we matched a group of patients who underwent surgery with a second group treated with chemoradiation according to age, gender, subsite, and T and N classification, and analyzed the overall survival, progression-free survival, local control and swallowing function. Results: The final matched-pair analysis included 186 patients. The 5-year overall survival, progression-free survival and local control rates were 69.8 and 71.4% (p = 0.762), 51.0 and 54.4% (p = 0.531), and 75.2 and 80.3% (p = 0.399), respectively, in patients treated with surgery and those treated with chemoradiation. Swallowing function in patients treated with chemoradiation was significantly better than that in patients treated with surgery (p = 0.015). Conclusion: Although this study was not randomized, this matched-pair analysis of patients treated with surgery or chemoradiation showed that chemoradiation is as effective as surgery in the treatment of OPC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Matched-Pair Analysis in Patients with Advanced Oropharyngeal Cancer: Surgery versus Concurrent Chemoradiotherapy

Kano

Homma²,

Hayashi³

et al. 2013

Oncology

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“…Boscolo-Rizzo et al (2009) used EORTC QLQ-C30 and H&N35 questionnaires in 57 patients with T3-4 oropharyngeal cancer, to compare 31 patients receiving concurrent chemoradiotherapy after surgery with 26 patients receiving radiotherapy. The group with chemoradiotherapy had better scores in fatigue, pain, swallowing problems, eating problems in social environment, inability to build social interaction, whereas disadvantages were found in terms of dental problems, the problem of opening the mouth, dry mouth and sticky saliva (Boscolo-Rizzo et al, 2009). Tschudi et al (2003) investigated the QOL after three different treatment modalities.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Quality of Life in Turkish Patients with Head and Neck Cancer

Akkaş¹,

Yücel²,

Kılıçkap³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: In this study, our aim was to investigate the effect of factors, such as radiotherapy, the dose of radiotherapy, the region of radiotherapy, the age of the patient, performance, co-morbidity, the stage of the disease and the therapy modalities on the quality of life of patients with head and neck cancer. Materials and Methods: Eighty-two patients who were treated by either chemoradiotherapy or radiotherapy, at the Cumhuriyet University Faculty of Medicine, Department of Radiation Oncology, between February 2007 and September 2010, for head and neck cancer were included. The quality of life European Organisation for Research and Treatment of Cancer, Questionnaire module to be used in Quality of Life assessments in Head and Neck Cancer (EORTC QLQ-H&N35) questionnaire was conducted in all patients before starting the radiotherapy, in the middle, at the end, at 1 month and at 6 months after the treatment. Results: According to the questionnaires at the end and at the 6 th month after the radiotherapy, it was found that the age of the patient, co-morbidity, ECOG performance state, localization, type of treatment, the stage of the disease, the dose and the region of radiotherapy affect some of the symptom scales for quality of life. Conclusions: Quality of life was affected negatively during and after the radiotherapy. However, in the 6 th month after the therapy, a significant improvement was observed in most symptoms.

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“…46 If partial response occurs, rescue surgery is added. 47 Intensity modulated radiation therapy (IMRT) is associated with less immediate and late toxicity. 48,49 However, its availability is limited in our country.…”

Section: Moderately Advanced or Resectable Tumorsmentioning

confidence: 99%

Oropharyngeal cancer: an emergent disease?

Granados-García

2016

Salud Publica Mex

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ResumenEl cáncer de orofarínge recientemente ha incrementado su incidencia, por lo que ha atraído la atención pública. Como en otras neoplasias malignas de las vías aerodigestivas superiores se atribuye a los efectos carcinogénicos del tabaco y alcohol, sin embargo evidencia reciente señala un incremento substancial atribuible a los efectos del virus del papiloma humano. Mucho se ha avanzado en relación a los conocimientos de los mecanismos moleculares y genéticos implicados en la génesis y progresión de estas neoplasias, lo que ha conducido al desarrollo de nuevas y prometedoras terapias, mas especificas y menos tóxicas, que han prolongado la vida y mejorado su calidad, pero no han logrado incrementar significativamente la proporción de pacientes curados. Si se desea abatir la mortalidad por estas neoplasias es necesario emprender medidas de salud publica dirigidas a su prevención y diagnóstico temprano.Palabras clave: cáncer de cabeza y cuello; cáncer de vías aerodigestivas; cáncer de orofaringe; tabaco; alcohol; virus del papiloma humano AbstractOropharyngeal cancer incidence has recently increased, thereby attracting public attention. Akin to other malignancies of the upper aerodigestive tract, it has been attributed to the carcinogenic effects of tobacco and alcohol use. However, recent evidence shows that a substantial increase in the disease is attributable to the effects of human papillomavirus (HPV). Marked progress has been made in relation to the knowledge of molecular and genetic mechanisms involved in the genesis and progression of these cancers. This has led to the development of new and promising therapies of a more specific and less toxic nature that have prolonged life and improved its quality. However, these therapies have failed to significantly increase the proportion of patients who are cured. To decrease the mortality associated with these neoplasms, it is necessary to adopt public health measures aimed at prevention and early diagnosis.Keywords: head and neck cancer; cancer of the aerodigestive tract; oropharyngeal cancer; tobacco; alcohol; human papillomavirus EpidemiologyIn Mexico, less than 500 oropharyngeal cancer cases occur among 148 000 malignancies diagnosed each year (annual age-adjusted incidence rate of 0.

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Long-term quality of life after treatment for locally advanced oropharyngeal carcinoma: Surgery and postoperative radiotherapy versus concurrent chemoradiation

Cited by 68 publications

References 20 publications

Matched-Pair Analysis in Patients with Advanced Oropharyngeal Cancer: Surgery versus Concurrent Chemoradiotherapy

Matched-Pair Analysis in Patients with Advanced Oropharyngeal Cancer: Surgery versus Concurrent Chemoradiotherapy

Evaluation of Quality of Life in Turkish Patients with Head and Neck Cancer

Oropharyngeal cancer: an emergent disease?

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